Selected metabolic parameters and the risk for uterine fibroids
Abstract Objective To analyze the possible association between insulin resistance and dyslipidemia with uterine fibroids, using objective metabolic measurements. Method A cross-sectional study of 56 women with uterine fibroids (case group) and 20 women without fibroids (control group). Levels of fas...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2008-07, Vol.102 (1), p.50-54 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Sadlonova, Jana Kostal, Milan Smahelova, Alena Hendl, Jan Starkova, Jitka Nachtigal, Petr |
| description | Abstract Objective To analyze the possible association between insulin resistance and dyslipidemia with uterine fibroids, using objective metabolic measurements. Method A cross-sectional study of 56 women with uterine fibroids (case group) and 20 women without fibroids (control group). Levels of fasting glucose, insulin, C-peptide, sex hormone-binding globulin, and the lipid panel were measured. The short insulin tolerance test was performed. Body mass index, atherogenic index, and the indicator of insulin resistance (Kitt) were also calculated. Results Women with fibroids had significantly higher levels of serum HDL-cholesterol compared with control patients (1.8 ± 0.3 vs 1.6 ± 0.5; P < 0.05). Women with fibroids aged 30–45 years had significantly lower LDL-cholesterol levels than comparative control patients (2.9 ± 0.7 vs 3.4 ± 0.9; P < 0.05). A positive correlation between volume of the largest fibroid and serum HDL-cholesterol level was found in women aged 30–45 years. There were no differences in indicators of insulin resistance between the groups. Conclusion Insulin resistance was not shown to be a risk factor for fibroids. There is a negative association between some parameters of metabolic syndrome and fibroid volume. |
| doi_str_mv | 10.1016/j.ijgo.2008.01.022 |
| format | Article |
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Method A cross-sectional study of 56 women with uterine fibroids (case group) and 20 women without fibroids (control group). Levels of fasting glucose, insulin, C-peptide, sex hormone-binding globulin, and the lipid panel were measured. The short insulin tolerance test was performed. Body mass index, atherogenic index, and the indicator of insulin resistance (Kitt) were also calculated. Results Women with fibroids had significantly higher levels of serum HDL-cholesterol compared with control patients (1.8 ± 0.3 vs 1.6 ± 0.5; P < 0.05). Women with fibroids aged 30–45 years had significantly lower LDL-cholesterol levels than comparative control patients (2.9 ± 0.7 vs 3.4 ± 0.9; P < 0.05). A positive correlation between volume of the largest fibroid and serum HDL-cholesterol level was found in women aged 30–45 years. There were no differences in indicators of insulin resistance between the groups. Conclusion Insulin resistance was not shown to be a risk factor for fibroids. There is a negative association between some parameters of metabolic syndrome and fibroid volume.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2008.01.022</identifier><identifier>PMID: 18336822</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Comorbidity ; Cross-Sectional Studies ; Dyslipidemia ; Dyslipidemias - epidemiology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Leiomyoma - blood ; Leiomyoma - epidemiology ; Leiomyoma - metabolism ; Medical sciences ; Middle Aged ; Obstetrics and Gynecology ; Risk factor ; Tumors ; Uterine fibroids ; Uterine Neoplasms - blood ; Uterine Neoplasms - epidemiology ; Uterine Neoplasms - metabolism</subject><ispartof>International journal of gynecology and obstetrics, 2008-07, Vol.102 (1), p.50-54</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2008 International Federation of Gynecology and Obstetrics</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4860-96c916f545eae2faafcafaa1a74198e2f28e3fa9cd39b23f2d2260c76ea0a8293</citedby><cites>FETCH-LOGICAL-c4860-96c916f545eae2faafcafaa1a74198e2f28e3fa9cd39b23f2d2260c76ea0a8293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2008.01.022$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2008.01.022$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20466996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18336822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadlonova, Jana</creatorcontrib><creatorcontrib>Kostal, Milan</creatorcontrib><creatorcontrib>Smahelova, Alena</creatorcontrib><creatorcontrib>Hendl, Jan</creatorcontrib><creatorcontrib>Starkova, Jitka</creatorcontrib><creatorcontrib>Nachtigal, Petr</creatorcontrib><title>Selected metabolic parameters and the risk for uterine fibroids</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objective To analyze the possible association between insulin resistance and dyslipidemia with uterine fibroids, using objective metabolic measurements. Method A cross-sectional study of 56 women with uterine fibroids (case group) and 20 women without fibroids (control group). Levels of fasting glucose, insulin, C-peptide, sex hormone-binding globulin, and the lipid panel were measured. The short insulin tolerance test was performed. Body mass index, atherogenic index, and the indicator of insulin resistance (Kitt) were also calculated. Results Women with fibroids had significantly higher levels of serum HDL-cholesterol compared with control patients (1.8 ± 0.3 vs 1.6 ± 0.5; P < 0.05). Women with fibroids aged 30–45 years had significantly lower LDL-cholesterol levels than comparative control patients (2.9 ± 0.7 vs 3.4 ± 0.9; P < 0.05). A positive correlation between volume of the largest fibroid and serum HDL-cholesterol level was found in women aged 30–45 years. There were no differences in indicators of insulin resistance between the groups. Conclusion Insulin resistance was not shown to be a risk factor for fibroids. There is a negative association between some parameters of metabolic syndrome and fibroid volume.