Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation
Abstract Objective The aim of the present study was to test the effect of a palatal mucoadhesive tablet containing an herbal formulation on oral malodor production and volatile sulfide compound (VSC) levels, and to evaluate its antimicrobial activity. Methods A total of 56 healthy young volunteers p...
Gespeichert in:
| Veröffentlicht in: | Journal of dentistry 2008-07, Vol.36 (7), p.535-539 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 539 |
|---|---|
| container_issue | 7 |
| container_start_page | 535 |
| container_title | Journal of dentistry |
| container_volume | 36 |
| creator | Sterer, Nir Nuas, Shada Mizrahi, Boaz Goldenberg, Chen Weiss, Ervin I Domb, Abraham Davidi, Michael Perez |
| description | Abstract Objective The aim of the present study was to test the effect of a palatal mucoadhesive tablet containing an herbal formulation on oral malodor production and volatile sulfide compound (VSC) levels, and to evaluate its antimicrobial activity. Methods A total of 56 healthy young volunteers participated in experiments 1 and 2. The palatal adhesive tablets were prepared with different active ingredients (herbal formulation, zinc and chlorhexidine), or without an active ingredient as control (placebo). Measurement included odor judge scores (two judges) and VSC readings by a sulfide monitor (Halimeter® ). In experiment 3, the antimicrobial activity of the herbal formulation ingredients ( i.e. sage, Echinacea, Lavender and Mastic gum) were tested against three oral pathogens ( Streptoccocus mutans , Porphyromonas gingivalis and Candida albicans ) by the agar diffusion test. Results Application of the palatal adhesive tablets containing herbal formulation resulted in a significant reduction in both oral malodor scores ( p < 0.001) and VSC levels ( p = 0.013). Herbal formulation showed higher significance in VSC reduction ( p = 0.001), as compared to zinc and chlorhexidine ( p = 0.024 and 0.032, respectively). Sage, Lavender and Mastic gum showed antimicrobial activity against all three oral pathogens. Conclusions Results of the present study suggest that the palatal adhesive tablets containing herbal formulation may serve as an effective means of treatment for patients complaining of oral malodor. |
| doi_str_mv | 10.1016/j.jdent.2008.04.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69215613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0300571208001085</els_id><sourcerecordid>69215613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-4ef7599d22a0cca717d84055915c17df6ad4690c58e3a4651c5786b085390b5c3</originalsourceid><addsrcrecordid>eNqFkVFr1TAUx4Mo7jr9BIIUBN9aT9okTR8UxtBNGOxBB76FNDl1qWlzTdrB_fam3guDvfiUA_n9z8n5hZC3FCoKVHwcq9HivFQ1gKyAVQD0GdlR2XYlbcXP52QHDUDJW1qfkVcpjQDAoO5ekjMqmZCtoDtydxu1Lybtgw2xiGhXs7gwF_2h0MVee71s16sJ2t5jcg9YLLr3uBQmzIt2s5t_FfcY-0wNIU5rDuT4a_Ji0D7hm9N5Tu6-fvlxeV3e3F59u7y4KQ1jsJQMh5Z3na1rDcbolrZWMuC8o9zkehDaMtGB4RIbzQSnhrdS9CB500HPTXNOPhz77mP4s2Ja1OSSQe_1jGFNSnQ15YI2GXz_BBzDGuf8NkU3S7KmrM5Uc6RMDClFHNQ-uknHQ4bU5lyN6p9ztTlXwFR2nlPvTr3XfkL7mDlJzsCnI4BZxYPDqJJxOBu0LqJZlA3uPwM-P8kbn80b7X_jAdPjJirVCtT3baHt10Hm9CbrL8Vnp5c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1030082142</pqid></control><display><type>article</type><title>Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Sterer, Nir ; Nuas, Shada ; Mizrahi, Boaz ; Goldenberg, Chen ; Weiss, Ervin I ; Domb, Abraham ; Davidi, Michael Perez</creator><creatorcontrib>Sterer, Nir ; Nuas, Shada ; Mizrahi, Boaz ; Goldenberg, Chen ; Weiss, Ervin I ; Domb, Abraham ; Davidi, Michael Perez</creatorcontrib><description>Abstract Objective The aim of the present study was to test the effect of a palatal mucoadhesive tablet containing an herbal formulation on oral malodor production and volatile sulfide compound (VSC) levels, and to evaluate its antimicrobial activity. Methods A total of 56 healthy young volunteers participated in experiments 1 and 2. The palatal adhesive tablets were prepared with different active ingredients (herbal formulation, zinc and chlorhexidine), or without an active ingredient as control (placebo). Measurement included odor judge scores (two judges) and VSC readings by a sulfide monitor (Halimeter® ). In experiment 3, the antimicrobial activity of the herbal formulation ingredients ( i.e. sage, Echinacea, Lavender and Mastic gum) were tested against three oral