Distortions in rest–activity rhythm in aging relate to white matter hyperintensities
Abstract Distortions in the rest–activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also pla...
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| Veröffentlicht in: | Neurobiology of aging 2008-08, Vol.29 (8), p.1265-1271 |
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| creator | Oosterman, J van Harten, B Vogels, R Gouw, A Weinstein, H Scheltens, P Scherder, E |
| description | Abstract Distortions in the rest–activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest–activity rhythm in aging. The present study focused on the rest–activity rhythm, as assessed with actigraphy, and WMH in nondemented aging. With regard to the rest–activity rhythm, the interdaily stability (IS), intradaily variability (IV) and the amplitude (AMP) of the rhythm were of interest. The white matter hyperintensities were examined separately for the periventricular (PVH) and deep white matter (DWMH) regions, while distinguishing between the various locations within these regions (e.g. occipital PVH). The results indicated that frontal DWMH related to both IS and AMP. A reduction in the most active 10-h period mediated the relationship between frontal DWMH and AMP. Possible underlying mechanisms of these associations are discussed. |
| doi_str_mv | 10.1016/j.neurobiolaging.2007.02.014 |
| format | Article |
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Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest–activity rhythm in aging. The present study focused on the rest–activity rhythm, as assessed with actigraphy, and WMH in nondemented aging. With regard to the rest–activity rhythm, the interdaily stability (IS), intradaily variability (IV) and the amplitude (AMP) of the rhythm were of interest. The white matter hyperintensities were examined separately for the periventricular (PVH) and deep white matter (DWMH) regions, while distinguishing between the various locations within these regions (e.g. occipital PVH). The results indicated that frontal DWMH related to both IS and AMP. A reduction in the most active 10-h period mediated the relationship between frontal DWMH and AMP. Possible underlying mechanisms of these associations are discussed.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2007.02.014</identifier><identifier>PMID: 17368870</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Actigraphy ; Adaptation, Physiological ; Aged ; Aging ; Aging - pathology ; Aging - physiology ; Female ; Humans ; Internal Medicine ; Male ; Motor Activity - physiology ; Nerve Fibers, Myelinated - ultrastructure ; Neurology ; Periodicity ; Rest - physiology ; Rest–activity rhythm ; Statistics as Topic ; White matter</subject><ispartof>Neurobiology of aging, 2008-08, Vol.29 (8), p.1265-1271</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-bcc0f857cbe755a2625e5059b833c3d37a8e219d95febe31eccd65365a1ced5b3</citedby><cites>FETCH-LOGICAL-c493t-bcc0f857cbe755a2625e5059b833c3d37a8e219d95febe31eccd65365a1ced5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2007.02.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17368870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oosterman, J</creatorcontrib><creatorcontrib>van Harten, B</creatorcontrib><creatorcontrib>Vogels, R</creatorcontrib><creatorcontrib>Gouw, A</creatorcontrib><creatorcontrib>Weinstein, H</creatorcontrib><creatorcontrib>Scheltens, P</creatorcontrib><creatorcontrib>Scherder, E</creatorcontrib><title>Distortions in rest–activity rhythm in aging relate to white matter hyperintensities</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Distortions in the rest–activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest–activity rhythm in aging. The present study focused on the rest–activity rhythm, as assessed with actigraphy, and WMH in nondemented aging. With regard to the rest–activity rhythm, the interdaily stability (IS), intradaily variability (IV) and the amplitude (AMP) of the rhythm were of interest. The white matter hyperintensities were examined separately for the periventricular (PVH) and deep white matter (DWMH) regions, while distinguishing between the various locations within these regions (e.g. occipital PVH). The results indicated that frontal DWMH related to both IS and AMP. A reduction in the most active 10-h period mediated the relationship between frontal DWMH and AMP. Possible underlying mechanisms of these associations are discussed.