Novel steroid receptor phyto-modulator compound a inhibits growth and survival of prostate cancer cells

Androgen receptor (AR)- and glucocorticoid receptor (GR)- mediated signaling play opposite roles in prostate tumorigenesis: AR promotes prostate carcinoma (PC) development, whereas GR acts as a tumor suppressor. Compound A (CpdA) is a stable analogue of an aziridine precursor from the African shrub...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-06, Vol.68 (12), p.4763-4773
Hauptverfasser:	Yemelyanov, Alexander, Czwornog, Jennifer, Gera, Lajos, Joshi, Sonali, Chatterton, Jr, Robert T, Budunova, Irina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemical synthesis Acetates - pharmacology Androgen Antagonists - pharmacology Androgens - pharmacology Apoptosis - drug effects Blotting, Western Cell Proliferation - drug effects Colony-Forming Units Assay Electrophoretic Mobility Shift Assay Ethylamines - chemical synthesis Ethylamines - pharmacology Humans Hydrogen Bonding Luciferases - metabolism Male Prostate-Specific Antigen - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Radioligand Assay Receptors, Androgen - genetics Receptors, Androgen - metabolism Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism RNA, Small Interfering - pharmacology Salsola Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection Tumor Cells, Cultured Tyramine - analogs & derivatives
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