Mechanisms of protein A superantigen-induced signal transduction for proliferation of mouse B cell

Apart from many of the biological properties of protein A (PA) of Staphylococcus aureus, it has been recognized recently as a B-cell superantigen. Therefore, we investigated the molecular mechanisms of PA superantigen-induced mice splenic B-cell proliferation. Treatment of resting B cells with PA-ev...

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Veröffentlicht in:	Immunology letters 1999-10, Vol.70 (1), p.43-51
Hauptverfasser:	Das, Tanya, Sa, Gaurisankar, Ray, Prasanta K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Bcl-2 Cell Cycle Cell Division Cell Membrane - metabolism Cell Nucleus - metabolism Cells, Cultured DNA-Binding Proteins - metabolism Enzyme Activation Gene Expression MAP kinase MAP Kinase Signaling System Mice Mitogen-Activated Protein Kinases - metabolism Nuclear Proteins - metabolism Phosphorylation Proliferation Protein A Protein kinase C Protein Kinase C - physiology Protein-Tyrosine Kinases - physiology Proto-Oncogene Proteins c-bcl-2 - genetics Serum Response Factor Signal Transduction Spleen - cytology Staphylococcal Protein A - immunology Superantigens - immunology Type C Phospholipases - physiology
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