Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis
Bronchoalveolar lavage fluids (BALF) from patients with idiopathic pulmonary fibrosis (IPF; n=36), hypersensitivity pneumonitis (HP; n=32) and sarcoidosis (n=44) were investigated for their surfactant properties and compared to healthy control subjects (n=29). The phospholipid (PL) and protein conce...
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| Veröffentlicht in: | The European respiratory journal 1999-09, Vol.14 (3), p.565-573 |
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| creator | Gunther, A Schmidt, R Nix, F Yabut-Perez, M Guth, C Rosseau, S Siebert, C Grimminger, F Morr, H Velcovsky, HG Seeger, W |
| description | Bronchoalveolar lavage fluids (BALF) from patients with idiopathic pulmonary fibrosis (IPF; n=36), hypersensitivity pneumonitis (HP; n=32) and sarcoidosis (n=44) were investigated for their surfactant properties and compared to healthy control subjects (n=29).
The phospholipid (PL) and protein concentration, the PL:protein ratio, PL subclasses, and the surfactant apoproteins (SP)A and SP‐B were quantified in BALF. Large surfactant aggregates (LSA) were measured by means of ultracentrifugation and assayed for surface activity using the pulsating bubble surfactometer.
As compared to controls, SP‐A concentrations, LSA content and PL:protein ratios were significantly decreased in all groups, whereas PL and SP‐B concentrations remained unchanged. Changes in the phospholipid profile, with reduced percentages of phosphatidylcholine (not significant) and phosphatidylglycerol and increased fractions of phosphatidylinositol and sphingomyelin (p |
| doi_str_mv | 10.1034/j.1399-3003.1999.14c14.x |
| format | Article |
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The phospholipid (PL) and protein concentration, the PL:protein ratio, PL subclasses, and the surfactant apoproteins (SP)A and SP‐B were quantified in BALF. Large surfactant aggregates (LSA) were measured by means of ultracentrifugation and assayed for surface activity using the pulsating bubble surfactometer.
As compared to controls, SP‐A concentrations, LSA content and PL:protein ratios were significantly decreased in all groups, whereas PL and SP‐B concentrations remained unchanged. Changes in the phospholipid profile, with reduced percentages of phosphatidylcholine (not significant) and phosphatidylglycerol and increased fractions of phosphatidylinositol and sphingomyelin (p<0.05), occurred more in IPF than in HP, and not in sarcoidosis. Surface activity was found to be severely impaired in IPF (minimum surface tension (γmin) ~15–20 mN·m‐1), but only modestly affected in HP and sarcoidosis (γmin ~5 mN·m‐1) compared to controls (γmin ~0 mN·m‐1). Reconstitution of pelleted surfactant material with soluble BALF proteins further increased γmin values.
In conclusion, moderate changes in biochemical and physical surfactant properties are encountered in hypersensitivity pneumonitis and sarcoidosis, but pronounced disturbances occur in idiopathic pulmonary fibrosis.
