Alpinia zerumbet Potentially Elevates High-Density Lipoprotein Cholesterol Level in Hamsters
In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector. To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2008-06, Vol.56 (12), p.4435-4443 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Lin, Li-Yun Peng, Chiung-Chi Liang, Yu-Jing Yeh, Wan-Ting Wang, Hui-Er Yu, Tung-Hsi Peng, Robert Y |
| description | In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector. To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C elevating activity. AZ seeds contain 0.51% essential oils (SO), which are comprised of monoterpenoids, oxygenated monoterpenoids, sesquiterpenoids, oxygenated sesquiterpenoids, aldehydes, acid, and esters. Gas chromatography/mass spectrometry analysis indicated that most of the monoterpenes and sesquiterpenes were recoverable in pentane eluent, whilst the oxygenated monoterpenoids and sesquiterpenoids remained in ether eluent. The high contents of rutin, quercetin, and polyphenolics in ethanolic extract of AZ seeds exhibit moderate antilipoperoxidative but potent DPPH free radical scavenging bioactivities. Conclusively, both seed powder (SP) and SO are effective hypolipidaemics with amazingly potent HDL-C elevating capabilities. On the basis of hepatoprotectivity, SP is a more feasible hypolipidemic agent as well as a promising HDL-C elevating plant medicine. |
| doi_str_mv | 10.1021/jf800195d |
| format | Article |
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To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C elevating activity. AZ seeds contain 0.51% essential oils (SO), which are comprised of monoterpenoids, oxygenated monoterpenoids, sesquiterpenoids, oxygenated sesquiterpenoids, aldehydes, acid, and esters. Gas chromatography/mass spectrometry analysis indicated that most of the monoterpenes and sesquiterpenes were recoverable in pentane eluent, whilst the oxygenated monoterpenoids and sesquiterpenoids remained in ether eluent. The high contents of rutin, quercetin, and polyphenolics in ethanolic extract of AZ seeds exhibit moderate antilipoperoxidative but potent DPPH free radical scavenging bioactivities. Conclusively, both seed powder (SP) and SO are effective hypolipidaemics with amazingly potent HDL-C elevating capabilities. On the basis of hepatoprotectivity, SP is a more feasible hypolipidemic agent as well as a promising HDL-C elevating plant medicine.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf800195d</identifier><identifier>PMID: 18522401</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>aldehydes ; Alpinia - chemistry ; Alpinia zerumbet ; Alpinia zerumbetseed essential oils ; animal models ; Animals ; antioxidant activity ; antioxidant hypolipidemics ; Aroma and flavouring agent industries ; Bioactive Constituents ; Biological and medical sciences ; blood lipids ; chemical constituents of plants ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cricetinae ; essential oils ; esters ; Fat industries ; Flavonoids - analysis ; Food industries ; Fundamental and applied biological sciences. Psychology ; hamsters ; HDL ; hepatoprotective effect ; high density lipoprotein ; lipemic effect ; Lipid Peroxidation - drug effects ; Liver - anatomy & histology ; Male ; medicinal plants ; medicinal properties ; Mesocricetus ; monoterpenoids ; Oils, Volatile - analysis ; Organ Size - drug effects ; Phenols - analysis ; Plant Extracts - pharmacology ; Polyphenols ; quercetin ; Quercetin - analysis ; rutin ; Rutin - analysis ; seeds ; sesquiterpenoids ; solvents ; Terpenes - analysis ; terpenes and sesquiterpenes</subject><ispartof>Journal of agricultural and food chemistry, 2008-06, Vol.56 (12), p.4435-4443</ispartof><rights>Copyright © 2008 American Chemical Society</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a436t-7111d245797aa4fd04383d1877e72fbd0ed1716ae6ccdb0adbfa0d3a1c8583993</citedby><cites>FETCH-LOGICAL-a436t-7111d245797aa4fd04383d1877e72fbd0ed1716ae6ccdb0adbfa0d3a1c8583993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf800195d$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf800195d$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27074,27922,27923,56736,56786</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20449079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18522401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Li-Yun</creatorcontrib><creatorcontrib>Peng, Chiung-Chi</creatorcontrib><creatorcontrib>Liang, Yu-Jing</creatorcontrib><creatorcontrib>Yeh, Wan-Ting</creatorcontrib><creatorcontrib>Wang, Hui-Er</creatorcontrib><creatorcontrib>Yu, Tung-Hsi</creatorcontrib><creatorcontrib>Peng, Robert