Bacteremia Associated With Toothbrushing and Dental Extraction
Antibiotic prophylaxis recommendations for the prevention of infective endocarditis are based in part on studies of bacteremia from dental procedures, but toothbrushing may pose a greater threat. The purpose of this study was to compare the incidence, duration, nature, and magnitude of endocarditis-...
Gespeichert in:
| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2008-06, Vol.117 (24), p.3118-3125 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3125 |
|---|---|
| container_issue | 24 |
| container_start_page | 3118 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 117 |
| creator | LOCKHART, Peter B BRENNAN, Michael T SASSER, Howell C FOX, Philip C PASTER, Bruce J BAHRANI-MOUGEOT, Farah K |
| description | Antibiotic prophylaxis recommendations for the prevention of infective endocarditis are based in part on studies of bacteremia from dental procedures, but toothbrushing may pose a greater threat. The purpose of this study was to compare the incidence, duration, nature, and magnitude of endocarditis-related bacteremia from single-tooth extraction and toothbrushing and to determine the impact of amoxicillin prophylaxis on single-tooth extraction.
In this double-blind, placebo-controlled study, 290 subjects were randomized to (1) toothbrushing, (2) single-tooth extraction with amoxicillin prophylaxis, or (3) single-tooth extraction with identical placebo. Blood was drawn for bacterial culturing and identification at 6 time points before, during, and after these interventions. The focus of our analysis was on bacterial species reported to cause infective endocarditis. We identified 98 bacterial species, 32 of which are reported to cause endocarditis. Cumulative incidence of endocarditis-related bacteria from all 6 blood draws was 23%, 33%, and 60% for the toothbrushing, extraction-amoxicillin, and extraction-placebo groups, respectively (P |
| doi_str_mv | 10.1161/CIRCULATIONAHA.107.758524 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69223752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20850710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-b9681adc227cc846051c61225a27c54e7f82cac7b2259b1455bc7fc49ab8d9b43</originalsourceid><addsrcrecordid>eNqFkFFLwzAUhYMobk7_gtQHfetM0qRpXoRapxsMB7LhY0nS1EW6VpMU9N8bWVF88ulyD985l3sAuEBwilCKrovFU7FZ5uvF6jGf51ME2ZTRjGJyAMYojJjQhB-CMYSQxyzBeAROnHsNa5owegxGKKMEsYSPwc2tUF5bvTMiyp3rlBFeV9Gz8dto3XV-K23vtqZ9iURbRXe69aKJZh_eBpvp2lNwVIvG6bNhTsDmfrYu5vFy9bAo8mWsKE59LHmaIVEpjJlSGUkhRSpFGFMRBEo0qzOshGIySFwiQqlUrFaEC5lVXJJkAq72uW-2e--18-XOOKWbRrS6612ZcozDa_hfEMOMQoZgAPkeVLZzzuq6fLNmJ-xniWD53XL5t-Ugs3LfcvCeD0d6udPVr3OoNQCXAyCcEk1tRauM--EwJCEGJ8kXmzaGPg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20850710</pqid></control><display><type>article</type><title>Bacteremia Associated With Toothbrushing and Dental Extraction</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>LOCKHART, Peter B ; BRENNAN, Michael T ; SASSER, Howell C ; FOX, Philip C ; PASTER, Bruce J ; BAHRANI-MOUGEOT, Farah K</creator><creatorcontrib>LOCKHART, Peter B ; BRENNAN, Michael T ; SASSER, Howell C ; FOX, Philip C ; PASTER, Bruce J ; BAHRANI-MOUGEOT, Farah K</creatorcontrib><description>Antibiotic prophylaxis recommendations for the prevention of infective endocarditis are based in part on studies of bacteremia from dental procedures, but toothbrushing may pose a greater threat. The purpose of this study was to compare the incidence, duration, nature, and magnitude of endocarditis-related bacteremia from single-tooth extraction and toothbrushing and to determine the impact of amoxicillin prophylaxis on single-tooth extraction.
In this double-blind, placebo-controlled study, 290 subjects were randomized to (1) toothbrushing, (2) single-tooth extraction with amoxicillin prophylaxis, or (3) single-tooth extraction with identical placebo. Blood was drawn for bacterial culturing and identification at 6 time points before, during, and after these interventions. The focus of our analysis was on bacterial species reported to cause infective endocarditis. We identified 98 bacterial species, 32 of which are reported to cause endocarditis. Cumulative incidence of endocarditis-related bacteria from all 6 blood draws was 23%, 33%, and 60% for the toothbrushing, extraction-amoxicillin, and extraction-placebo groups, respectively (P<0.0001). Significant differences were identified among the 3 groups at draws 2, 3, 4, and 5 (all P<0.05). Amoxicillin resulted in a significant decrease in positive cultures (P<0.0001).
