Biotransformation of Vinclozolin in Rat Precision-Cut Liver Slices: Comparison with in Vivo Metabolic Pattern

Vinclozolin is a dicarboxymide fungicide that presents antiandrogenic properties through its two hydrolysis products M1 and M2, which bind to the androgen receptor. Because of the lack of data on the biotransformation of vinclozolin, its metabolism was investigated in vitro in precision-cut rat live...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2008-06, Vol.56 (12), p.4832-4839
Hauptverfasser:	Bursztyka, Julian, Debrauwer, Laurent, Perdu, Elisabeth, Jouanin, Isabelle, Jaeg, Jean-Philippe, Cravedi, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	androgens animal models Animals biochemical pathways Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation Carbon Radioisotopes Chromatography, High Pressure Liquid endocrine disruptor Food industries Fundamental and applied biological sciences. Psychology hormone receptors In Vitro Techniques in vitroandin vivometabolism Kinetics liver Liver - metabolism Male mass spectrometry metabolic detoxification metabolism metabolites Methods. Procedures. Technologies Oxazoles - metabolism Oxazoles - urine Rats Rats, Wistar Spectrometry, Mass, Electrospray Ionization tissue culture toxicology Toxicology in Agriculture and Food urine Vinclozolin
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