IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk

A recent genome-wide scan of nonsynonymous SNPs and ulterior validation in case-control and family analyses evidenced a susceptibility locus for type 1 diabetes (T1D) on chromosome 2q24.3. We aimed at testing the effect of this locus in other autoimmune diseases with complex genetic background, such...

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Veröffentlicht in:	European journal of human genetics : EJHG 2008-07, Vol.16 (7), p.861-864
Hauptverfasser:	Martínez, Alfonso, Santiago, José Luis, Cénit, M Carmen, de las Heras, Virginia, de la Calle, Hermenegildo, Fernández-Arquero, Miguel, Arroyo, Rafael, de la Concha, Emilio G, Urcelay, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedicine Calcium-Binding Proteins - genetics Chromosome 2 Chromosomes, Human, Pair 2 - genetics Cytogenetics DEAD-box RNA Helicases - genetics Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Disease DNA helicase Ether-A-Go-Go Potassium Channels - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Frequency General aspects. Genetic counseling Genes Genetic Predisposition to Disease Genetics Genetics of eukaryotes. Biological and molecular evolution Genomes Human Genetics Humans Immunology Infections Interferon Interferon-Induced Helicase, IFIH1 Linkage disequilibrium Localization Male Medical genetics Medical sciences Molecular and cellular biology Multiple sclerosis Multiple Sclerosis - genetics Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Pathogenesis Polymorphism, Single Nucleotide - genetics Replication Sclerosis Single-nucleotide polymorphism Susceptibility Viral infections Womens health
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