20-O-β-Glucopyranosyl Camptothecin from Mostuea brunonis: A Potential Camptothecin Pro-Drug with Improved Solubility

Bioassay-guided fractionation of the organic extracts of whole plants of Mostuea brunonis (Loganiaceae), using the National Cancer Institute's (NCI) human tumor-based in vitro antitumor screen, led to the isolation and identification of camptothecin 20-O-β-d-glucoside (1) and three moderately c...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-10, Vol.62 (10), p.1427-1429
Hauptverfasser:	Dai, Jin-Rui, Hallock, Yali F, Cardellina, John H, Boyd, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	2'-o-acetylstrictosamide antineoplastic agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Biological and medical sciences campthecin Camptothecin - analogs & derivatives Camptothecin - chemistry Camptothecin - isolation & purification Camptothecin - pharmacology chemical constituents of plants chemical structure cytotoxic compounds deoxypumiloside Drug Screening Assays, Antitumor General pharmacology Humans indole alkaloids Loganiaceae Magnetic Resonance Spectroscopy Mass Spectrometry - methods Medical sciences medicinal plants Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants - chemistry Prodrugs - chemistry Prodrugs - isolation & purification quinoline alkaloids spectral analysis strictosamide Tumor Cells, Cultured
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