Localization of Chromogranin, Synaptophysin, Serotonin, and CXCR2 in Neuroendocrine Cells of the Minor Vestibular Glands: An Immunohistochemical Study
Sections of vulvar tissue containing minor vestibular glands (15 sections from 14 women with vulvar vestibulitis syndrome and six control sections from five asymptomatic women) were immunohistochemically stained with antibodies against chromogranin. synaptophysin, serotonin, and CXCR2. The degree of...
Gespeichert in:
| Veröffentlicht in: | International journal of gynecological pathology 1999-10, Vol.18 (4), p.360-365 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 365 |
|---|---|
| container_issue | 4 |
| container_start_page | 360 |
| container_title | International journal of gynecological pathology |
| container_volume | 18 |
| creator | Slone, Stephen Reynolds, Lynval Gall, Stanley Peiper, Stephen Martin, Alvin Ackermann, Douglas OʼConnor, Dennis |
| description | Sections of vulvar tissue containing minor vestibular glands (15 sections from 14 women with vulvar vestibulitis syndrome and six control sections from five asymptomatic women) were immunohistochemically stained with antibodies against chromogranin. synaptophysin, serotonin, and CXCR2. The degree of inflammation in vestibular tissue from women with and without vulvar vestibulitis syndrome was not significantly different. All vulvar minor vestibular glands contained neuroendocrine cells that expressed chromogranin to some degree. Only one case failed to express synaptophysin. The number of cells expressing chromogranin and synaptophysin was the same regardless of the degree of inflammation. However, moderate to severe inflammation was associated with a statistically significant increase in the number of cells expressing serotonin (p < 0.001) and CXCR2 (p < 0.02). It is concluded that neuroendocrine cells are present within minor vestibular glands of the vulva. The number of cells expressing the inflammatory mediator serotonin and CXCR2. the shared interleukin-8 receptor. are upregulated with inflammation. Chronic inflammation is a normal finding in vestibular tissue and does not serve as a histologic marker for vulvar vestibulitis. |
| doi_str_mv | 10.1097/00004347-199910000-00011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69225614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69225614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3301-ef4ad3590f2bbc4638b11a1840865cdaa3c85de987583457696a8828cc472a693</originalsourceid><addsrcrecordid>eNp1kttu1DAQhi0EosvCKyBfIK4IZOJDbO6qCNpKC0gUEHeW4zjEkNhbO1G1PAjPW--Bww0jWdbI38z8mt8IYShfQinrV2UOSmhdgJQS9lmRD8A9tAJGRFEDg_toVVZ1RriEM_Qope-Z4MDrh-gMSkYrSdkK_doEo0f3U88ueBx63AwxTOFb1N75F_h65_V2Dtthlw6pjWEOhxftO9x8bT5W2Hn83i4xWN8FE523uLHjmPbN5sHid86HiL_YNLt2GXXEF2OuTa_xucdX07T4MLg0BzPYyWUp-Hpeut1j9KDXY7JPTvcafX775lNzWWw-XFw155vCEFJCYXuqO8Jk2VdtaygnogXQIGgpODOd1sQI1lkpaiYIZTWXXAtRCWNoXWkuyRo9P_bdxnCzZI1qcslk-drbsCTFZVUxDjSD4giaGFKKtlfb6CYddwpKtfdE_fZE_fFEHTzJpU9PM5Z2st0_hUcTMvDsBOiUN9Dn3RuX_nIggeRYI3rEbsM425h-jMutjWqwepwH9b8vQe4AeO6kjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69225614</pqid></control><display><type>article</type><title>Localization of Chromogranin, Synaptophysin, Serotonin, and CXCR2 in Neuroendocrine Cells of the Minor Vestibular Glands: An Immunohistochemical Study</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Slone, Stephen ; Reynolds, Lynval ; Gall, Stanley ; Peiper, Stephen ; Martin, Alvin ; Ackermann, Douglas ; OʼConnor, Dennis</creator><creatorcontrib>Slone, Stephen ; Reynolds, Lynval ; Gall, Stanley ; Peiper, Stephen ; Martin, Alvin ; Ackermann, Douglas ; OʼConnor, Dennis</creatorcontrib><description>Sections of vulvar tissue containing minor vestibular glands (15 sections from 14 women