Glucokinase Overexpression Restores Glucose Utilization and Storage in Cultured Hepatocytes from Male Zucker Diabetic Fatty Rats

Zucker diabetic fatty rats develop type 2 diabetes concomitantly with peripheral insulin resistance. Hepatocytes from these rats and their control lean counterparts have been cultured, and a number of key parameters of glucose metabolism have been determined. Glucokinase activity was 4.5-fold lower...

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Veröffentlicht in:	The Journal of biological chemistry 1999-11, Vol.274 (45), p.31833-31838
Hauptverfasser:	Seoane, Joan, Barberà, Albert, Télémaque-Potts, Sabine, Newgard, Christopher B., Guinovart, Joan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals carbohydrate metabolism Cells, Cultured chemical composition diabetes Diabetes Mellitus, Type 2 - metabolism enzyme activity fructose-2,6-bisphosphate gene expression gene overexpression glucokinase Glucokinase - biosynthesis glucose Glucose - metabolism glucose 6-phosphate glycogen glycogen (starch) synthase Glycogen Synthase - metabolism Glycolysis hepatocytes lactic acid Lactic Acid - biosynthesis Liver - metabolism Liver Glycogen - biosynthesis Male Phosphorylation pyruvate kinase Rats Rats, Zucker sugar phosphates transgenic animals
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