The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro
to examine the effect of A.paniculata on pancreatic b-cells. sixty minutes incubation of BRIN-BD11 in Modified Kreb-Ringer Solution containing 16.7 mM glucose (KRB-3) + 0.625 - 2.5 mg/mL A.paniculata evoked 1.7 - 3.73 fold of insulin secretion compared to 16.7 mM glucose only (p = 0.003 - p < 0.0...
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| Veröffentlicht in: | Acta medica Indonesiana 2008-04, Vol.40 (2), p.63-68 |
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| creator | Wibudi, Aris Kiranadi, Bambang Manalu, Wasmen winarto, Adi Suyono, Slamet |
| description | to examine the effect of A.paniculata on pancreatic b-cells.
sixty minutes incubation of BRIN-BD11 in Modified Kreb-Ringer Solution containing 16.7 mM glucose (KRB-3) + 0.625 - 2.5 mg/mL A.paniculata evoked 1.7 - 3.73 fold of insulin secretion compared to 16.7 mM glucose only (p = 0.003 - p < 0.001).
compared to the effect of 100 mM glibenclamide, 60 minutes incubation of BRIN-BD11 in KRB-3 containing 1.25 and 2.5 mg/mL A. paniculata evoked 1.5 fold (p=0.034) and 2.3 fold (p=0.001) insulin secretion. Twenty minutes incubation of BRIN-BD11 in KRB-3 + 0.625-5 mg/mL A.paniculata, evoked 1.4 - 4.7 fold (p = 0.002 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only. Twenty minutes incubation of BRIN-BD11 in KRB-1 containing 1.11 mM glucose + 0.625 - 10 mg/mL A.paniculata, evoked 1.3 - 3.7 fold (p = 0.019 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only.
this study conclude that A.paniculata was a very strong, dose dependent insulinotropic agent, glucose dependent and independent insulin secreting agent. This study also conclude that A.paniculata affected one of the membrane receptors, mostly ATP-dependent potassium channels (K+ATP). |
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sixty minutes incubation of BRIN-BD11 in Modified Kreb-Ringer Solution containing 16.7 mM glucose (KRB-3) + 0.625 - 2.5 mg/mL A.paniculata evoked 1.7 - 3.73 fold of insulin secretion compared to 16.7 mM glucose only (p = 0.003 - p < 0.001).
compared to the effect of 100 mM glibenclamide, 60 minutes incubation of BRIN-BD11 in KRB-3 containing 1.25 and 2.5 mg/mL A. paniculata evoked 1.5 fold (p=0.034) and 2.3 fold (p=0.001) insulin secretion. Twenty minutes incubation of BRIN-BD11 in KRB-3 + 0.625-5 mg/mL A.paniculata, evoked 1.4 - 4.7 fold (p = 0.002 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only. Twenty minutes incubation of BRIN-BD11 in KRB-1 containing 1.11 mM glucose + 0.625 - 10 mg/mL A.paniculata, evoked 1.3 - 3.7 fold (p = 0.019 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only.
this study conclude that A.paniculata was a very strong, dose dependent insulinotropic agent, glucose dependent and independent insulin secreting agent. This study also conclude that A.paniculata affected one of the membrane receptors, mostly ATP-dependent potassium channels (K+ATP).</description><identifier>ISSN: 0125-9326</identifier><identifier>PMID: 18560025</identifier><language>eng</language><publisher>Indonesia</publisher><subject>Andrographis - chemistry ; Blood Glucose - drug effects ; Diabetes Mellitus, Type 2 - drug therapy ; Humans ; In Vitro Techniques ; Insulin - metabolism ; Insulin Secretion ; Insulin-Secreting Cells - drug effects ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use</subject><ispartof>Acta medica Indonesiana, 2008-04, Vol.40 (2), p.63-68</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18560025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wibudi, Aris</creatorcontrib><creatorcontrib>Kiranadi, Bambang</creatorcontrib><creatorcontrib>Manalu, Wasmen</creatorcontrib><creatorcontrib>winarto, Adi</creatorcontrib><creatorcontrib>Suyono, Slamet</creatorcontrib><title>The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro</title><title>Acta medica Indonesiana</title><addtitle>Acta Med Indones</addtitle><description>to examine the effect of A.paniculata on pancreatic b-cells.
sixty minutes incubation of BRIN-BD11 in Modified Kreb-Ringer Solution containing 16.7 mM glucose (KRB-3) + 0.625 - 2.5 mg/mL A.paniculata evoked 1.7 - 3.73 fold of insulin secretion compared to 16.7 mM glucose only (p = 0.003 - p < 0.001).