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidemia</subject><subject>Dyslipidemias - epidemiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Leiomyoma - blood</subject><subject>Leiomyoma - epidemiology</subject><subject>Leiomyoma - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obstetrics and Gynecology</subject><subject>Risk factor</subject><subject>Tumors</subject><subject>Uterine fibroids</subject><subject>Uterine Neoplasms - blood</subject><subject>Uterine Neoplasms - epidemiology</subject><subject>Uterine Neoplasms - metabolism</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkGLFDEQhYMo7rj6BzxIX_TWbaXSk05AXGTRdWVhD6vnkElXNL09nTGZVubfm2YGBQ_iJSHF9yrJq8fYcw4NBy5fD00YvsYGAVQDvAHEB2zFVadr0Xb6IVsBINQdajxjT3IeAIB3nD9mZ1wJIRXiil3c0UhuT321pb3dxDG4ameTLSdKubJTX-2_UZVCvq98TNVcymGiyodNiqHPT9kjb8dMz077Ofvy4f3ny4_1ze3V9eW7m9q1SkKtpdNc-nW7JkvorfXOlpXbruValQoqEt5q1wu9QeGxR5TgOkkWrEItztmrY99dit9nynuzDdnRONqJ4pyN1IgcO15APIIuxZwTebNLYWvTwXAwi21mMIttZrHNADfFtiJ6ceo-b7bU_5GcfCrAyxNgs7OjT3ZyIf_mEFoptZaFk0fuZxjp8B9Xm-tPV7drKMI3RyEVE38ESia7QJOjPqQyH9PH8O8PvP1L7sYwhfLUezpQHuKcpjIew01GA-ZuScYSDFAlFFKsxS9LhLEa</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Sadlonova, Jana</creator><creator>Kostal, Milan</creator><creator>Smahelova, Alena</creator><creator>Hendl, Jan</creator><creator>Starkova, Jitka</creator><creator>Nachtigal, Petr</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Selected metabolic parameters and the risk for uterine fibroids</title><author>Sadlonova, Jana ; Kostal, Milan ; Smahelova, Alena ; Hendl, Jan ; Starkova, Jitka ; Nachtigal, Petr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4860-96c916f545eae2faafcafaa1a74198e2f28e3fa9cd39b23f2d2260c76ea0a8293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidemia</topic><topic>Dyslipidemias - epidemiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Leiomyoma - blood</topic><topic>Leiomyoma - epidemiology</topic><topic>Leiomyoma - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obstetrics and Gynecology</topic><topic>Risk factor</topic><topic>Tumors</topic><topic>Uterine fibroids</topic><topic>Uterine Neoplasms - blood</topic><topic>Uterine Neoplasms - epidemiology</topic><topic>Uterine Neoplasms - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadlonova, Jana</creatorcontrib><creatorcontrib>Kostal, Milan</creatorcontrib><creatorcontrib>Smahelova, Alena</creatorcontrib><creatorcontrib>Hendl, Jan</creatorcontrib><creatorcontrib>Starkova, Jitka</creatorcontrib><creatorcontrib>Nachtigal, Petr</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadlonova, Jana</au><au>Kostal, Milan</au><au>Smahelova, Alena</au><au>Hendl, Jan</au><au>Starkova, Jitka</au><au>Nachtigal, Petr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selected metabolic parameters and the risk for uterine fibroids</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2008-07</date><risdate>2008</risdate><volume>102</volume><issue>1</issue><spage>50</spage><epage>54</epage><pages>50-54</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Abstract Objective To analyze the possible association between insulin resistance and dyslipidemia with uterine fibroids, using objective metabolic measurements. Method A cross-sectional study of 56 women with uterine fibroids (case group) and 20 women without fibroids (control group). Levels of fasting glucose, insulin, C-peptide, sex hormone-binding globulin, and the lipid panel were measured. The short insulin tolerance test was performed. Body mass index, atherogenic index, and the indicator of insulin resistance (Kitt) were also calculated. Results Women with fibroids had significantly higher levels of serum HDL-cholesterol compared with control patients (1.8 ± 0.3 vs 1.6 ± 0.5; P < 0.05). Women with fibroids aged 30–45 years had significantly lower LDL-cholesterol levels than comparative control patients (2.9 ± 0.7 vs 3.4 ± 0.9; P < 0.05). A positive correlation between volume of the largest fibroid and serum HDL-cholesterol level was found in women aged 30–45 years. There were no differences in indicators of insulin resistance between the groups. Conclusion Insulin resistance was not shown to be a risk factor for fibroids. There is a negative association between some parameters of metabolic syndrome and fibroid volume.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18336822</pmid><doi>10.1016/j.ijgo.2008.01.022</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cholesterol, HDL - blood Cholesterol, LDL - blood Comorbidity Cross-Sectional Studies Dyslipidemia Dyslipidemias - epidemiology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Insulin resistance Insulin Resistance - physiology Leiomyoma - blood Leiomyoma - epidemiology Leiomyoma - metabolism Medical sciences Middle Aged Obstetrics and Gynecology Risk factor Tumors Uterine fibroids Uterine Neoplasms - blood Uterine Neoplasms - epidemiology Uterine Neoplasms - metabolism |
| title | Selected metabolic parameters and the risk for uterine fibroids |
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