with vulvar vestibulitis syndrome and six control sections from five asymptomatic women) were immunohistochemically stained with antibodies against chromogranin. synaptophysin, serotonin, and CXCR2. The degree of inflammation in vestibular tissue from women with and without vulvar vestibulitis syndrome was not significantly different. All vulvar minor vestibular glands contained neuroendocrine cells that expressed chromogranin to some degree. Only one case failed to express synaptophysin. The number of cells expressing chromogranin and synaptophysin was the same regardless of the degree of inflammation. However, moderate to severe inflammation was associated with a statistically significant increase in the number of cells expressing serotonin (p < 0.001) and CXCR2 (p < 0.02). It is concluded that neuroendocrine cells are present within minor vestibular glands of the vulva. The number of cells expressing the inflammatory mediator serotonin and CXCR2. the shared interleukin-8 receptor. are upregulated with inflammation. Chronic inflammation is a normal finding in vestibular tissue and does not serve as a histologic marker for vulvar vestibulitis.</description><identifier>ISSN: 0277-1691</identifier><identifier>EISSN: 1538-7151</identifier><identifier>DOI: 10.1097/00004347-199910000-00011</identifier><identifier>PMID: 10542945</identifier><identifier>CODEN: IJGPDR</identifier><language>eng</language><publisher>Philadelphia, PA: International Society of Gynecological Pathologists</publisher><subject>Adult ; Biological and medical sciences ; Chromogranins - biosynthesis ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Inflammation - pathology ; Medical sciences ; Middle Aged ; Neurosecretory Systems - cytology ; Neurosecretory Systems - metabolism ; Non tumoral diseases ; Receptors, Chemokine - biosynthesis ; Receptors, Interleukin - biosynthesis ; Receptors, Interleukin-8B ; Serotonin - biosynthesis ; Synaptophysin - biosynthesis ; Vulva - innervation ; Vulva - metabolism ; Vulvitis - metabolism ; Vulvitis - pathology</subject><ispartof>International journal of gynecological pathology, 1999-10, Vol.18 (4), p.360-365</ispartof><rights>1999International Society of Gynecological Pathologists</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1191333$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10542945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slone, Stephen</creatorcontrib><creatorcontrib>Reynolds, Lynval</creatorcontrib><creatorcontrib>Gall, Stanley</creatorcontrib><creatorcontrib>Peiper, Stephen</creatorcontrib><creatorcontrib>Martin, Alvin</creatorcontrib><creatorcontrib>Ackermann, Douglas</creatorcontrib><creatorcontrib>OʼConnor, Dennis</creatorcontrib><title>Localization of Chromogranin, Synaptophysin, Serotonin, and CXCR2 in Neuroendocrine Cells of the Minor Vestibular Glands: An Immunohistochemical Study</title><title>International journal of gynecological pathology</title><addtitle>Int J Gynecol Pathol</addtitle><description>Sections of vulvar tissue containing minor vestibular glands (15 sections from 14 women with vulvar vestibulitis syndrome and six control sections from five asymptomatic women) were immunohistochemically stained with antibodies against chromogranin. synaptophysin, serotonin, and CXCR2. The degree of inflammation in vestibular tissue from women with and without vulvar vestibulitis syndrome was not significantly different. All vulvar minor vestibular glands contained neuroendocrine cells that expressed chromogranin to some degree. Only one case failed to express synaptophysin. The number of cells expressing chromogranin and synaptophysin was the same regardless of the degree of inflammation. However, moderate to severe inflammation was associated