Age- and sex-specific promoter function of a 2-kilobase 5'-flanking sequence of the murine luteinizing hormone receptor gene in transgenic mice

A transgenic (TG) mouse model carrying a 2-kb murine LH receptor (LHR) promoter/beta-galactosidase (beta-GAL) fusion gene was created to study the regulatory function of the 5'-flanking region of the murine LHR gene. Of the five TG mouse lines produced, three displayed high beta-GAL expression...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-11, Vol.140 (11), p.5322-5329
Hauptverfasser:	Hämäläinen, T, Poutanen, M, Huhtaniemi, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals beta-Galactosidase - genetics Brain Brain - metabolism Female Fetuses Fusion protein Galactosidase Gene Expression Gene fusion Gene sequencing Granulosa Cells - metabolism Hypothalamus Leydig cells Leydig Cells - metabolism LHR gene Luteinizing hormone Male Mesencephalon Mice Mice, Transgenic Neonates Pituitary Promoter Regions, Genetic Receptors Receptors, LH - genetics Recombinant Fusion Proteins Regulatory sequences Reverse Transcriptase Polymerase Chain Reaction Sex Sex Characteristics Spermatids Spermatogonia Testes Testis - metabolism Transfection Transgenes Transgenic mice Tumor cells Tumor Cells, Cultured β-Galactosidase
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