Mechanisms of Protection Afforded by Cyclooxygenase Inhibitors to Endothelial Function Against Ischemic Injury in Rat Isolated Hearts

The aim of this study was to assess whether cyclooxygenase (COX) inhibitors protect the endothelial function against the deleterious effect of ischemia and reperfusion. Isolated rat hearts perfused under constant-flow conditions were exposed to 30 min of partial ischemia (flow, 1 ml/min) followed by...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1999-11, Vol.34 (5), p.755-763
Hauptverfasser:	Bouchard, Jean-François, Lamontagne, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Biological and medical sciences Cardiotonic Agents - therapeutic use Cardiovascular system Coronary Circulation - drug effects Coronary Vessels - drug effects Coronary Vessels - physiology Cyclooxygenase Inhibitors - therapeutic use Diclofenac - therapeutic use Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Imidazoles - pharmacology In Vitro Techniques Indomethacin - pharmacology Male Medical sciences Miscellaneous Myocardial Ischemia - prevention & control Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Pharmacology. Drug treatments Random Allocation Rats Rats, Sprague-Dawley Vascular Resistance - drug effects
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