Eur Respir J 1999; 14: 565–573.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1034/j.1399-3003.1999.14c14.x</identifier><identifier>PMID: 10543276</identifier><language>eng</language><publisher>Sheffield: Eur Respiratory Soc</publisher><subject>Adolescent ; Adult ; Aged ; Alveolitis, Extrinsic Allergic - metabolism ; Alveolitis, Extrinsic Allergic - pathology ; Alveolitis, Extrinsic Allergic - physiopathology ; Apoproteins - metabolism ; Biological and medical sciences ; Biomarkers ; Bronchoalveolar lavage fluid ; Bronchoalveolar Lavage Fluid - chemistry ; Bronchoalveolar Lavage Fluid - cytology ; Chromatography, High Pressure Liquid ; Chronic Disease ; Enzyme-Linked Immunosorbent Assay ; Female ; Glycoproteins - metabolism ; Humans ; hypersensitivity pneumonitis ; idiopathic pulmonary fibrosis ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Phosphatidylcholines - metabolism ; Phosphatidylglycerols - metabolism ; Phosphatidylinositols - metabolism ; Pneumology ; Proteolipids - metabolism ; Pulmonary Fibrosis - metabolism ; Pulmonary Fibrosis - pathology ; Pulmonary Fibrosis - physiopathology ; pulmonary surfactant ; Pulmonary Surfactant-Associated Protein A ; Pulmonary Surfactant-Associated Proteins ; Pulmonary Surfactants - metabolism ; Respiratory Function Tests ; Respiratory system : syndromes and miscellaneous diseases ; sarcoidosis ; Sarcoidosis, Pulmonary - metabolism ; Sarcoidosis, Pulmonary - pathology ; Sarcoidosis, Pulmonary - physiopathology ; Sphingomyelins - metabolism</subject><ispartof>The European respiratory journal, 1999-09, Vol.14 (3), p.565-573</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5414-7f95ae80aedfac265529ada37198c6a29539111d9106402673e2fab877a692833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1399-3003.1999.14c14.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1952047$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10543276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gunther, A</creatorcontrib><creatorcontrib>Schmidt, R</creatorcontrib><creatorcontrib>Nix, F</creatorcontrib><creatorcontrib>Yabut-Perez, M</creatorcontrib><creatorcontrib>Guth, C</creatorcontrib><creatorcontrib>Rosseau, S</creatorcontrib><creatorcontrib>Siebert, C</creatorcontrib><creatorcontrib>Grimminger, F</creatorcontrib><creatorcontrib>Morr, H</creatorcontrib><creatorcontrib>Velcovsky, HG</creatorcontrib><creatorcontrib>Seeger, W</creatorcontrib><title>Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Bronchoalveolar lavage fluids (BALF) from patients with idiopathic pulmonary fibrosis (IPF; n=36), hypersensitivity pneumonitis (HP; n=32) and sarcoidosis (n=44) were investigated for their surfactant properties and compared to healthy control subjects (n=29).
The phospholipid (PL) and protein concentration, the PL:protein ratio, PL subclasses, and the surfactant apoproteins (SP)A and SP‐B were quantified in BALF. Large surfactant aggregates (LSA) were measured by means of ultracentrifugation and assayed for surface activity using the pulsating bubble surfactometer.
As compared to controls, SP‐A concentrations, LSA content and PL:protein ratios were significantly decreased in all groups, whereas PL and SP‐B concentrations remained unchanged. Changes in the phospholipid profile, with reduced percentages of phosphatidylcholine (not significant) and phosphatidylglycerol and increased fractions of phosphatidylinositol and sphingomyelin (p<0.05), occurred more in IPF than in HP, and not in sarcoidosis. Surface activity was found to be severely impaired in IPF (minimum surface tension (γmin) ~15–20 mN·m‐1), but only modestly affected in HP and sarcoidosis (γmin ~5 mN·m‐1) compared to controls (γmin ~0 mN·m‐1). Reconstitution of pelleted surfactant material with soluble BALF proteins further increased γmin values.
In conclusion, moderate changes in biochemical and physical surfactant properties are encountered in hypersensitivity pneumonitis and sarcoidosis, but pronounced disturbances occur in idiopathic pulmonary fibrosis.
