Human bone marrow osteoprogenitors express estrogen receptor-alpha and bone morphogenetic proteins 2 and 4 mRNA during osteoblastic differentiation

Understanding the mechanisms that control the proliferation and commitment of human stem cells into cells of the osteogenic lineage for the preservation of skeletal structure is of basic importance in bone physiology. This study examines some aspects of the differentiation in vitro of human bone mar...

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Veröffentlicht in:	Journal of cellular biochemistry 1999-12, Vol.75 (3), p.382-392
Hauptverfasser:	Oreffo, Richard O.C., Kusec, Vesna, Romberg, Silke, Triffitt, James T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alkaline Phosphatase - metabolism Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 bone morphogenetic proteins Bone Morphogenetic Proteins - genetics Cell Differentiation Cells, Cultured Collagen - genetics differentiation estrogen receptor Estrogen Receptor alpha Gene Expression Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans In Situ Hybridization mesenchymal Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin - genetics osteogenesis osteoprogenitors Receptors, Estrogen - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Transforming Growth Factor beta
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