The long and short of it – polyphosphate, PPK and bacterial survival
Inorganic polyphosphate (poly P) is present in all species tested to date, from each of the three kingdoms of life. Studied mainly in prokaryotes, poly P and its associated enzymes are important in diverse basic metabolism, in at least some structural functions and, notably, in stress responses. The...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 2008-06, Vol.33 (6), p.284-290 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| creator | Brown, Michael R.W. Kornberg, Arthur |
| description | Inorganic polyphosphate (poly P) is present in all species tested to date, from each of the three kingdoms of life. Studied mainly in prokaryotes, poly P and its associated enzymes are important in diverse basic metabolism, in at least some structural functions and, notably, in stress responses. These numerous and unrelated roles for poly P are probably the consequence of its presence in life-forms from early in evolution. The genomes of many bacterial species, including pathogens, encode a homologue of a major poly P synthetic enzyme, poly P kinase 1 (PPK1). Loss of PPK1 results in reduced poly P levels, and deletion of the
ppk1 gene in pathogens also results in a loss of virulence towards protozoa and animals. Thus far, no PPK1 homologue has been identified in higher-order eukaryotes and, therefore, PPK1 exhibits potential as a novel target for chemotherapy. |
| doi_str_mv | 10.1016/j.tibs.2008.04.005 |
| format | Article |
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ppk1 gene in pathogens also results in a loss of virulence towards protozoa and animals. 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| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 2008-06, Vol.33 (6), p.284-290 |
| issn | 0968-0004 1362-4326 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Bacteria Bacteria - enzymology Bacteria - pathogenicity Bacterial Infections - drug therapy Bacterial Infections - enzymology Bacterial Infections - genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism Genome, Bacterial Humans Phosphotransferases (Phosphate Group Acceptor) - genetics Phosphotransferases (Phosphate Group Acceptor) - metabolism Polyphosphates - metabolism |
| title | The long and short of it – polyphosphate, PPK and bacterial survival |
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