Synthesis and characterization of water-soluble free-base, zinc and copper porphyrin–oligonucleotide conjugates

End-capped 5′-porphyrin- and 5′-metalloporphyrin–DNA conjugates have been synthesized. Spectroscopic and HPLC properties of all conjugates have been studied. Unexpected partial metallation of free-base porphyrin–DNA conjugates has been observed during the DNA cleavage and deprotection. We describe t...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-07, Vol.16 (13), p.6544-6551
Hauptverfasser:	Mammana, Angela, Asakawa, Tomohiro, Bitsch-Jensen, Klaus, Wolfe, Amanda, Chaturantabut, Saireudee, Otani, Yuko, Li, Xiaoxu, Li, Zengmin, Nakanishi, Koji, Balaz, Milan, Ellestad, George A., Berova, Nina
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrates. Nucleosides and nucleotides Chemistry Chromatography, High Pressure Liquid Copper - chemistry DNA DNA - chemistry Exact sciences and technology Magnetic Resonance Spectroscopy MALDI-TOF Metallation Metalloporphyrins - chemistry Molecular Structure Nucleosides, nucleotides and oligonucleotides Oligonucleotide Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Organic chemistry Phosphoramidite Porphyrin Preparations and properties Solubility Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry Water - chemistry Zinc - chemistry
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