A Fluorescent Core−Shell Dendritic Macromolecule Specifically Stains The Extracellular Matrix
The extracellular cell matrix (ECM) surrounds cells and plays important roles in many aspects of cellular fate, including cell migration, stem cell differentiation, and cancer progression. So far, there is no fluorescent dye to directly visualize the ECM network. Here we present a positively charged...
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| Veröffentlicht in: | Journal of the American Chemical Society 2008-06, Vol.130 (25), p.7806-7807 |
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| container_title | Journal of the American Chemical Society |
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| creator | Yin, Meizhen Shen, Jie Pflugfelder, Gert O Müllen, Klaus |
| description | The extracellular cell matrix (ECM) surrounds cells and plays important roles in many aspects of cellular fate, including cell migration, stem cell differentiation, and cancer progression. So far, there is no fluorescent dye to directly visualize the ECM network. Here we present a positively charged fluorescent core−shell dendritic macromolecule containing multiple −NH2 groups which specifically binds to highly negatively charged ECM components. Due to its advantageous optical properties and biological specificity, the dye is useful as a routine tool to label the ECM in life science research. |
| doi_str_mv | 10.1021/ja8022362 |
| format | Article |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Coloring Agents - chemistry Dendrimers - chemistry Extracellular Matrix - chemistry Fluorescent Dyes - chemistry Histocytochemistry - methods Staining and Labeling - methods |
| title | A Fluorescent Core−Shell Dendritic Macromolecule Specifically Stains The Extracellular Matrix |
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