Evolutionary relationships between sporadic and epidemic strains of healthcare-associated methicillin-resistant Staphylococcus aureus
ABSTRACT National surveillance of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates by pulsed-field gel electrophoresis (PFGE) typing allowed identification of rarely occurring ‘sporadic’ isolates with patterns significantly distinct from those of major epidemic cl...
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| Veröffentlicht in: | Clinical microbiology and infection 2008-07, Vol.14 (7), p.659-669 |
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| creator | Hallin, M. Denis, O. Deplano, A. De Ryck, R. Crèvecoeur, S. Rottiers, S. de Mendonça, R. Struelens, M.J. |
| description | ABSTRACT
National surveillance of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates by pulsed-field gel electrophoresis (PFGE) typing allowed identification of rarely occurring ‘sporadic’ isolates with patterns significantly distinct from those of major epidemic clones of methicillin-resistant S. aureus (MRSA) circulating in Belgian hospitals. The aim of the present study was to compare the genetic background, antibiotic susceptibility profile and in vitro growth rates of 36 MRSA isolates with either ‘epidemic’ or ‘sporadic’ PFGE profiles to identify factors that could be involved in the epidemic behaviour of S. aureus. Sequence analysis of seven housekeeping genes (multilocus sequence typing) and seven surface-associated genes, combined with staphylococcal cassette chromosome mec (SCCmec) typing and spa typing results, segregated sporadic isolates into four groups: (1) isolates phylogenetically distant from epidemic HA-MRSA clones that possessed several properties of community-acquired MRSA strains; (2) isolates derived from the same methicillin-susceptible S. aureus ancestor as epidemic isolates but possessing a distinct type of SCCmec; and (3) and (4) isolates that were closely related to epidemic strains, either as recent descendants of these or as intermediate evolutionary steps between epidemic HA-MRSA strains and their putative ancestors. Sporadic isolates did not show slower growth in vitro than epidemic isolates. These findings suggest that the SCCmec type and insertion/deletion of other mobile genetic elements may be involved in modulating the epidemic behaviour of MRSA strains of similar genetic background, independently of fitness cost. |
| doi_str_mv | 10.1111/j.1469-0691.2008.02015.x |
| format | Article |
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National surveillance of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates by pulsed-field gel electrophoresis (PFGE) typing allowed identification of rarely occurring ‘sporadic’ isolates with patterns significantly distinct from those of major epidemic clones of methicillin-resistant S. aureus (MRSA) circulating in Belgian hospitals. The aim of the present study was to compare the genetic background, antibiotic susceptibility profile and in vitro growth rates of 36 MRSA isolates with either ‘epidemic’ or ‘sporadic’ PFGE profiles to identify factors that could be involved in the epidemic behaviour of S. aureus. Sequence analysis of seven housekeeping genes (multilocus sequence typing) and seven surface-associated genes, combined with staphylococcal cassette chromosome mec (SCCmec) typing and spa typing results, segregated sporadic isolates into four groups: (1) isolates phylogenetically distant from epidemic HA-MRSA clones that possessed several properties of community-acquired MRSA strains; (2) isolates derived from the same methicillin-susceptible S. aureus ancestor as epidemic isolates but possessing a distinct type of SCCmec; and (3) and (4) isolates that were closely related to epidemic strains, either as recent descendants of these or as intermediate evolutionary steps between epidemic HA-MRSA strains and their putative ancestors. Sporadic isolates did not show slower growth in vitro than epidemic isolates. These findings suggest that the SCCmec type and insertion/deletion of other mobile genetic elements may be involved in modulating the epidemic behaviour of MRSA strains of similar genetic background, independently of fitness cost.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2008.02015.x</identifier><identifier>PMID: 18558938</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - pharmacology ; Bacterial diseases ; Bacterial Proteins - genetics ; Bacterial Typing Techniques ; Biological and medical sciences ; Cross Infection - microbiology ; Disease Outbreaks ; DNA, Bacterial - isolation & purification ; Electrophoresis, Gel, Pulsed-Field ; Epidemiology ; evolution ; Evolution, Molecular ; Exfoliatins - genetics ; Genes, Bacterial ; genetic background ; Genotype ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Methicillin Resistance - genetics ; Microbial Sensitivity Tests ; MRSA ; PFGE ; Phylogeny ; Sequence Analysis, DNA ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcal Protein A - genetics ; Staphylococcus aureus ; Staphylococcus aureus - classification ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - genetics ; Staphylococcus aureus - growth & development ; Trans-Activators - genetics ; typing</subject><ispartof>Clinical microbiology and infection, 2008-07, Vol.14 (7), p.659-669</ispartof><rights>2008 European Society of Clinical Infectious Diseases</rights><rights>2008 The Authors. 