Y</creatorcontrib><title>Alpinia zerumbet Potentially Elevates High-Density Lipoprotein Cholesterol Level in Hamsters</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector. To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C elevating activity. AZ seeds contain 0.51% essential oils (SO), which are comprised of monoterpenoids, oxygenated monoterpenoids, sesquiterpenoids, oxygenated sesquiterpenoids, aldehydes, acid, and esters. Gas chromatography/mass spectrometry analysis indicated that most of the monoterpenes and sesquiterpenes were recoverable in pentane eluent, whilst the oxygenated monoterpenoids and sesquiterpenoids remained in ether eluent. The high contents of rutin, quercetin, and polyphenolics in ethanolic extract of AZ seeds exhibit moderate antilipoperoxidative but potent DPPH free radical scavenging bioactivities. Conclusively, both seed powder (SP) and SO are effective hypolipidaemics with amazingly potent HDL-C elevating capabilities. On the basis of hepatoprotectivity, SP is a more feasible hypolipidemic agent as well as a promising HDL-C elevating plant medicine.</description><subject>aldehydes</subject><subject>Alpinia - chemistry</subject><subject>Alpinia zerumbet</subject><subject>Alpinia zerumbetseed essential oils</subject><subject>animal models</subject><subject>Animals</subject><subject>antioxidant activity</subject><subject>antioxidant hypolipidemics</subject><subject>Aroma and flavouring agent industries</subject><subject>Bioactive Constituents</subject><subject>Biological and medical sciences</subject><subject>blood lipids</subject><subject>chemical constituents of plants</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cricetinae</subject><subject>essential oils</subject><subject>esters</subject><subject>Fat industries</subject><subject>Flavonoids - analysis</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hamsters</subject><subject>HDL</subject><subject>hepatoprotective effect</subject><subject>high density lipoprotein</subject><subject>lipemic effect</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - anatomy & histology</subject><subject>Male</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mesocricetus</subject><subject>monoterpenoids</subject><subject>Oils, Volatile - analysis</subject><subject>Organ Size - drug effects</subject><subject>Phenols - analysis</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>quercetin</subject><subject>Quercetin - analysis</subject><subject>rutin</subject><subject>Rutin - analysis</subject><subject>seeds</subject><subject>sesquiterpenoids</subject><subject>solvents</subject><subject>Terpenes - analysis</subject><subject>terpenes and sesquiterpenes</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EotvCgS8AuVCJQ2DG-WPnWJbCIi2wUtsbkjWJndaLkyx2UrF8erzsantB4jSjmZ_eGz8z9gLhLQLHd-tWAmBV6EdshgWHtECUj9kM4jKVRYkn7DSENQDIQsBTdoKy4DwHnLHvF25je0vJb-OnrjZjshpG04-WnNsml87c02hCsrC3d-kH0wc7bpOl3QwbHzHbJ_O7wZkwGj-4ZGnujUvicEHdbhSesSctuWCeH-oZu_l4eT1fpMtvnz7PL5Yp5Vk5pgIRNc8LUQmivNWQZzLTKIUwgre1BqNRYEmmbBpdA-m6JdAZYSMLmVVVdsbO97rxqp9TPEd1NjTGOerNMAVVVpwj59l_QQ6Slyh2im_2YOOHELxp1cbbjvxWIahd5uqYeWRfHkSnujP6gTyEHIHXB4BCQ6711Dc2HDkOeV7BX9N0z9mY3q_jnvwPVYpMFOp6daW-vo_dl1WpIPKv9nxLg6JbHzVvrng0BKhiYBV_cKYmqPUw-T5-wz-e8Af5YK10</recordid><startdate>20080625</startdate><enddate>20080625</enddate><creator>Lin, Li-Yun</creator><creator>Peng, Chiung-Chi</creator><creator>Liang, Yu-Jing</creator><creator>Yeh, Wan-Ting</creator><creator>Wang, Hui-Er</creator><creator>Yu, Tung-Hsi</creator><creator>Peng, Robert Y</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080625</creationdate><title>Alpinia zerumbet Potentially Elevates High-Density Lipoprotein Cholesterol Level in Hamsters</title><author>Lin, Li-Yun ; Peng, Chiung-Chi ; Liang, Yu-Jing ; Yeh, Wan-Ting ; Wang, Hui-Er ; Yu, Tung-Hsi ; Peng, Robert Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a436t-7111d245797aa4fd04383d1877e72fbd0ed1716ae6ccdb0adbfa0d3a1c8583993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>aldehydes</topic><topic>Alpinia - chemistry</topic><topic>Alpinia zerumbet</topic><topic>Alpinia zerumbetseed essential oils</topic><topic>animal