with a statistically significant increase in the number of cells expressing serotonin (p < 0.001) and CXCR2 (p < 0.02). It is concluded that neuroendocrine cells are present within minor vestibular glands of the vulva. The number of cells expressing the inflammatory mediator serotonin and CXCR2. the shared interleukin-8 receptor. are upregulated with inflammation. Chronic inflammation is a normal finding in vestibular tissue and does not serve as a histologic marker for vulvar vestibulitis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chromogranins - biosynthesis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurosecretory Systems - cytology</subject><subject>Neurosecretory Systems - metabolism</subject><subject>Non tumoral diseases</subject><subject>Receptors, Chemokine - biosynthesis</subject><subject>Receptors, Interleukin - biosynthesis</subject><subject>Receptors, Interleukin-8B</subject><subject>Serotonin - biosynthesis</subject><subject>Synaptophysin - biosynthesis</subject><subject>Vulva - innervation</subject><subject>Vulva - metabolism</subject><subject>Vulvitis - metabolism</subject><subject>Vulvitis - pathology</subject><issn>0277-1691</issn><issn>1538-7151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kttu1DAQhi0EosvCKyBfIK4IZOJDbO6qCNpKC0gUEHeW4zjEkNhbO1G1PAjPW--Bww0jWdbI38z8mt8IYShfQinrV2UOSmhdgJQS9lmRD8A9tAJGRFEDg_toVVZ1RriEM_Qope-Z4MDrh-gMSkYrSdkK_doEo0f3U88ueBx63AwxTOFb1N75F_h65_V2Dtthlw6pjWEOhxftO9x8bT5W2Hn83i4xWN8FE523uLHjmPbN5sHid86HiL_YNLt2GXXEF2OuTa_xucdX07T4MLg0BzPYyWUp-Hpeut1j9KDXY7JPTvcafX775lNzWWw-XFw155vCEFJCYXuqO8Jk2VdtaygnogXQIGgpODOd1sQI1lkpaiYIZTWXXAtRCWNoXWkuyRo9P_bdxnCzZI1qcslk-drbsCTFZVUxDjSD4giaGFKKtlfb6CYddwpKtfdE_fZE_fFEHTzJpU9PM5Z2st0_hUcTMvDsBOiUN9Dn3RuX_nIggeRYI3rEbsM425h-jMutjWqwepwH9b8vQe4AeO6kjw</recordid><startdate>199910</startdate><enddate>199910</enddate><creator>Slone, Stephen</creator><creator>Reynolds, Lynval</creator><creator>Gall, Stanley</creator><creator>Peiper, Stephen</creator><creator>Martin, Alvin</creator><creator>Ackermann, Douglas</creator><creator>OʼConnor, Dennis</creator><general>International Society of Gynecological Pathologists</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199910</creationdate><title>Localization of Chromogranin, Synaptophysin, Serotonin, and CXCR2 in Neuroendocrine Cells of the Minor Vestibular Glands: An Immunohistochemical Study</title><author>Slone, Stephen ; Reynolds, Lynval ; Gall, Stanley ; Peiper, Stephen ; Martin, Alvin ; Ackermann, Douglas ; OʼConnor, Dennis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3301-ef4ad3590f2bbc4638b11a1840865cdaa3c85de987583457696a8828cc472a693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chromogranins - biosynthesis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammation - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurosecretory Systems - cytology</topic><topic>Neurosecretory Systems - metabolism</topic><topic>Non tumoral diseases</topic><topic>Receptors, Chemokine - biosynthesis</topic><topic>Receptors, Interleukin - biosynthesis</topic><topic>Receptors, Interleukin-8B</topic><topic>Serotonin - biosynthesis</topic><topic>Synaptophysin - biosynthesis</topic><topic>Vulva - innervation</topic><topic>Vulva - metabolism</topic><topic>Vulvitis - metabolism</topic><topic>Vulvitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slone, Stephen</creatorcontrib><creatorcontrib>Reynolds, Lynval</creatorcontrib><creatorcontrib>Gall, Stanley</creatorcontrib><creatorcontrib>Peiper, Stephen</creatorcontrib><creatorcontrib>Martin, Alvin</creatorcontrib><creatorcontrib>Ackermann, Douglas</creatorcontrib><creatorcontrib>OʼConnor, Dennis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecological pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slone, Stephen</au><au>Reynolds, Lynval</au><au>Gall, Stanley</au><au>Peiper, Stephen</au><au>Martin, Alvin</au><au>Ackermann, Douglas</au><au>OʼConnor, Dennis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of Chromogranin, Synaptophysin, Serotonin, and CXCR2 in Neuroendocrine Cells of the Minor Vestibular Glands: An Immunohistochemical Study</atitle><jtitle>International journal of gynecological pathology</jtitle><addtitle>Int J Gynecol Pathol</addtitle><date>1999-10</date><risdate>1999</risdate><volume>18</volume><issue>4</issue><spage>360</spage><epage>365</epage><pages>360-365</pages><issn>0277-1691</issn><eissn>1538-7151</eissn><coden>IJGPDR</coden><abstract>Sections of vulvar tissue containing minor vestibular glands (15 sections from 14 women with vulvar vestibulitis syndrome and six control sections from five asymptomatic women) were immunohistochemically stained with antibodies against chromogranin. synaptophysin, serotonin, and CXCR2. The degree of inflammation in vestibular tissue from women with and without vulvar vestibulitis syndrome was not significantly different. All vulvar minor vestibular glands contained neuroendocrine cells that expressed chromogranin to some degree. Only one case failed to express synaptophysin. The number of cells expressing chromogranin and synaptophysin was the same regardless of the degree of inflammation. However, moderate to severe inflammation was associated with a statistically significant increase in the number of cells expressing serotonin (p < 0.001) and CXCR2 (p < 0.02). It is concluded that neuroendocrine cells are present within minor vestibular glands of the vulva. The number of cells expressing the inflammatory mediator serotonin and CXCR2. the shared interleukin-8 receptor. are upregulated with inflammation. Chronic inflammation is a normal finding in vestibular tissue and does not serve as a histologic marker for vulvar vestibulitis.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>International Society of Gynecological Pathologists</pub><pmid>10542945</pmid><doi>10.1097/00004347-199910000-00011</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-1691 |
| ispartof | International journal of gynecological pathology, 1999-10, Vol.18 (4), p.360-365 |
| issn | 0277-1691 1538-7151 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69225614 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Chromogranins - biosynthesis Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Inflammation - pathology Medical sciences Middle Aged Neurosecretory Systems - cytology Neurosecretory Systems - metabolism Non tumoral diseases Receptors, Chemokine - biosynthesis Receptors, Interleukin - biosynthesis Receptors, Interleukin-8B Serotonin - biosynthesis Synaptophysin - biosynthesis Vulva - innervation Vulva - metabolism Vulvitis - metabolism Vulvitis - pathology |
| title | Localization of Chromogranin, Synaptophysin, Serotonin, and CXCR2 in Neuroendocrine Cells of the Minor Vestibular Glands: An Immunohistochemical Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T12%3A15%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Localization%20of%20Chromogranin,%20Synaptophysin,%20Serotonin,%20and%20CXCR2%20in%20Neuroendocrine%20Cells%20of%20the%20Minor%20Vestibular%20Glands:%20An%20Immunohistochemical%20Study&rft.jtitle=International%20journal%20of%20gynecological%20pathology&rft.au=Slone,%20Stephen&rft.date=1999-10&rft.volume=18&rft.issue=4&rft.spage=360&rft.epage=365&rft.pages=360-365&rft.issn=0277-1691&rft.eissn=1538-7151&rft.coden=IJGPDR&rft_id=info:doi/10.1097/00004347-199910000-00011&rft_dat=%3Cproquest_cross%3E69225614%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69225614&rft_id=info:pmid/10542945&rfr_iscdi=true |