Eur Respir J 1999; 14: 565–573.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alveolitis, Extrinsic Allergic - metabolism</subject><subject>Alveolitis, Extrinsic Allergic - pathology</subject><subject>Alveolitis, Extrinsic Allergic - physiopathology</subject><subject>Apoproteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Bronchoalveolar lavage fluid</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chronic Disease</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Glycoproteins - metabolism</subject><subject>Humans</subject><subject>hypersensitivity pneumonitis</subject><subject>idiopathic pulmonary fibrosis</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phosphatidylcholines - metabolism</subject><subject>Phosphatidylglycerols - metabolism</subject><subject>Phosphatidylinositols - metabolism</subject><subject>Pneumology</subject><subject>Proteolipids - metabolism</subject><subject>Pulmonary Fibrosis - metabolism</subject><subject>Pulmonary Fibrosis - pathology</subject><subject>Pulmonary Fibrosis - physiopathology</subject><subject>pulmonary surfactant</subject><subject>Pulmonary Surfactant-Associated Protein A</subject><subject>Pulmonary Surfactant-Associated Proteins</subject><subject>Pulmonary Surfactants - metabolism</subject><subject>Respiratory Function Tests</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>sarcoidosis</subject><subject>Sarcoidosis, Pulmonary - metabolism</subject><subject>Sarcoidosis, Pulmonary - pathology</subject><subject>Sarcoidosis, Pulmonary - physiopathology</subject><subject>Sphingomyelins - metabolism</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAURi0EokPhLyAvgBUJvvEj8QapGhVoVQmJx9q64zgdj_LCTmjn3-OQEe2SlWX53Md3TAgFlgPj4sMhB651xhnjOWitcxAWRH7_hGz-PTwlG6YZz0BzdUZexHhgDJTg8JycAZOCF6XakNvvc2jQTthPFHf9EDps_eRdpL6nvvbDiNPeWzrObTf0GI608bswRB_f0_1xdCG6PqaC33460rF3c6LSNVLsaxox2MHXC_2SPGuwje7V6TwnPz9d_th-yW6-fr7aXtxkVgoQWdloia5i6Oq0VaGkLDTWyEvQlVVYaMk1ANQamBKsUCV3RYO7qixR6aLi_Jy8W_uOYfg1uziZzkfr2hZ7N8zRJAoqXYoEVitoU5oYXGPG4LsU0AAzi2RzMItLs7g0i2TzV7K5T6WvTzPmXefqR4Wr1QS8OQEYLbZNwN76-MBpWTBRJuzjit351h3_e765_HYNYgtLhrdrg72_3d_54ExM39emtcC4cEgwN1JJ_gd96KeB</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>Gunther, A</creator><creator>Schmidt, R</creator><creator>Nix, F</creator><creator>Yabut-Perez, M</creator><creator>Guth, C</creator><creator>Rosseau, S</creator><creator>Siebert, C</creator><creator>Grimminger, F</creator><creator>Morr, H</creator><creator>Velcovsky, HG</creator><creator>Seeger, W</creator><general>Eur Respiratory Soc</general><general>European Respiratory Journal</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis</title><author>Gunther, A ; Schmidt, R ; Nix, F ; Yabut-Perez, M ; Guth, C ; Rosseau, S ; Siebert, C ; Grimminger, F ; Morr, H ; Velcovsky, HG ; Seeger, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5414-7f95ae80aedfac265529ada37198c6a29539111d9106402673e2fab877a692833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alveolitis, Extrinsic Allergic - metabolism</topic><topic>Alveolitis, Extrinsic Allergic - pathology</topic><topic>Alveolitis, Extrinsic Allergic - physiopathology</topic><topic>Apoproteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Bronchoalveolar lavage fluid</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Chronic Disease</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Glycoproteins - metabolism</topic><topic>Humans</topic><topic>hypersensitivity pneumonitis</topic><topic>idiopathic pulmonary fibrosis</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phosphatidylcholines - metabolism</topic><topic>Phosphatidylglycerols - metabolism</topic><topic>Phosphatidylinositols - metabolism</topic><topic>Pneumology</topic><topic>Proteolipids - metabolism</topic><topic>Pulmonary Fibrosis - metabolism</topic><topic>Pulmonary Fibrosis - pathology</topic><topic>Pulmonary Fibrosis - physiopathology</topic><topic>pulmonary surfactant</topic><topic>Pulmonary Surfactant-Associated Protein A</topic><topic>Pulmonary Surfactant-Associated Proteins</topic><topic>Pulmonary Surfactants - metabolism</topic><topic>Respiratory Function