Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects

Insulin resistance is a major pathological condition associated with obesity and metabolic syndrome. Insulin resistance and the renin–angiotensin system are intimately linked. We evaluated the role of the renin–angiotensin system in the pathogenesis of insulin resistance-associated, non-alcoholic st...

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Veröffentlicht in:	European journal of pharmacology 2008-07, Vol.588 (2), p.316-324
Hauptverfasser:	Kurita, Seiichiro, Takamura, Toshinari, Ota, Tsuguhito, Matsuzawa-Nagata, Naoto, Kita, Yuki, Uno, Masafumi, Nabemoto, Satoko, Ishikura, Kazuhide, Misu, Hirofumi, Ando, Hitoshi, Zen, Yoh, Nakanuma, Yasuni, Kaneko, Shuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II type 1 receptor blocker Angiotensin II Type 1 Receptor Blockers - therapeutic use Animals Biological and medical sciences Choline Deficiency - complications Disease Models, Animal Fatty Acids - biosynthesis Fatty Liver - drug therapy Gastroenterology. Liver. Pancreas. Abdomen Imidazoles - pharmacology Imidazoles - therapeutic use Insulin Resistance Liver Cirrhosis, Experimental - prevention & control Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Methionine - deficiency NADPH oxidase Non-alcoholic steatohepatitis Other diseases. Semiology Oxidative Stress Pharmacology. Drug treatments Rats Rats, Long-Evans Renin–angiotensin system RNA, Messenger - analysis Sterol Regulatory Element Binding Protein 1 - genetics Tetrazoles - pharmacology Tetrazoles - therapeutic use Transforming Growth Factor beta - genetics Tumor Necrosis Factor-alpha - blood
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