Although amoxicillin has a significant impact on bacteremia resulting from a single-tooth extraction, given the greater frequency for oral hygiene, toothbrushing may be a greater threat for individuals at risk for infective endocarditis.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.107.758524</identifier><identifier>PMID: 18541739</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Amoxicillin - therapeutic use ; Anti-Bacterial Agents - therapeutic use ; Bacteremia - blood ; Bacteremia - epidemiology ; Bacteremia - prevention & control ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Dental Plaque - epidemiology ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Double-Blind Method ; Ethnic Groups ; Female ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Neurology ; Oral Hygiene - standards ; Patient Selection ; Placebos ; Tooth Extraction - adverse effects ; Toothbrushing - adverse effects ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Circulation (New York, N.Y.), 2008-06, Vol.117 (24), p.3118-3125</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b9681adc227cc846051c61225a27c54e7f82cac7b2259b1455bc7fc49ab8d9b43</citedby><cites>FETCH-LOGICAL-c526t-b9681adc227cc846051c61225a27c54e7f82cac7b2259b1455bc7fc49ab8d9b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20452423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18541739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOCKHART, Peter B</creatorcontrib><creatorcontrib>BRENNAN, Michael T</creatorcontrib><creatorcontrib>SASSER, Howell C</creatorcontrib><creatorcontrib>FOX, Philip C</creatorcontrib><creatorcontrib>PASTER, Bruce J</creatorcontrib><creatorcontrib>BAHRANI-MOUGEOT, Farah K</creatorcontrib><title>Bacteremia Associated With Toothbrushing and Dental Extraction</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Antibiotic prophylaxis recommendations for the prevention of infective endocarditis are based in part on studies of bacteremia from dental procedures, but toothbrushing may pose a greater threat. The purpose of this study was to compare the incidence, duration, nature, and magnitude of endocarditis-related bacteremia from single-tooth extraction and toothbrushing and to determine the impact of amoxicillin prophylaxis on single-tooth extraction.
In this double-blind, placebo-controlled study, 290 subjects were randomized to (1) toothbrushing, (2) single-tooth extraction with amoxicillin prophylaxis, or (3) single-tooth extraction with identical placebo. Blood was drawn for bacterial culturing and identification at 6 time points before, during, and after these interventions. The focus of our analysis was on bacterial species reported to cause infective endocarditis. We identified 98 bacterial species, 32 of which are reported to cause endocarditis. Cumulative incidence of endocarditis-related bacteria from all 6 blood draws was 23%, 33%, and 60% for the toothbrushing, extraction-amoxicillin, and extraction-placebo groups, respectively (P<0.0001). Significant differences were identified among the 3 groups at draws 2, 3, 4, and 5 (all P<0.05). Amoxicillin resulted in a significant decrease in positive cultures (P<0.0001).
Although amoxicillin has a significant impact on bacteremia resulting from a single-tooth extraction, given the greater frequency for oral hygiene, toothbrushing may be a greater threat for individuals at risk for infective endocarditis.</description><subject>Adult</subject><subject>Amoxicillin - therapeutic use</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacteremia - blood</subject><subject>Bacteremia - epidemiology</subject><subject>Bacteremia - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Dental Plaque - epidemiology</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Double-Blind Method</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Oral Hygiene - standards</subject><subject>Patient Selection</subject><subject>Placebos</subject><subject>Tooth Extraction - adverse effects</subject><subject>Toothbrushing - adverse effects</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFFLwzAUhYMobk7_gtQHfetM0qRpXoRapxsMB7LhY0nS1EW6VpMU9N8bWVF88ulyD985l3sAuEBwilCKrovFU7FZ5uvF6jGf51ME2ZTRjGJyAMYojJjQhB-CMYSQxyzBeAROnHsNa5owegxGKKMEsYSPwc2tUF5bvTMiyp3rlBFeV9Gz8dto3XV-K23vtqZ9iURbRXe69aKJZh_eBpvp2lNwVIvG6bNhTsDmfrYu5vFy9bAo8mWsKE59LHmaIVEpjJlSGUkhRSpFGFMRBEo0qzOshGIySFwiQqlUrFaEC5lVXJJkAq72uW-2e--18-XOOKWbRrS6612ZcozDa_hfEMOMQoZgAPkeVLZzzuq6fLNmJ-xniWD53XL5t-Ugs3LfcvCeD0d6udPVr3OoNQCXAyCcEk1tRauM--EwJCEGJ8kXmzaGPg</recordid><startdate>20080617</startdate><enddate>20080617</enddate><creator>LOCKHART, Peter B</creator><creator>BRENNAN, Michael T</creator><creator>SASSER, Howell C</creator><creator>FOX, Philip C</creator><creator>PASTER, Bruce J</creator><creator>BAHRANI-MOUGEOT, Farah K</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20080617</creationdate><title>Bacteremia Associated With