models</topic><topic>Animals</topic><topic>antioxidant activity</topic><topic>antioxidant hypolipidemics</topic><topic>Aroma and flavouring agent industries</topic><topic>Bioactive Constituents</topic><topic>Biological and medical sciences</topic><topic>blood lipids</topic><topic>chemical constituents of plants</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cricetinae</topic><topic>essential oils</topic><topic>esters</topic><topic>Fat industries</topic><topic>Flavonoids - analysis</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hamsters</topic><topic>HDL</topic><topic>hepatoprotective effect</topic><topic>high density lipoprotein</topic><topic>lipemic effect</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - anatomy & histology</topic><topic>Male</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mesocricetus</topic><topic>monoterpenoids</topic><topic>Oils, Volatile - analysis</topic><topic>Organ Size - drug effects</topic><topic>Phenols - analysis</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyphenols</topic><topic>quercetin</topic><topic>Quercetin - analysis</topic><topic>rutin</topic><topic>Rutin - analysis</topic><topic>seeds</topic><topic>sesquiterpenoids</topic><topic>solvents</topic><topic>Terpenes - analysis</topic><topic>terpenes and sesquiterpenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Li-Yun</creatorcontrib><creatorcontrib>Peng, Chiung-Chi</creatorcontrib><creatorcontrib>Liang, Yu-Jing</creatorcontrib><creatorcontrib>Yeh, Wan-Ting</creatorcontrib><creatorcontrib>Wang, Hui-Er</creatorcontrib><creatorcontrib>Yu, Tung-Hsi</creatorcontrib><creatorcontrib>Peng, Robert Y</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Li-Yun</au><au>Peng, Chiung-Chi</au><au>Liang, Yu-Jing</au><au>Yeh, Wan-Ting</au><au>Wang, Hui-Er</au><au>Yu, Tung-Hsi</au><au>Peng, Robert Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpinia zerumbet Potentially Elevates High-Density Lipoprotein Cholesterol Level in Hamsters</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2008-06-25</date><risdate>2008</risdate><volume>56</volume><issue>12</issue><spage>4435</spage><epage>4443</epage><pages>4435-4443</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector. To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C elevating activity. AZ seeds contain 0.51% essential oils (SO), which are comprised of monoterpenoids, oxygenated monoterpenoids, sesquiterpenoids, oxygenated sesquiterpenoids, aldehydes, acid, and esters. Gas chromatography/mass spectrometry analysis indicated that most of the monoterpenes and sesquiterpenes were recoverable in pentane eluent, whilst the oxygenated monoterpenoids and sesquiterpenoids remained in ether eluent. The high contents of rutin, quercetin, and polyphenolics in ethanolic extract of AZ seeds exhibit moderate antilipoperoxidative but potent DPPH free radical scavenging bioactivities. Conclusively, both seed powder (SP) and SO are effective hypolipidaemics with amazingly potent HDL-C elevating capabilities. On the basis of hepatoprotectivity, SP is a more feasible hypolipidemic agent as well as a promising HDL-C elevating plant medicine.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>18522401</pmid><doi>10.1021/jf800195d</doi><tpages>9</tpages></addata></record> |
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| subjects | aldehydes Alpinia - chemistry Alpinia zerumbet Alpinia zerumbetseed essential oils animal models Animals antioxidant activity antioxidant hypolipidemics Aroma and flavouring agent industries Bioactive Constituents Biological and medical sciences blood lipids chemical constituents of plants Cholesterol, HDL - blood Cholesterol, LDL - blood Cricetinae essential oils esters Fat industries Flavonoids - analysis Food industries Fundamental and applied biological sciences. Psychology hamsters HDL hepatoprotective effect high density lipoprotein lipemic effect Lipid Peroxidation - drug effects Liver - anatomy & histology Male medicinal plants medicinal properties Mesocricetus monoterpenoids Oils, Volatile - analysis Organ Size - drug effects Phenols - analysis Plant Extracts - pharmacology Polyphenols quercetin Quercetin - analysis rutin Rutin - analysis seeds sesquiterpenoids solvents Terpenes - analysis terpenes and sesquiterpenes |
| title | Alpinia zerumbet Potentially Elevates High-Density Lipoprotein Cholesterol Level in Hamsters |
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