pathogens ( Streptoccocus mutans , Porphyromonas gingivalis and Candida albicans ) by the agar diffusion test. Results Application of the palatal adhesive tablets containing herbal formulation resulted in a significant reduction in both oral malodor scores ( p < 0.001) and VSC levels ( p = 0.013). Herbal formulation showed higher significance in VSC reduction ( p = 0.001), as compared to zinc and chlorhexidine ( p = 0.024 and 0.032, respectively). Sage, Lavender and Mastic gum showed antimicrobial activity against all three oral pathogens. Conclusions Results of the present study suggest that the palatal adhesive tablets containing herbal formulation may serve as an effective means of treatment for patients complaining of oral malodor.</description><identifier>ISSN: 0300-5712</identifier><identifier>EISSN: 1879-176X</identifier><identifier>DOI: 10.1016/j.jdent.2008.04.001</identifier><identifier>PMID: 18468761</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject><![CDATA[Adult ; Anti-Infective Agents - pharmacology ; Anti-Infective Agents, Local - administration & dosage ; Anti-Infective Agents, Local - therapeutic use ; Antimicrobial agents ; Bacteria ; Candida albicans - drug effects ; Chlorhexidine - administration & dosage ; Chlorhexidine - analogs & derivatives ; Chlorhexidine - therapeutic use ; Dentistry ; Echinacea ; Experiments ; Female ; Gluconates - administration & dosage ; Gluconates - therapeutic use ; Halitosis ; Halitosis - metabolism ; Halitosis - prevention & control ; Humans ; Ingredients ; Lavandula ; Male ; Mastic Resin ; Microbiology ; Natural medicinals ; Odors ; Oral malodor treatment ; Palate ; Phytotherapy ; Pistacia ; Placebos ; Plant Preparations - administration & dosage ; Plant Preparations - pharmacology ; Plant Preparations - therapeutic use ; Porphyromonas gingivalis - drug effects ; Resins, Plant - therapeutic use ; Salvia officinalis ; Streptococcus mutans - drug effects ; Sulfide compounds ; Sulfides - analysis ; Sustained release ; Tablets ; Zinc - administration & dosage ; Zinc - therapeutic use]]></subject><ispartof>Journal of dentistry, 2008-07, Vol.36 (7), p.535-539</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-4ef7599d22a0cca717d84055915c17df6ad4690c58e3a4651c5786b085390b5c3</citedby><cites>FETCH-LOGICAL-c440t-4ef7599d22a0cca717d84055915c17df6ad4690c58e3a4651c5786b085390b5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jdent.2008.04.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18468761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sterer, Nir</creatorcontrib><creatorcontrib>Nuas, Shada</creatorcontrib><creatorcontrib>Mizrahi, Boaz</creatorcontrib><creatorcontrib>Goldenberg, Chen</creatorcontrib><creatorcontrib>Weiss, Ervin I</creatorcontrib><creatorcontrib>Domb, Abraham</creatorcontrib><creatorcontrib>Davidi, Michael Perez</creatorcontrib><title>Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation</title><title>Journal of dentistry</title><addtitle>J Dent</addtitle><description>Abstract Objective The aim of the present study was to test the effect of a palatal mucoadhesive tablet containing an herbal formulation on oral malodor production and volatile sulfide compound (VSC) levels, and to evaluate its antimicrobial activity. Methods A total of 56 healthy young volunteers participated in experiments 1 and 2. The palatal adhesive tablets were prepared with different active ingredients (herbal formulation, zinc and chlorhexidine), or without an active ingredient as control (placebo). Measurement included odor judge scores (two judges) and VSC readings by a sulfide monitor (Halimeter® ). In experiment 3, the antimicrobial activity of the herbal formulation ingredients ( i.e. sage, Echinacea, Lavender and Mastic gum) were tested against three oral pathogens ( Streptoccocus mutans , Porphyromonas gingivalis and Candida albicans ) by the agar diffusion test. Results Application of the palatal adhesive tablets containing herbal formulation resulted in a significant reduction in both oral malodor scores ( p < 0.001) and VSC levels ( p = 0.013). Herbal formulation showed higher significance in VSC reduction ( p = 0.001), as compared to zinc and chlorhexidine ( p = 0.024 and 0.032, respectively). Sage, Lavender and Mastic gum showed antimicrobial activity against all three oral pathogens. Conclusions Results of the present study suggest that the palatal adhesive tablets containing herbal formulation may serve as an effective means of treatment for patients complaining of oral malodor.