Synchronous early-stage endometrial and ovarian cancer
Abstract Objective To explore the clinicopathologic findings and oncological outcome of early-stage synchronous endometrial and ovarian malignancies. Methods A retrospective study of 93 women with synchronous stage I ovarian and stage I–II endometrial cancer treated between December 1981 and August...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2008-07, Vol.102 (1), p.34-38 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Signorelli, Mauro Fruscio, Robert Lissoni, Andrea Alberto Pirovano, Cecilia Perego, Patrizia Mangioni, Costantino |
| description | Abstract Objective To explore the clinicopathologic findings and oncological outcome of early-stage synchronous endometrial and ovarian malignancies. Methods A retrospective study of 93 women with synchronous stage I ovarian and stage I–II endometrial cancer treated between December 1981 and August 2005 in the gynecologic oncology department of San Gerardo Hospital, Italy. Results Fifty-one percent of the ovarian tumors were stage Ia and 71% of the endometrial cancers had minimal myometrial invasion. Endometrioid histology and grade 2 disease were prevalent in both sites. Hyperplasia and endometriosis coexisted in 71% and 22% of endometrial and ovarian cancers, respectively. The actuarial 5-year disease-free and overall survival rates were 83% and 96%, respectively. Conclusion The incidence of synchronous endometrial and ovarian cancer is not negligible, especially among young women. Synchronous cancers show very favorable pathologic features and have an excellent oncologic outcome. Adjuvant therapy should be tailored according to surgical staging and histology. |
| doi_str_mv | 10.1016/j.ijgo.2007.12.012 |
| format | Article |
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Methods A retrospective study of 93 women with synchronous stage I ovarian and stage I–II endometrial cancer treated between December 1981 and August 2005 in the gynecologic oncology department of San Gerardo Hospital, Italy. Results Fifty-one percent of the ovarian tumors were stage Ia and 71% of the endometrial cancers had minimal myometrial invasion. Endometrioid histology and grade 2 disease were prevalent in both sites. Hyperplasia and endometriosis coexisted in 71% and 22% of endometrial and ovarian cancers, respectively. The actuarial 5-year disease-free and overall survival rates were 83% and 96%, respectively. Conclusion The incidence of synchronous endometrial and ovarian cancer is not negligible, especially among young women. Synchronous cancers show very favorable pathologic features and have an excellent oncologic outcome. Adjuvant therapy should be tailored according to surgical staging and histology.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2007.12.012</identifier><identifier>PMID: 18342863</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adjuvant therapy ; Adult ; Biological and medical sciences ; Comorbidity ; Disease-Free Survival ; Endometrial cancer ; Endometrial Neoplasms - epidemiology ; Endometrial Neoplasms - mortality ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Neoplasm Invasiveness ; Neoplasms, Multiple Primary - epidemiology ; Neoplasms, Multiple Primary - mortality ; Neoplasms, Multiple Primary - pathology ; Obstetrics and Gynecology ; Ovarian cancer ; Ovarian Neoplasms - epidemiology ; Ovarian Neoplasms - mortality ; Retrospective Studies ; Survival Analysis ; Synchronous cancer ; Tumors</subject><ispartof>International journal of gynecology and obstetrics, 2008-07, Vol.102 (1), p.34-38</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2008 International Federation of Gynecology and Obstetrics</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5114-58149f360dae76325ef1c65beb9ea7e89130aea0fbc08b1fe92a2132a7622dc43</citedby><cites>FETCH-LOGICAL-c5114-58149f360dae76325ef1c65beb9ea7e89130aea0fbc08b1fe92a2132a7622dc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2007.12.012$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2007.12.012$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20466993$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18342863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Signorelli, Mauro</creatorcontrib><creatorcontrib>Fruscio, Robert</creatorcontrib><creatorcontrib>Lissoni, Andrea Alberto</creatorcontrib><creatorcontrib>Pirovano, Cecilia</creatorcontrib><creatorcontrib>Perego, Patrizia</creatorcontrib><creatorcontrib>Mangioni, Costantino</creatorcontrib><title>Synchronous early-stage endometrial and ovarian cancer</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objective To explore the clinicopathologic findings and oncological outcome of early-stage synchronous endometrial and ovarian malignancies. Methods A retrospective study of 93 women with synchronous stage I ovarian and stage I–II endometrial cancer treated between December 1981 and August 2005 in the gynecologic oncology department of San Gerardo Hospital, Italy. Results Fifty-one percent of the ovarian tumors were stage Ia and 71% of the endometrial cancers had minimal myometrial invasion. Endometrioid histology and grade 2 disease were prevalent in both sites. Hyperplasia and endometriosis coexisted in 71% and 22% of endometrial and ovarian cancers, respectively. The actuarial 5-year disease-free and overall survival rates were 83% and 96%, respectively. Conclusion The incidence of synchronous endometrial and ovarian cancer is not negligible, especially among young women. Synchronous cancers show very favorable pathologic features and have an excellent oncologic outcome. Adjuvant therapy should be tailored according to surgical staging and histology.