Lentiviral vector-mediated siRNA knockdown of SR-PSOX inhibits foam cell formation in vitro

Aim： To investigate the expression of scavenger receptor that binds phosphatidylserine and oxidized lipoprotein （SR-PSOX）/CXC chemokine ligand 16 （CXCL16） in the human monocyte-derived cell line THP-1, and the effect of lentiviral vectors for the stable delivery of SR-PSOX/CXCL 16 short hairpin RNA...

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Veröffentlicht in:	Acta pharmacologica Sinica 2008-07, Vol.29 (7), p.847-852
Hauptverfasser:	Zhang, Li, Liu, Hou-jia, Li, Tie-jun, Yang, Yang, Guo, Xian-ling, Wu, Meng-chao, Rui, Yao-cheng, Wei, Li-xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Line Cell Survival - drug effects Chemokine CXCL16 Chemokines, CXC - genetics Chemokines, CXC - physiology Cholesterol, LDL - metabolism CXCL16 Dose-Response Relationship, Drug Foam Cells - drug effects Genetic Vectors Humans Immunology Internal Medicine Lentivirus - genetics Medical Microbiology Monocytes - metabolism original-article Pharmacology/Toxicology Receptors, Scavenger - genetics Receptors, Scavenger - physiology Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - genetics SR-PSOX Transduction, Genetic Vaccine 低密度脂蛋白动脉粥样硬化
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