</description><subject>Adult</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Anti-Infective Agents, Local - therapeutic use</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Candida albicans - drug effects</subject><subject>Chlorhexidine - administration & dosage</subject><subject>Chlorhexidine - analogs & derivatives</subject><subject>Chlorhexidine - therapeutic use</subject><subject>Dentistry</subject><subject>Echinacea</subject><subject>Experiments</subject><subject>Female</subject><subject>Gluconates - administration & dosage</subject><subject>Gluconates - therapeutic use</subject><subject>Halitosis</subject><subject>Halitosis - metabolism</subject><subject>Halitosis - prevention & control</subject><subject>Humans</subject><subject>Ingredients</subject><subject>Lavandula</subject><subject>Male</subject><subject>Mastic Resin</subject><subject>Microbiology</subject><subject>Natural medicinals</subject><subject>Odors</subject><subject>Oral malodor treatment</subject><subject>Palate</subject><subject>Phytotherapy</subject><subject>Pistacia</subject><subject>Placebos</subject><subject>Plant Preparations - administration & dosage</subject><subject>Plant Preparations - pharmacology</subject><subject>Plant Preparations - therapeutic use</subject><subject>Porphyromonas gingivalis - drug effects</subject><subject>Resins, Plant - therapeutic use</subject><subject>Salvia officinalis</subject><subject>Streptococcus mutans - drug effects</subject><subject>Sulfide compounds</subject><subject>Sulfides - analysis</subject><subject>Sustained release</subject><subject>Tablets</subject><subject>Zinc - administration & dosage</subject><subject>Zinc - therapeutic use</subject><issn>0300-5712</issn><issn>1879-176X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFr1TAUx4Mo7jr9BIIUBN9aT9okTR8UxtBNGOxBB76FNDl1qWlzTdrB_fam3guDvfiUA_n9z8n5hZC3FCoKVHwcq9HivFQ1gKyAVQD0GdlR2XYlbcXP52QHDUDJW1qfkVcpjQDAoO5ekjMqmZCtoDtydxu1Lybtgw2xiGhXs7gwF_2h0MVee71s16sJ2t5jcg9YLLr3uBQmzIt2s5t_FfcY-0wNIU5rDuT4a_Ji0D7hm9N5Tu6-fvlxeV3e3F59u7y4KQ1jsJQMh5Z3na1rDcbolrZWMuC8o9zkehDaMtGB4RIbzQSnhrdS9CB500HPTXNOPhz77mP4s2Ja1OSSQe_1jGFNSnQ15YI2GXz_BBzDGuf8NkU3S7KmrM5Uc6RMDClFHNQ-uknHQ4bU5lyN6p9ztTlXwFR2nlPvTr3XfkL7mDlJzsCnI4BZxYPDqJJxOBu0LqJZlA3uPwM-P8kbn80b7X_jAdPjJirVCtT3baHt10Hm9CbrL8Vnp5c</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Sterer, Nir</creator><creator>Nuas, Shada</creator><creator>Mizrahi, Boaz</creator><creator>Goldenberg, Chen</creator><creator>Weiss, Ervin I</creator><creator>Domb, Abraham</creator><creator>Davidi, Michael Perez</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation</title><author>Sterer, Nir ; Nuas, Shada ; Mizrahi, Boaz ; Goldenberg, Chen ; Weiss, Ervin I ; Domb, Abraham ; Davidi, Michael Perez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-4ef7599d22a0cca717d84055915c17df6ad4690c58e3a4651c5786b085390b5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Anti-Infective Agents, Local - therapeutic use</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Candida albicans - drug effects</topic><topic>Chlorhexidine - administration & dosage</topic><topic>Chlorhexidine - analogs & derivatives</topic><topic>Chlorhexidine - therapeutic use</topic><topic>Dentistry</topic><topic>Echinacea</topic><topic>Experiments</topic><topic>Female</topic><topic>Gluconates - administration & dosage</topic><topic>Gluconates - therapeutic use</topic><topic>Halitosis</topic><topic>Halitosis - metabolism</topic><topic>Halitosis - prevention & control</topic><topic>Humans</topic><topic>Ingredients</topic><topic>Lavandula</topic><topic>Male</topic><topic>Mastic Resin</topic><topic>Microbiology</topic><topic>Natural medicinals</topic><topic>Odors</topic><topic>Oral malodor treatment</topic><topic>Palate</topic><topic>Phytotherapy</topic><topic>Pistacia</topic><topic>Placebos</topic><topic>Plant Preparations - administration & dosage</topic><topic>Plant Preparations - pharmacology</topic><topic>Plant Preparations - therapeutic use</topic><topic>Porphyromonas gingivalis - drug effects</topic><topic>Resins, Plant - therapeutic use</topic><topic>Salvia officinalis</topic><topic>Streptococcus mutans - drug effects</topic><topic>Sulfide compounds</topic><topic>Sulfides - analysis</topic><topic>Sustained release</topic><topic>Tablets</topic><topic>Zinc - administration & dosage</topic><topic>Zinc - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sterer, Nir</creatorcontrib><creatorcontrib>Nuas, Shada</creatorcontrib><creatorcontrib>Mizrahi, Boaz</creatorcontrib><creatorcontrib>Goldenberg, Chen</creatorcontrib><creatorcontrib>Weiss, Ervin I</creatorcontrib><creatorcontrib>Domb, Abraham</creatorcontrib><creatorcontrib>Davidi, Michael Perez</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sterer, Nir</au><au>Nuas, Shada</au><au>Mizrahi, Boaz</au><au>Goldenberg, Chen</au><au>Weiss, Ervin I</au><au>Domb, Abraham</au><au>Davidi, Michael Perez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation</atitle><jtitle>Journal of dentistry</jtitle><addtitle>J Dent</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>36</volume><issue>7</issue><spage>535</spage><epage>539</epage><pages>535-539</pages><issn>0300-5712</issn><eissn>1879-176X</eissn><abstract>Abstract Objective The aim of the present study was to test the effect of a palatal mucoadhesive tablet containing an herbal formulation on oral malodor production and volatile sulfide compound (VSC) levels, and to evaluate its antimicrobial activity. Methods A total of 56 healthy young volunteers participated in experiments 1 and 2. The palatal adhesive tablets were prepared with different active ingredients (herbal formulation, zinc and chlorhexidine), or without an active ingredient as control (placebo). Measurement included odor judge scores (two judges) and VSC readings by a sulfide monitor (Halimeter® ). In experiment 3, the antimicrobial activity of the herbal formulation ingredients ( i.e. sage, Echinacea, Lavender and Mastic gum) were tested against three oral pathogens ( Streptoccocus mutans , Porphyromonas gingivalis and Candida albicans ) by the agar diffusion test. Results Application of the palatal adhesive tablets containing herbal formulation resulted in a significant reduction in both oral malodor scores ( p < 0.001) and VSC levels ( p = 0.013). Herbal formulation showed higher significance in VSC reduction ( p = 0.001), as compared to zinc and chlorhexidine ( p = 0.024 and 0.032, respectively). Sage, Lavender and Mastic gum showed antimicrobial activity against all three oral pathogens. Conclusions Results of the present study suggest that the palatal adhesive tablets containing herbal formulation may serve as an effective means of treatment for patients complaining of oral malodor.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18468761</pmid><doi>10.1016/j.jdent.2008.04.001</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-5712 |
| ispartof | Journal of dentistry, 2008-07, Vol.36 (7), p.535-539 |
| issn | 0300-5712 1879-176X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69215613 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Anti-Infective Agents - pharmacology Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - therapeutic use Antimicrobial agents Bacteria Candida albicans - drug effects Chlorhexidine - administration & dosage Chlorhexidine - analogs & derivatives Chlorhexidine - therapeutic use Dentistry Echinacea Experiments Female Gluconates - administration & dosage Gluconates - therapeutic use Halitosis Halitosis - metabolism Halitosis - prevention & control Humans Ingredients Lavandula Male Mastic Resin Microbiology Natural medicinals Odors Oral malodor treatment Palate Phytotherapy Pistacia Placebos Plant Preparations - administration & dosage Plant Preparations - pharmacology Plant Preparations - therapeutic use Porphyromonas gingivalis - drug effects Resins, Plant - therapeutic use Salvia officinalis Streptococcus mutans - drug effects Sulfide compounds Sulfides - analysis Sustained release Tablets Zinc - administration & dosage Zinc - therapeutic use |
| title | Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T19%3A26%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oral%20malodor%20reduction%20by%20a%20palatal%20mucoadhesive%20tablet%20containing%20herbal%20formulation&rft.jtitle=Journal%20of%20dentistry&rft.au=Sterer,%20Nir&rft.date=2008-07-01&rft.volume=36&rft.issue=7&rft.spage=535&rft.epage=539&rft.pages=535-539&rft.issn=0300-5712&rft.eissn=1879-176X&rft_id=info:doi/10.1016/j.jdent.2008.04.001&rft_dat=%3Cproquest_cross%3E69215613%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1030082142&rft_id=info:pmid/18468761&rft_els_id=1_s2_0_S0300571208001085&rfr_iscdi=true |