Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice

It has been hypothesized that low-affinity, uncompetitive N-methyl-d-aspartate (NMDA) antagonists may have therapeutic efficacy (e.g., in epilepsy, stroke, drug dependence) without the adverse side effects associated with high-affinity ligands (e.g., dizocilpine, phencyclidine). To determine whether...

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Veröffentlicht in:	Psychopharmacologia 1999-10, Vol.146 (3), p.280-289
Hauptverfasser:	GETER-DOUGLASS, B, WITKIN, J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amantadine Animals Anticonvulsants Anticonvulsants - pharmacology Ataxia Biological and medical sciences Convulsions Convulsions & seizures Discrimination Learning - drug effects Dizocilpine Dizocilpine Maleate - analogs & derivatives Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Drug dependence Epilepsy Excitatory Amino Acid Antagonists - pharmacology Glutamate receptors Glutamatergic system (aspartate and other excitatory aminoacids) Glutamic acid receptors (ionotropic) Ibogaine - pharmacology Ligands Locomotion Locomotor activity Male Medical sciences Memantine Memantine - pharmacology Mice Motor Activity - drug effects N-Methyl-D-aspartic acid receptors Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Phencyclidine Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Seizures Side effects
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