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National surveillance of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates by pulsed-field gel electrophoresis (PFGE) typing allowed identification of rarely occurring ‘sporadic’ isolates with patterns significantly distinct from those of major epidemic clones of methicillin-resistant S. aureus (MRSA) circulating in Belgian hospitals. The aim of the present study was to compare the genetic background, antibiotic susceptibility profile and in vitro growth rates of 36 MRSA isolates with either ‘epidemic’ or ‘sporadic’ PFGE profiles to identify factors that could be involved in the epidemic behaviour of S. aureus. Sequence analysis of seven housekeeping genes (multilocus sequence typing) and seven surface-associated genes, combined with staphylococcal cassette chromosome mec (SCCmec) typing and spa typing results, segregated sporadic isolates into four groups: (1) isolates phylogenetically distant from epidemic HA-MRSA clones that possessed several properties of community-acquired MRSA strains; (2) isolates derived from the same methicillin-susceptible S. aureus ancestor as epidemic isolates but possessing a distinct type of SCCmec; and (3) and (4) isolates that were closely related to epidemic strains, either as recent descendants of these or as intermediate evolutionary steps between epidemic HA-MRSA strains and their putative ancestors. Sporadic isolates did not show slower growth in vitro than epidemic isolates. 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National surveillance of healthcare-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates by pulsed-field gel electrophoresis (PFGE) typing allowed identification of rarely occurring ‘sporadic’ isolates with patterns significantly distinct from those of major epidemic clones of methicillin-resistant S. aureus (MRSA) circulating in Belgian hospitals. The aim of the present study was to compare the genetic background, antibiotic susceptibility profile and in vitro growth rates of 36 MRSA isolates with either ‘epidemic’ or ‘sporadic’ PFGE profiles to identify factors that could be involved in the epidemic behaviour of S. aureus. Sequence analysis of seven housekeeping genes (multilocus sequence typing) and seven surface-associated genes, combined with staphylococcal cassette chromosome mec (SCCmec) typing and spa typing results, segregated sporadic isolates into four groups: (1) isolates phylogenetically distant from epidemic HA-MRSA clones that possessed several properties of community-acquired MRSA strains; (2) isolates derived from the same methicillin-susceptible S. aureus ancestor as epidemic isolates but possessing a distinct type of SCCmec; and (3) and (4) isolates that were closely related to epidemic strains, either as recent descendants of these or as intermediate evolutionary steps between epidemic HA-MRSA strains and their putative ancestors. Sporadic isolates did not show slower growth in vitro than epidemic isolates. These findings suggest that the SCCmec type and insertion/deletion of other mobile genetic elements may be involved in modulating the epidemic behaviour of MRSA strains of similar genetic background, independently of fitness cost.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>18558938</pmid><doi>10.1111/j.1469-0691.2008.02015.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1198-743X |
| ispartof | Clinical microbiology and infection, 2008-07, Vol.14 (7), p.659-669 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - pharmacology Bacterial diseases Bacterial Proteins - genetics Bacterial Typing Techniques Biological and medical sciences Cross Infection - microbiology Disease Outbreaks DNA, Bacterial - isolation & purification Electrophoresis, Gel, Pulsed-Field Epidemiology evolution Evolution, Molecular Exfoliatins - genetics Genes, Bacterial genetic background Genotype Human bacterial diseases Humans Infectious diseases Medical sciences Methicillin Resistance - genetics Microbial Sensitivity Tests MRSA PFGE Phylogeny Sequence Analysis, DNA Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcal Protein A - genetics Staphylococcus aureus Staphylococcus aureus - classification Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus aureus - growth & development Trans-Activators - genetics typing |
| title | Evolutionary relationships between sporadic and epidemic strains of healthcare-associated methicillin-resistant Staphylococcus aureus |
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