Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients
Several studies have suggested that there is a substantial genetic contribution to suicidal behavior. Genes encoding proteins involved in serotonergic transmission are major candidates in association studies of suicidal behavior. In this study, we aimed to investigate the 5-HT2A receptor (5HTR2A) an...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2008-07, Vol.32 (5), p.1293-1297 |
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| creator | Yoon, Ho-Kyoung Kim, Yong-Ku |
| description | Several studies have suggested that there is a substantial genetic contribution to suicidal behavior. Genes encoding proteins involved in serotonergic transmission are major candidates in association studies of suicidal behavior. In this study, we aimed to investigate the 5-HT2A receptor (5HTR2A) and tryptophan hydroxylase (TPH) genes for association with suicidal behavior in depressive patients.
Patients with major depression who had recently attempted suicide (
n
=
191) and control subjects (
n
=
193) were genotyped for 5HTR2A 102T/C, and TPH 218A/C. The lethality of the suicide attempt was measured using the Risk-Rescue Rating (RRR) and Lethality Suicide Attempt Rating Scale (LSARS). The severity of depression was measured using the Hamilton Depression Rating Scale (HDRS).
There were no significant differences in the genotype distributions or allelic frequencies in the two serotonergic polymorphisms between suicide attempters and normal controls. None of the two serotonergic polymorphisms was correlated with lethality.
We concluded that these polymorphisms may not be associated with susceptibility to suicidal behavior in our Korean population. Our results were in line with most previous studies. More work is needed to replicate these findings. Our future studies aim at identifying other genetic associations. |
| doi_str_mv | 10.1016/j.pnpbp.2008.04.004 |
| format | Article |
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Patients with major depression who had recently attempted suicide (
n
=
191) and control subjects (
n
=
193) were genotyped for 5HTR2A 102T/C, and TPH 218A/C. The lethality of the suicide attempt was measured using the Risk-Rescue Rating (RRR) and Lethality Suicide Attempt Rating Scale (LSARS). The severity of depression was measured using the Hamilton Depression Rating Scale (HDRS).
There were no significant differences in the genotype distributions or allelic frequencies in the two serotonergic polymorphisms between suicide attempters and normal controls. None of the two serotonergic polymorphisms was correlated with lethality.
We concluded that these polymorphisms may not be associated with susceptibility to suicidal behavior in our Korean population. Our results were in line with most previous studies. More work is needed to replicate these findings. Our future studies aim at identifying other genetic associations.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2008.04.004</identifier><identifier>PMID: 18502553</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Depression ; Depression - genetics ; Depression - psychology ; DNA Mutational Analysis ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Korean ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropharmacology ; Pharmacology. Drug treatments ; Polymorphism ; Polymorphism, Genetic - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptor, Serotonin, 5-HT2A - genetics ; Retrospective Studies ; Self-Injurious Behavior - genetics ; Serotonin 2A receptor ; Suicide ; Tryptophan hydroxylase ; Tryptophan Hydroxylase - genetics</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2008-07, Vol.32 (5), p.1293-1297</ispartof><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-d5cfd185e16a1421038911676a04d5fd8afcbdd2fb0c7cd2fcc98a2532f22fe63</citedby><cites>FETCH-LOGICAL-c418t-d5cfd185e16a1421038911676a04d5fd8afcbdd2fb0c7cd2fcc98a2532f22fe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2008.04.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20522235$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18502553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Ho-Kyoung</creatorcontrib><creatorcontrib>Kim, Yong-Ku</creatorcontrib><title>Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Several studies have suggested that there is a substantial genetic contribution to suicidal behavior. Genes encoding proteins involved in serotonergic transmission are major candidates in association studies of suicidal behavior. In this study, we aimed to investigate the 5-HT2A receptor (5HTR2A) and tryptophan hydroxylase (TPH) genes for association with suicidal behavior in depressive patients.
Patients with major depression who had recently attempted suicide (
n
=
191) and control subjects (
n
=
193) were genotyped for 5HTR2A 102T/C, and TPH 218A/C. The lethality of the suicide attempt was measured using the Risk-Rescue Rating (RRR) and Lethality Suicide Attempt Rating Scale (LSARS). The severity of depression was measured using the Hamilton Depression Rating Scale (HDRS).
There were no significant differences in the genotype distributions or allelic frequencies in the two serotonergic polymorphisms between suicide attempters and normal controls. None of the two serotonergic polymorphisms was correlated with lethality.
