Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

A novel series of donepezil−tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced Aβ aggregation. The...

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Veröffentlicht in:	Journal of medicinal chemistry 2008-06, Vol.51 (12), p.3588-3598
Hauptverfasser:	Camps, Pelayo, Formosa, Xavier, Galdeano, Carles, Gómez, Tània, Muñoz-Torrero, Diego, Scarpellini, Michele, Viayna, Elisabet, Badia, Albert, Clos, M. Victòria, Camins, Antoni, Pallàs, Mercè, Bartolini, Manuela, Mancini, Francesca, Andrisano, Vincenza, Estelrich, Joan, Lizondo, Mònica, Bidon-Chanal, Axel, Luque, F. Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Amyloid beta-Peptides - chemistry Animals Binding Sites Biological and medical sciences Butyrylcholinesterase - chemistry Cattle Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Humans Indans - chemical synthesis Indans - chemistry Medical sciences Models, Molecular Neuropharmacology Pharmacology. Drug treatments Piperidines - chemical synthesis Piperidines - chemistry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Structure-Activity Relationship Tacrine - analogs & derivatives Tacrine - chemical synthesis Tacrine - chemistry
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