Evidence for Autocrine Actions of Neuromedin B and Gastrin-releasing Peptide in Non-small Cell Lung Cancer

Gastrin-releasing peptide (GRP), a member of the bombesin family of peptides, has been shown to have mitogenic activity in small cell lung carcinoma (SCLC), and to be produced by SCLC in an autocrine fashion. In this report, we demonstrate that both GRP and another member of the bombesin family of p...

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 1999-01, Vol.12 (5), p.291-302
Hauptverfasser:	Siegfried, J.M., Krishnamachary, N., Gaither Davis, A., Gubish, C., Hunt, J.D., Shriver, S.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Blocking - pharmacology Antibodies, Monoclonal - pharmacology Autocrine Communication - drug effects Bombesin-like peptide, Neuromedin B, Gastrin-releasing peptide, Lung cancer, Non-small cell lung cancer, Autocrine growth factor Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Cell Division - drug effects Culture Media, Conditioned Female Gastrin-Releasing Peptide - pharmacology Humans Immunoblotting Lung Neoplasms - drug therapy Lung Neoplasms - pathology Mice Mice, Nude Mitogens - pharmacology Neurokinin B - analogs & derivatives Neurokinin B - pharmacology Receptors, Bombesin - biosynthesis Receptors, Bombesin - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis
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