</description><subject>Actigraphy</subject><subject>Adaptation, Physiological</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>Neurology</subject><subject>Periodicity</subject><subject>Rest - physiology</subject><subject>Rest–activity rhythm</subject><subject>Statistics as Topic</subject><subject>White matter</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EotPCK6AsELsEO47tREJIqNCCVIkFP1vLce507pDYg-0UZcc78IY8CQ4zEoIVK1u659yf7xDylNGKUSaf7ysHc_A9-tHcorutakpVReuKsuYe2TAh2pI1nbpPNpR1qmxES8_IeYx7moWNkg_JGVNctq2iG_L5NcbkQ0LvYoGuCBDTz-8_jE14h2kpwm5Ju2mt_B6W66NJUCRffNth_kwmJQjFbjlAQJfARUwI8RF5sDVjhMen94J8unrz8fJtefP--t3lq5vSNh1PZW8t3bZC2R6UEKaWtQBBRde3nFs-cGVaqFk3dGILPXAG1g5ScCkMszCInl-QZ8e-h-C_znl3PWG0MI7GgZ-jll3NhWQyC18chTb4GANs9SHgZMKiGdUrV73Xf3PVK1dNa525ZvuT05y5n2D4Yz6BzIKrowDytXcIQUeL4PKWGMAmPXj830kv_2lkR3RozfgFFoh7PweXiWqmYzboD2vGa8RU5XhFw_gvOjSqqQ</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Oosterman, J</creator><creator>van Harten, B</creator><creator>Vogels, R</creator><creator>Gouw, A</creator><creator>Weinstein, H</creator><creator>Scheltens, P</creator><creator>Scherder, E</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Distortions in rest–activity rhythm in aging relate to white matter hyperintensities</title><author>Oosterman, J ; van Harten, B ; Vogels, R ; Gouw, A ; Weinstein, H ; Scheltens, P ; Scherder, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-bcc0f857cbe755a2625e5059b833c3d37a8e219d95febe31eccd65365a1ced5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Actigraphy</topic><topic>Adaptation, Physiological</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>Neurology</topic><topic>Periodicity</topic><topic>Rest - physiology</topic><topic>Rest–activity rhythm</topic><topic>Statistics as Topic</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oosterman, J</creatorcontrib><creatorcontrib>van Harten, B</creatorcontrib><creatorcontrib>Vogels, R</creatorcontrib><creatorcontrib>Gouw, A</creatorcontrib><creatorcontrib>Weinstein, H</creatorcontrib><creatorcontrib>Scheltens, P</creatorcontrib><creatorcontrib>Scherder, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oosterman, J</au><au>van Harten, B</au><au>Vogels, R</au><au>Gouw, A</au><au>Weinstein, H</au><au>Scheltens, P</au><au>Scherder, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distortions in rest–activity rhythm in aging relate to white matter hyperintensities</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>29</volume><issue>8</issue><spage>1265</spage><epage>1271</epage><pages>1265-1271</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract Distortions in the rest–activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest–activity rhythm in aging. The present study focused on the rest–activity rhythm, as assessed with actigraphy, and WMH in nondemented aging. With regard to the rest–activity rhythm, the interdaily stability (IS), intradaily variability (IV) and the amplitude (AMP) of the rhythm were of interest. The white matter hyperintensities were examined separately for the periventricular (PVH) and deep white matter (DWMH) regions, while distinguishing between the various locations within these regions (e.g. occipital PVH). The results indicated that frontal DWMH related to both IS and AMP. A reduction in the most active 10-h period mediated the relationship between frontal DWMH and AMP. Possible underlying mechanisms of these associations are discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17368870</pmid><doi>10.1016/j.neurobiolaging.2007.02.014</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Actigraphy Adaptation, Physiological Aged Aging Aging - pathology Aging - physiology Female Humans Internal Medicine Male Motor Activity - physiology Nerve Fibers, Myelinated - ultrastructure Neurology Periodicity Rest - physiology Rest–activity rhythm Statistics as Topic White matter |
| title | Distortions in rest–activity rhythm in aging relate to white matter hyperintensities |
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