Early Drug Distribution: A Generally Neglected Aspect of Pharmacokinetics of Particular Relevance to Intravenously Administered Anesthetic Agents
There is considerable variability in response to intravenously administered anesthetic drugs (e.g., hypnotics, benzodiazepines, and narcotics) that have a rapid onset of effect (such as hypnosis, anxiolysis, and analgesia) and a low margin of safety (because of cardiovascular or respiratory depressi...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2008-07, Vol.84 (1), p.18-22 |
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| container_title | Clinical pharmacology and therapeutics |
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| creator | Henthorn, TK Krejcie, TC Avram, MJ |
| description | There is considerable variability in response to intravenously administered anesthetic drugs (e.g., hypnotics, benzodiazepines, and narcotics) that have a rapid onset of effect (such as hypnosis, anxiolysis, and analgesia) and a low margin of safety (because of cardiovascular or respiratory depression, etc.). Although the onset of effect for these drugs occurs seconds to minutes after injection, traditional pharmacokinetic models are based on blood samples that are first obtained after drug effects have peaked. As a result, many studies have failed to provide a pharmacokinetic rationale for dosage adjustments of these drugs.
Clinical Pharmacology & Therapeutics (2008); 84, 1, 18–22 doi:10.1038/clpt.2008.107 |
| doi_str_mv | 10.1038/clpt.2008.107 |
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Clinical Pharmacology & Therapeutics (2008); 84, 1, 18–22 doi:10.1038/clpt.2008.107</description><subject>Anesthesia, Intravenous - methods</subject><subject>Anesthetics, Intravenous - blood</subject><subject>Anesthetics, Intravenous - pharmacokinetics</subject><subject>Dose-Response Relationship, Drug</subject><subject>Humans</subject><subject>Time Factors</subject><issn>0009-9236</issn><issn>1532-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-P1CAYh4nRuOPq0avBi7euQKf88dbMrusmE52Y8dxQ-jJbpXQEumY-ht9Yake9eYIfPO_DG16EXlJyRUkp3xp3TFeMEJmjeIRWtCpZwauyeoxWhBBVKFbyC_Qsxq85rpWUT9EFlRUvCVcr9PNGB3fC12E64Os-ptC3U-pH_w7X-BY8BO3y9Uc4ODAJOlzHY97g0eLdvQ6DNuO33kPqTfx9pkPeTk4H_BkcPGhvAKcR3_kU9AP4cYrZVndD7_NbEGahh5juZwOuD-BTfI6eWO0ivDivl-jL-5v95kOx_XR7t6m3hSm5EIVmXPCOUdXyrpKVpGTNmSylFa1tFeEdaVtrjaWVtIYLqw0FQrRk3VqspWrLS_Rm8R7D-H3KTTRDHw04pz3kPhuuGFOCVRksFtCEMcYAtjmGftDh1FDSzDNo5hk08wxyFJl_dRZP7QDdP_r86RlQC_Cjd3D6v63Z7Pab7W4_50X-eqn1Ok0B_hbPRX-YX6Gfoog</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Henthorn, TK</creator><creator>Krejcie, TC</creator><creator>Avram, MJ</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Early Drug Distribution: A Generally Neglected Aspect of Pharmacokinetics of Particular Relevance to Intravenously Administered Anesthetic Agents</title><author>Henthorn, TK ; Krejcie, TC ; Avram, MJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3677-a2676d219b6d585810462838f7bfb906d0bbffcf158fc67fac1e00a82d47489b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anesthesia, Intravenous - methods</topic><topic>Anesthetics, Intravenous - blood</topic><topic>Anesthetics, Intravenous - pharmacokinetics</topic><topic>Dose-Response Relationship, Drug</topic><topic>Humans</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henthorn, TK</creatorcontrib><creatorcontrib>Krejcie, TC</creatorcontrib><creatorcontrib>Avram, MJ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henthorn, TK</au><au>Krejcie, TC</au><au>Avram, MJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Drug Distribution: A Generally Neglected Aspect of Pharmacokinetics of Particular Relevance to Intravenously Administered Anesthetic Agents</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clin Pharmacol Ther</addtitle><date>2008-07</date><risdate>2008</risdate><volume>84</volume><issue>1</issue><spage>18</spage><epage>22</epage><pages>18-22</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><abstract>There is considerable variability in response to intravenously administered anesthetic drugs (e.g., hypnotics, benzodiazepines, and narcotics) that have a rapid onset of effect (such as hypnosis, anxiolysis, and analgesia) and a low margin of safety (because of cardiovascular or respiratory depression, etc.). Although the onset of effect for these drugs occurs seconds to minutes after injection, traditional pharmacokinetic models are based on blood samples that are first obtained after drug effects have peaked. As a result, many studies have failed to provide a pharmacokinetic rationale for dosage adjustments of these drugs.
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| ispartof | Clinical pharmacology and therapeutics, 2008-07, Vol.84 (1), p.18-22 |
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| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Anesthesia, Intravenous - methods Anesthetics, Intravenous - blood Anesthetics, Intravenous - pharmacokinetics Dose-Response Relationship, Drug Humans Time Factors |
| title | Early Drug Distribution: A Generally Neglected Aspect of Pharmacokinetics of Particular Relevance to Intravenously Administered Anesthetic Agents |
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