Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: Platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression

Interleukin‐1 beta (IL‐1β) is an inflammatory cytokine whose expression is elevated in brain during seizures, ischemia, and injury. Expression of IL‐1β and its receptor can also be observed in normal brain. Platelet‐activating factor (PAF) is also a dual mediator that promotes neuronal plasticity re...

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Veröffentlicht in:	Journal of neuroscience research 1999-11, Vol.58 (4), p.593-598
Hauptverfasser:	Serou, Michael J., DeCoster, Mark A., Bazan, Nicolas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azepines - pharmacology BN50730 COX-2 Cyclooxygenase 2 Enzyme Induction - drug effects Enzyme Induction - physiology Hippocampus - cytology Hippocampus - drug effects Hippocampus - enzymology IL-1β Interleukin-1 - physiology Isoenzymes - biosynthesis Mice neurons Neurons - drug effects Neurons - enzymology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II PAF Platelet Activating Factor - analogs & derivatives Platelet Activating Factor - pharmacology Platelet Aggregation Inhibitors - pharmacology Prostaglandin-Endoperoxide Synthases - biosynthesis Rats Recombinant Proteins - pharmacology seizures Thienopyridines Triazoles - pharmacology
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