B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones
Th 17 cells represent a novel subset of CD4+ T cells that have a protective effect against extracellular microbes, while they are also responsible for autoimmune disorders in mice. However, the protein expression profile of Th17 cells remains to be clarified. In this study, we report an effective me...
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| Veröffentlicht in: | The Journal of immunology (1950) 2008-07, Vol.181 (1), p.186-189 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 181 |
| creator | Takagi, Rie Higashi, Takehiro Hashimoto, Kumiko Nakano, Kazuhisa Mizuno, Yosuke Okazaki, Yasushi Matsushita, Sho |
| description | Th 17 cells represent a novel subset of CD4+ T cells that have a protective effect against extracellular microbes, while they are also responsible for autoimmune disorders in mice. However, the protein expression profile of Th17 cells remains to be clarified. In this study, we report an effective method to establish human allo-reactive Th17 cell clones and demonstrate that human Th17, but not Th1 or Th2, cells express B cell chemoattractant CXCL13, by using DNA chips, RT-PCR, and ELISA. Such a pattern was also the case in Candida albicans-specific Th17 clones and synovial fluid specimens obtained from patients with rheumatoid arthritis. The biological implication of this finding is discussed. |
| doi_str_mv | 10.4049/jimmunol.181.1.186 |
| format | Article |
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The biological implication of this finding is discussed.</description><subject>Allosteric Regulation - immunology</subject><subject>Candida</subject><subject>Cells, Cultured</subject><subject>Chemokine CXCL13 - genetics</subject><subject>Chemokine CXCL13 - immunology</subject><subject>Chemokine CXCL13 - metabolism</subject><subject>Coculture Techniques</subject><subject>Humans</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>RNA, Messenger - genetics</subject><subject>Synovial Fluid - immunology</subject><subject>Synovial Fluid - metabolism</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Transcription, Genetic - genetics</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUQC0EoqXwAwzIE1vK9SOOM0JUaKVKIFEkNst1HJoqj2InKv17DC3qiO7g5fjY9yB0TWDMgad367Ku-6atxkSScRgpTtCQxDFEQoA4RUMASiOSiGSALrxfA4AAys_RgMhYCCbZEL0-4MxWFc5Wtm511zltOt10OHvP5oThmccvzhbW2aYrdVXt8ORr46z3NsfLHZ72tW7wYkWSg6VqG-sv0VmhK2-vDucIvT1OFtk0mj8_zbL7eWR4wrooL4ACLcAIngpDOFDJWJGCYWyZ6piAKUAwbrXJk1yyXCR5ABNm0lwWAJyN0O3eu3HtZ299p-rSm_AP3di290qklJFEin9BCjKOuUwDSPegca33YXG1cWWt3U4RUD_N1V9zFZqrML_2m4O9X9Y2P145RD4-vyo_VtvSWeXr0DLgRG2326PpG9rFik4</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Takagi, Rie</creator><creator>Higashi, Takehiro</creator><creator>Hashimoto, Kumiko</creator><creator>Nakano, Kazuhisa</creator><creator>Mizuno, Yosuke</creator><creator>Okazaki, Yasushi</creator><creator>Matsushita, Sho</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones</title><author>Takagi, Rie ; Higashi, Takehiro ; Hashimoto, Kumiko ; Nakano, Kazuhisa ; Mizuno, Yosuke ; Okazaki, Yasushi ; Matsushita, Sho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-df0202f0c6496c1402833f90c33b9a510cf0634eacd7d83d67d49673c9d8f0043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Allosteric Regulation - immunology</topic><topic>Candida</topic><topic>Cells, Cultured</topic><topic>Chemokine CXCL13 - genetics</topic><topic>Chemokine CXCL13 - immunology</topic><topic>Chemokine CXCL13 - metabolism</topic><topic>Coculture Techniques</topic><topic>Humans</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>RNA, Messenger - genetics</topic><topic>Synovial Fluid - immunology</topic><topic>Synovial Fluid - metabolism</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>Transcription, Genetic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takagi, Rie</creatorcontrib><creatorcontrib>Higashi, Takehiro</creatorcontrib><creatorcontrib>Hashimoto, Kumiko</creatorcontrib><creatorcontrib>Nakano, Kazuhisa</creatorcontrib><creatorcontrib>Mizuno, Yosuke</creatorcontrib><creatorcontrib>Okazaki, Yasushi</creatorcontrib><creatorcontrib>Matsushita, Sho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takagi, Rie</au><au>Higashi, Takehiro</au><au>Hashimoto, Kumiko</au><au>Nakano, Kazuhisa</au><au>Mizuno, Yosuke</au><au>Okazaki, Yasushi</au><au>Matsushita, Sho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>181</volume><issue>1</issue><spage>186</spage><epage>189</epage><pages>186-189</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Th 17 cells represent a novel subset of CD4+ T cells that have a protective effect against extracellular microbes, while they are also responsible for autoimmune disorders in mice. 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| subjects | Allosteric Regulation - immunology Candida Cells, Cultured Chemokine CXCL13 - genetics Chemokine CXCL13 - immunology Chemokine CXCL13 - metabolism Coculture Techniques Humans Oligonucleotide Array Sequence Analysis RNA, Messenger - genetics Synovial Fluid - immunology Synovial Fluid - metabolism T-Lymphocytes, Helper-Inducer - immunology Transcription, Genetic - genetics |
| title | B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones |
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