We concluded that these polymorphisms may not be associated with susceptibility to suicidal behavior in our Korean population. Our results were in line with most previous studies. More work is needed to replicate these findings. Our future studies aim at identifying other genetic associations.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depression - genetics</subject><subject>Depression - psychology</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Korean</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptor, Serotonin, 5-HT2A - genetics</subject><subject>Retrospective Studies</subject><subject>Self-Injurious Behavior - genetics</subject><subject>Serotonin 2A receptor</subject><subject>Suicide</subject><subject>Tryptophan hydroxylase</subject><subject>Tryptophan Hydroxylase - genetics</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvLL0BCudBbwtiJHe-BQ1VRilSJCz1bjj2hXiV28GQX9d_jsiu40dPM4XtPM-8x9o5Dw4Grj7tmicuwNAJAN9A1AN0LtuG613UnuHrJNiDKLnWnztgboh0A8Bba1-yMawlCynbD8IoouWDXkGI14PoLMVaEOa0phlhnnOyKvvqBEaslTY9zystDoJkqG31F--CCt1NRPthDSLkKsfK4ZCQKh6IovhhXumCvRjsRvj3Nc3Z_8_n79W199-3L1-uru9p1XK-1l2705TbkyvLyA7R6y7nqlYXOy9FrO7rBezEO4HpXpnNbbYVsxSjEiKo9Z5dH3yWnn3uk1cyBHE6TjZj2ZNRWtFz23bOgAKF60FDA9gi6nIgyjmbJYbb50XAwTzWYnflTg3mqwUBnSg1F9f5kvx9m9P80p9wL8OEEWHJ2GrONLtBfToAUQrSycJ-OHJbUDgGzIVcSdehDRrcan8J_D_kN4pyphw</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Yoon, Ho-Kyoung</creator><creator>Kim, Yong-Ku</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients</title><author>Yoon, Ho-Kyoung ; Kim, Yong-Ku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-d5cfd185e16a1421038911676a04d5fd8afcbdd2fb0c7cd2fcc98a2532f22fe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depression - genetics</topic><topic>Depression - psychology</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Korean</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Receptor, Serotonin, 5-HT2A - genetics</topic><topic>Retrospective Studies</topic><topic>Self-Injurious Behavior - genetics</topic><topic>Serotonin 2A receptor</topic><topic>Suicide</topic><topic>Tryptophan hydroxylase</topic><topic>Tryptophan Hydroxylase - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Ho-Kyoung</creatorcontrib><creatorcontrib>Kim, Yong-Ku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Ho-Kyoung</au><au>Kim, Yong-Ku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>32</volume><issue>5</issue><spage>1293</spage><epage>1297</epage><pages>1293-1297</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Several studies have suggested that there is a substantial genetic contribution to suicidal behavior. Genes encoding proteins involved in serotonergic transmission are major candidates in association studies of suicidal behavior. In this study, we aimed to investigate the 5-HT2A receptor (5HTR2A) and tryptophan hydroxylase (TPH) genes for association with suicidal behavior in depressive patients.
Patients with major depression who had recently attempted suicide (
n
=
191) and control subjects (
n
=
193) were genotyped for 5HTR2A 102T/C, and TPH 218A/C. The lethality of the suicide attempt was measured using the Risk-Rescue Rating (RRR) and Lethality Suicide Attempt Rating Scale (LSARS). The severity of depression was measured using the Hamilton Depression Rating Scale (HDRS).
There were no significant differences in the genotype distributions or allelic frequencies in the two serotonergic polymorphisms between suicide attempters and normal controls. None of the two serotonergic polymorphisms was correlated with lethality.
We concluded that these polymorphisms may not be associated with susceptibility to suicidal behavior in our Korean population. Our results were in line with most previous studies. More work is needed to replicate these findings. Our future studies aim at identifying other genetic associations.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18502553</pmid><doi>10.1016/j.pnpbp.2008.04.004</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Depression Depression - genetics Depression - psychology DNA Mutational Analysis Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Korean Male Medical sciences Middle Aged Mood disorders Neuropharmacology Pharmacology. Drug treatments Polymorphism Polymorphism, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor, Serotonin, 5-HT2A - genetics Retrospective Studies Self-Injurious Behavior - genetics Serotonin 2A receptor Suicide Tryptophan hydroxylase Tryptophan Hydroxylase - genetics |
| title | Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients |
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