HLA Homology within the C5 Domain Promotes Peptide Binding by HIV Type 1 gp120

The mechanisms by which HIV-1 induces chronic pathogenic immune activation associated with disease progression remain unclear despite many years of AIDS research. One proposal suggests that sequence and structural mimicry between gp120 and HLA may endow HIV with the capacity to arouse alloreactive a...

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Veröffentlicht in:	AIDS research and human retroviruses 2008-06, Vol.24 (6), p.845-855
Hauptverfasser:	CADOGAN, Martin, AUSTEN, Brian, HEENEY, Jonathan L, DALGLEISH, Angus G
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS (Disease) AIDS/HIV Antibodies, Monoclonal - metabolism Binding Sites Biological and medical sciences CD4 Antigens - immunology CD4 Antigens - metabolism Control Distribution DNA-ligand interactions Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Histocompatibility antigens HIV Antibodies - immunology HIV Antibodies - metabolism HIV Envelope Protein gp120 - immunology HIV-1 - immunology HIV-1 - metabolism HLA histocompatibility antigens HLA-A2 Antigen - immunology HLA-A2 Antigen - metabolism HLA-DR1 Antigen - immunology HLA-DR1 Antigen - metabolism Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Lymphocyte Activation Medical sciences Microbiology Miscellaneous Models, Molecular Molecular Mimicry Physiological aspects Protein Interaction Domains and Motifs Retrovirus Risk factors Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Viral diseases Virology
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