Tests</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>sarcoidosis</topic><topic>Sarcoidosis, Pulmonary - metabolism</topic><topic>Sarcoidosis, Pulmonary - pathology</topic><topic>Sarcoidosis, Pulmonary - physiopathology</topic><topic>Sphingomyelins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gunther, A</creatorcontrib><creatorcontrib>Schmidt, R</creatorcontrib><creatorcontrib>Nix, F</creatorcontrib><creatorcontrib>Yabut-Perez, M</creatorcontrib><creatorcontrib>Guth, C</creatorcontrib><creatorcontrib>Rosseau, S</creatorcontrib><creatorcontrib>Siebert, C</creatorcontrib><creatorcontrib>Grimminger, F</creatorcontrib><creatorcontrib>Morr, H</creatorcontrib><creatorcontrib>Velcovsky, HG</creatorcontrib><creatorcontrib>Seeger, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gunther, A</au><au>Schmidt, R</au><au>Nix, F</au><au>Yabut-Perez, M</au><au>Guth, C</au><au>Rosseau, S</au><au>Siebert, C</au><au>Grimminger, F</au><au>Morr, H</au><au>Velcovsky, HG</au><au>Seeger, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>1999-09</date><risdate>1999</risdate><volume>14</volume><issue>3</issue><spage>565</spage><epage>573</epage><pages>565-573</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Bronchoalveolar lavage fluids (BALF) from patients with idiopathic pulmonary fibrosis (IPF; n=36), hypersensitivity pneumonitis (HP; n=32) and sarcoidosis (n=44) were investigated for their surfactant properties and compared to healthy control subjects (n=29).
The phospholipid (PL) and protein concentration, the PL:protein ratio, PL subclasses, and the surfactant apoproteins (SP)A and SP‐B were quantified in BALF. Large surfactant aggregates (LSA) were measured by means of ultracentrifugation and assayed for surface activity using the pulsating bubble surfactometer.
As compared to controls, SP‐A concentrations, LSA content and PL:protein ratios were significantly decreased in all groups, whereas PL and SP‐B concentrations remained unchanged. Changes in the phospholipid profile, with reduced percentages of phosphatidylcholine (not significant) and phosphatidylglycerol and increased fractions of phosphatidylinositol and sphingomyelin (p<0.05), occurred more in IPF than in HP, and not in sarcoidosis. Surface activity was found to be severely impaired in IPF (minimum surface tension (γmin) ~15–20 mN·m‐1), but only modestly affected in HP and sarcoidosis (γmin ~5 mN·m‐1) compared to controls (γmin ~0 mN·m‐1). Reconstitution of pelleted surfactant material with soluble BALF proteins further increased γmin values.
In conclusion, moderate changes in biochemical and physical surfactant properties are encountered in hypersensitivity pneumonitis and sarcoidosis, but pronounced disturbances occur in idiopathic pulmonary fibrosis.
Eur Respir J 1999; 14: 565–573.</abstract><cop>Sheffield</cop><pub>Eur Respiratory Soc</pub><pmid>10543276</pmid><doi>10.1034/j.1399-3003.1999.14c14.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Alveolitis, Extrinsic Allergic - metabolism Alveolitis, Extrinsic Allergic - pathology Alveolitis, Extrinsic Allergic - physiopathology Apoproteins - metabolism Biological and medical sciences Biomarkers Bronchoalveolar lavage fluid Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Chromatography, High Pressure Liquid Chronic Disease Enzyme-Linked Immunosorbent Assay Female Glycoproteins - metabolism Humans hypersensitivity pneumonitis idiopathic pulmonary fibrosis Leukocyte Count Male Medical sciences Middle Aged Phosphatidylcholines - metabolism Phosphatidylglycerols - metabolism Phosphatidylinositols - metabolism Pneumology Proteolipids - metabolism Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Pulmonary Fibrosis - physiopathology pulmonary surfactant Pulmonary Surfactant-Associated Protein A Pulmonary Surfactant-Associated Proteins Pulmonary Surfactants - metabolism Respiratory Function Tests Respiratory system : syndromes and miscellaneous diseases sarcoidosis Sarcoidosis, Pulmonary - metabolism Sarcoidosis, Pulmonary - pathology Sarcoidosis, Pulmonary - physiopathology Sphingomyelins - metabolism |
| title | Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis |
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