</description><subject>Adjuvant therapy</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Comorbidity</subject><subject>Disease-Free Survival</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - epidemiology</subject><subject>Endometrial Neoplasms - mortality</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasms, Multiple Primary - epidemiology</subject><subject>Neoplasms, Multiple Primary - mortality</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Obstetrics and Gynecology</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - epidemiology</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Synchronous cancer</subject><subject>Tumors</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhi0EotvCC3BAe4Fbwsw4a8cSQqoqKEWVeiicLceZFIdsUuzdorw9jnZVJA6Ik334_vHM5xHiFUKJgOpdX4b-bioJQJdIJSA9ESustSlkpc1TsQIgKDQZOhGnKfUAgBrxuTjBWlZUK7kS6nYe_fc4jdM-rdnFYS7Szt3xmsd22vIuBjes3diupweX7-Pau9FzfCGedW5I_PJ4nolvnz5-vfhcXN9cXl2cXxd-g1gVmxor00kFrWOtJG24Q682DTeGnebaoATHDrrGQ91gx4YcoSSnFVHrK3km3h7q3sfp557Tzm5D8jwMbuTcsVWGCJQ2GaQD6OOUUuTO3sewdXG2CHaxZXu72LKLLYtks60cen2svm-23P6JHPVk4M0RcMm7oYt5-JAeOYJKKWMWTh24X2Hg-T-etldfLm_kMt_7Q5CzxIfA0SYfOBtuQ2S_s-0U_j3Ah7_ifghjyK3-4JlTP-3jmL_Hok05YG-XhVj2Aeq8C0qT_A2sSq14</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Signorelli, Mauro</creator><creator>Fruscio, Robert</creator><creator>Lissoni, Andrea Alberto</creator><creator>Pirovano, Cecilia</creator><creator>Perego, Patrizia</creator><creator>Mangioni, Costantino</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Synchronous early-stage endometrial and ovarian cancer</title><author>Signorelli, Mauro ; Fruscio, Robert ; Lissoni, Andrea Alberto ; Pirovano, Cecilia ; Perego, Patrizia ; Mangioni, Costantino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5114-58149f360dae76325ef1c65beb9ea7e89130aea0fbc08b1fe92a2132a7622dc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adjuvant therapy</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Comorbidity</topic><topic>Disease-Free Survival</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - epidemiology</topic><topic>Endometrial Neoplasms - mortality</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasms, Multiple Primary - epidemiology</topic><topic>Neoplasms, Multiple Primary - mortality</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Obstetrics and Gynecology</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - epidemiology</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Synchronous cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Signorelli, Mauro</creatorcontrib><creatorcontrib>Fruscio, Robert</creatorcontrib><creatorcontrib>Lissoni, Andrea Alberto</creatorcontrib><creatorcontrib>Pirovano, Cecilia</creatorcontrib><creatorcontrib>Perego, Patrizia</creatorcontrib><creatorcontrib>Mangioni, Costantino</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Signorelli, Mauro</au><au>Fruscio, Robert</au><au>Lissoni, Andrea Alberto</au><au>Pirovano, Cecilia</au><au>Perego, Patrizia</au><au>Mangioni, Costantino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synchronous early-stage endometrial and ovarian cancer</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2008-07</date><risdate>2008</risdate><volume>102</volume><issue>1</issue><spage>34</spage><epage>38</epage><pages>34-38</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Abstract Objective To explore the clinicopathologic findings and oncological outcome of early-stage synchronous endometrial and ovarian malignancies. Methods A retrospective study of 93 women with synchronous stage I ovarian and stage I–II endometrial cancer treated between December 1981 and August 2005 in the gynecologic oncology department of San Gerardo Hospital, Italy. Results Fifty-one percent of the ovarian tumors were stage Ia and 71% of the endometrial cancers had minimal myometrial invasion. Endometrioid histology and grade 2 disease were prevalent in both sites. Hyperplasia and endometriosis coexisted in 71% and 22% of endometrial and ovarian cancers, respectively. The actuarial 5-year disease-free and overall survival rates were 83% and 96%, respectively. Conclusion The incidence of synchronous endometrial and ovarian cancer is not negligible, especially among young women. Synchronous cancers show very favorable pathologic features and have an excellent oncologic outcome. Adjuvant therapy should be tailored according to surgical staging and histology.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18342863</pmid><doi>10.1016/j.ijgo.2007.12.012</doi><tpages>5</tpages></addata></record> |
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| subjects | Adjuvant therapy Adult Biological and medical sciences Comorbidity Disease-Free Survival Endometrial cancer Endometrial Neoplasms - epidemiology Endometrial Neoplasms - mortality Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Neoplasm Invasiveness Neoplasms, Multiple Primary - epidemiology Neoplasms, Multiple Primary - mortality Neoplasms, Multiple Primary - pathology Obstetrics and Gynecology Ovarian cancer Ovarian Neoplasms - epidemiology Ovarian Neoplasms - mortality Retrospective Studies Survival Analysis Synchronous cancer Tumors |
| title | Synchronous early-stage endometrial and ovarian cancer |
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