A Phase 1 Study to Evaluate the Safety and Immunogenicity of a Recombinant HIV Type 1 Subtype C Adeno-Associated Virus Vaccine

A novel prophylactic AIDS vaccine candidate, consisting of single-stranded DNA for HIV-1 subtype C gag, protease, and part of reverse transcriptase genes, enclosed within a recombinant adeno-associated virus serotype-2 protein capsid (tgAAC09) induced T cell responses and antibodies in nonhuman prim...

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Veröffentlicht in:	AIDS research and human retroviruses 2008-06, Vol.24 (6), p.873-880
Hauptverfasser:	MEHENDALE, Sanjay, VAN LUNZEN, Jan, LEHRMAN, Jennifer, SCHMIDT, Claudia, PEETERS, Mathieu, SCHWARZE-ZANDER, Carolynne, KABAMBA, Kabeya, GLAUNSINGER, Tobias, SAHAY, Seema, THAKAR, Madhuri, PARANJAPE, Ramesh, GILMOUR, Jill, CLUMECK, Nathan, EXCLER, Jean-Louis, FAST, Patricia, HEALD, Alison E, ROCKSTROH, Jurgen, VETS, Eva, JOHNSON, Philip R, ANKLESARIA, Pervin, BARIN, Burc, BOAZ, Mark, KOCHHAR, Sonali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AIDS Vaccines - administration & dosage AIDS Vaccines - adverse effects AIDS/HIV Antibody Formation Biological and medical sciences Capsid - immunology Dependovirus - immunology DNA, Viral - administration & dosage Double-Blind Method Female Fundamental and applied biological sciences. Psychology gag Gene Products, Human Immunodeficiency Virus - immunology Health aspects HIV infection HIV Infections - prevention & control HIV-1 - immunology Human viral diseases Humans Immunity, Cellular Immunization, Secondary Infectious diseases Injections, Intramuscular Interferon-gamma - blood Male Medical sciences Microbiology Middle Aged Miscellaneous Neutralization Tests Physiological aspects Prevention T-Lymphocytes - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - administration & dosage Vaccines, DNA - adverse effects Vaccines, DNA - immunology Vaccines, Virosome - administration & dosage Vaccines, Virosome - adverse effects Viral diseases Viral vaccines Virology
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