Immobilized DNA Switches as Electronic Sensors for Picomolar Detection of Plasma Proteins

The sensing principle of a new class of DNA conformational switches (deoxyribosensors) is based on the incorporation of an aptamer as the receptor, whose altered conformation upon analyte binding switches on the conductivity of an adjacent helical conduction path, leading to an increase in the measu...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-06, Vol.130 (25), p.8023-8029
Hauptverfasser:	Huang, Yu Chuan, Ge, Bixia, Sen, Dipankar, Yu, Hua-Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Proteins - analysis Blood Proteins - chemistry DNA - chemistry Electrochemistry Microchemistry Microchip Analytical Procedures Models, Biological Thrombin - analysis Thrombin - chemistry
Online-Zugang:	Volltext
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