Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis

Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to identify targets of palmitate in β-cell death. The most significantly altered protein in both human islets and MIN6 β-cells treated with palm...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-06, Vol.105 (24), p.8452-8457
Hauptverfasser:	Jeffrey, Kristin D, Alejandro, Emilyn U, Luciani, Dan S, Kalynyak, Tatyana B, Hu, Xiaoke, Li, Hong, Lin, Yalin, Townsend, R. Reid, Polonsky, Kenneth S, Johnson, James D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Biological Sciences Carboxypeptidase H - genetics Carboxypeptidase H - metabolism Cell Survival Cells, Cultured Diabetes Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Endoplasmic Reticulum - enzymology Fatty acids Gels Golgi Apparatus - enzymology Humans Hyperglycemia - enzymology Hyperglycemia - genetics Hyperinsulinism - enzymology Hyperinsulinism - genetics Insulin Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - enzymology Insulin-Secreting Cells - ultrastructure Islets of Langerhans Mice Mice, Mutant Strains Nonesterified fatty acids Obesity Palmitates Palmitates - metabolism Palmitates - pharmacology Proteome Type 2 diabetes mellitus
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