Toothbrushing and Dental Extraction</title><author>LOCKHART, Peter B ; BRENNAN, Michael T ; SASSER, Howell C ; FOX, Philip C ; PASTER, Bruce J ; BAHRANI-MOUGEOT, Farah K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-b9681adc227cc846051c61225a27c54e7f82cac7b2259b1455bc7fc49ab8d9b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Amoxicillin - therapeutic use</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteremia - blood</topic><topic>Bacteremia - epidemiology</topic><topic>Bacteremia - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Dental Plaque - epidemiology</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Double-Blind Method</topic><topic>Ethnic Groups</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Oral Hygiene - standards</topic><topic>Patient Selection</topic><topic>Placebos</topic><topic>Tooth Extraction - adverse effects</topic><topic>Toothbrushing - adverse effects</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOCKHART, Peter B</creatorcontrib><creatorcontrib>BRENNAN, Michael T</creatorcontrib><creatorcontrib>SASSER, Howell C</creatorcontrib><creatorcontrib>FOX, Philip C</creatorcontrib><creatorcontrib>PASTER, Bruce J</creatorcontrib><creatorcontrib>BAHRANI-MOUGEOT, Farah K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOCKHART, Peter B</au><au>BRENNAN, Michael T</au><au>SASSER, Howell C</au><au>FOX, Philip C</au><au>PASTER, Bruce J</au><au>BAHRANI-MOUGEOT, Farah K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacteremia Associated With Toothbrushing and Dental Extraction</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2008-06-17</date><risdate>2008</risdate><volume>117</volume><issue>24</issue><spage>3118</spage><epage>3125</epage><pages>3118-3125</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Antibiotic prophylaxis recommendations for the prevention of infective endocarditis are based in part on studies of bacteremia from dental procedures, but toothbrushing may pose a greater threat. The purpose of this study was to compare the incidence, duration, nature, and magnitude of endocarditis-related bacteremia from single-tooth extraction and toothbrushing and to determine the impact of amoxicillin prophylaxis on single-tooth extraction.
In this double-blind, placebo-controlled study, 290 subjects were randomized to (1) toothbrushing, (2) single-tooth extraction with amoxicillin prophylaxis, or (3) single-tooth extraction with identical placebo. Blood was drawn for bacterial culturing and identification at 6 time points before, during, and after these interventions. The focus of our analysis was on bacterial species reported to cause infective endocarditis. We identified 98 bacterial species, 32 of which are reported to cause endocarditis. Cumulative incidence of endocarditis-related bacteria from all 6 blood draws was 23%, 33%, and 60% for the toothbrushing, extraction-amoxicillin, and extraction-placebo groups, respectively (P<0.0001). Significant differences were identified among the 3 groups at draws 2, 3, 4, and 5 (all P<0.05). Amoxicillin resulted in a significant decrease in positive cultures (P<0.0001).
Although amoxicillin has a significant impact on bacteremia resulting from a single-tooth extraction, given the greater frequency for oral hygiene, toothbrushing may be a greater threat for individuals at risk for infective endocarditis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18541739</pmid><doi>10.1161/CIRCULATIONAHA.107.758524</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2008-06, Vol.117 (24), p.3118-3125 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69223752 |
| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Amoxicillin - therapeutic use Anti-Bacterial Agents - therapeutic use Bacteremia - blood Bacteremia - epidemiology Bacteremia - prevention & control Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Dental Plaque - epidemiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Double-Blind Method Ethnic Groups Female Humans Incidence Male Medical sciences Middle Aged Neurology Oral Hygiene - standards Patient Selection Placebos Tooth Extraction - adverse effects Toothbrushing - adverse effects Vascular diseases and vascular malformations of the nervous system |
| title | Bacteremia Associated With Toothbrushing and Dental Extraction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T07%3A18%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bacteremia%20Associated%20With%20Toothbrushing%20and%20Dental%20Extraction&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=LOCKHART,%20Peter%20B&rft.date=2008-06-17&rft.volume=117&rft.issue=24&rft.spage=3118&rft.epage=3125&rft.pages=3118-3125&rft.issn=0009-7322&rft.eissn=1524-4539&rft.coden=CIRCAZ&rft_id=info:doi/10.1161/CIRCULATIONAHA.107.758524&rft_dat=%3Cproquest_cross%3E20850710%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20850710&rft_id=info:pmid/18541739&rfr_iscdi=true |