Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

Epithelial-to-mesenchymal transition (EMT) underlies cell plasticity and embryonic development and is frequently observed in advanced tumorigenesis. We demonstrated that midkine (MK), a retinoic acid-inducible heparin-binding mitogen, promotes EMT in immortalized HaCaT keratinocytes. We showed that...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2008-06, Vol.7 (11), p.1613-1622
Hauptverfasser:	Huang, Yiping, Hoque, Mohammad Obaidul, Wu, Feng, Trink, Barry, Sidransky, David, Ratovitski, Edward A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Calcium Cancer Cell Cell Differentiation - physiology Cycle Cytokines - genetics Cytokines - metabolism DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Epithelial Cells - cytology Epithelial Cells - drug effects Gene Expression Profiling Humans Immunoblotting Janus Kinase 2 - metabolism Keratinocytes - metabolism Landes Mesoderm - cytology Microscopy, Fluorescence Neoplasms - metabolism Organogenesis Proteins Receptor, Notch2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - physiology STAT3 Transcription Factor - metabolism Two-Hybrid System Techniques
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