compared to the effect of 100 mM glibenclamide, 60 minutes incubation of BRIN-BD11 in KRB-3 containing 1.25 and 2.5 mg/mL A. paniculata evoked 1.5 fold (p=0.034) and 2.3 fold (p=0.001) insulin secretion. Twenty minutes incubation of BRIN-BD11 in KRB-3 + 0.625-5 mg/mL A.paniculata, evoked 1.4 - 4.7 fold (p = 0.002 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only. Twenty minutes incubation of BRIN-BD11 in KRB-1 containing 1.11 mM glucose + 0.625 - 10 mg/mL A.paniculata, evoked 1.3 - 3.7 fold (p = 0.019 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only.
this study conclude that A.paniculata was a very strong, dose dependent insulinotropic agent, glucose dependent and independent insulin secreting agent. This study also conclude that A.paniculata affected one of the membrane receptors, mostly ATP-dependent potassium channels (K+ATP).</description><subject>Andrographis - chemistry</subject><subject>Blood Glucose - drug effects</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Insulin-Secreting Cells - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><issn>0125-9326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LAzEYhHNQbKn9C5KTKHQhHya7eyxFrVDwYD0v2eTdNpJN1iQr-u_dYj3NYYaHmblAc0KZKGrO5AwtU_oghFDCeVXKKzSjlZCEMDFHh_0RcI7K2GyDVw4PTvm8wmtvYjhENRxtwoPyVo9OZYXv3lTfWhdyuF9h-D7a1uaErU-js76I4EAl6w9Y6RPv5OAvm2O4RpedcgmWZ12g96fH_WZb7F6fXzbrXTFQ9pALpcu6lEyAAaEYgCEtkzWrgNHOdCCB1fVUnHOjdUehKruWVVwISgXVpAO-QLd_3CGGzxFSbnqbNLhpFYQxNROMyqoWU_DmHBzbHkwzRNur-NP8X8N_AaFvYU4</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Wibudi, Aris</creator><creator>Kiranadi, Bambang</creator><creator>Manalu, Wasmen</creator><creator>winarto, Adi</creator><creator>Suyono, Slamet</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro</title><author>Wibudi, Aris ; Kiranadi, Bambang ; Manalu, Wasmen ; winarto, Adi ; Suyono, Slamet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-ac797625ede5a2eed0b26928e21fdfe6e29900233dccf1e87fb283551151c0fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Andrographis - chemistry</topic><topic>Blood Glucose - drug effects</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Insulin-Secreting Cells - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wibudi, Aris</creatorcontrib><creatorcontrib>Kiranadi, Bambang</creatorcontrib><creatorcontrib>Manalu, Wasmen</creatorcontrib><creatorcontrib>winarto, Adi</creatorcontrib><creatorcontrib>Suyono, Slamet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta medica Indonesiana</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wibudi, Aris</au><au>Kiranadi, Bambang</au><au>Manalu, Wasmen</au><au>winarto, Adi</au><au>Suyono, Slamet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro</atitle><jtitle>Acta medica Indonesiana</jtitle><addtitle>Acta Med Indones</addtitle><date>2008-04</date><risdate>2008</risdate><volume>40</volume><issue>2</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>0125-9326</issn><abstract>to examine the effect of A.paniculata on pancreatic b-cells.
sixty minutes incubation of BRIN-BD11 in Modified Kreb-Ringer Solution containing 16.7 mM glucose (KRB-3) + 0.625 - 2.5 mg/mL A.paniculata evoked 1.7 - 3.73 fold of insulin secretion compared to 16.7 mM glucose only (p = 0.003 - p < 0.001).
compared to the effect of 100 mM glibenclamide, 60 minutes incubation of BRIN-BD11 in KRB-3 containing 1.25 and 2.5 mg/mL A. paniculata evoked 1.5 fold (p=0.034) and 2.3 fold (p=0.001) insulin secretion. Twenty minutes incubation of BRIN-BD11 in KRB-3 + 0.625-5 mg/mL A.paniculata, evoked 1.4 - 4.7 fold (p = 0.002 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only. Twenty minutes incubation of BRIN-BD11 in KRB-1 containing 1.11 mM glucose + 0.625 - 10 mg/mL A.paniculata, evoked 1.3 - 3.7 fold (p = 0.019 - p < 0.001) of insulin secretion compared to 16.7 mM glucose only.
this study conclude that A.paniculata was a very strong, dose dependent insulinotropic agent, glucose dependent and independent insulin secreting agent. This study also conclude that A.paniculata affected one of the membrane receptors, mostly ATP-dependent potassium channels (K+ATP).</abstract><cop>Indonesia</cop><pmid>18560025</pmid><tpages>6</tpages></addata></record> |
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| subjects | Andrographis - chemistry Blood Glucose - drug effects Diabetes Mellitus, Type 2 - drug therapy Humans In Vitro Techniques Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Plant Extracts - pharmacology Plant Extracts - therapeutic use |
| title | The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro |
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