Induction of Apoptosis by Coprinus disseminatus Mycelial Culture Broth Extract in Human Cervical Carcinoma Cells
Extract of Coprinus disseminatus (pers. Fr.) (C. disseminatus) culture broth (EDCB) inhibits proliferation and induces apoptosis in the human cervical carcinoma cells at 5 μg/ml. To determine whether the cell death induced by the EDCB recruits caspases or not, one of the exclusive pathways in cell d...
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| Veröffentlicht in: | Cell Structure and Function 1999, Vol.24(4), pp.209-215 |
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| container_title | Cell Structure and Function |
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| creator | Han, Bingye Toyomastu, Tetsuo Shinozawa, Takao |
| description | Extract of Coprinus disseminatus (pers. Fr.) (C. disseminatus) culture broth (EDCB) inhibits proliferation and induces apoptosis in the human cervical carcinoma cells at 5 μg/ml. To determine whether the cell death induced by the EDCB recruits caspases or not, one of the exclusive pathways in cell death, we examined caspase-3 activity in this cell death process. The activity of caspase-3 was remarkably increased when the cell was treated with EDCB, and this activity was nullified by Z-VAD-FMK, a well known caspase-3 inhibitor. From then results, we would expect the EDCB to contain substances with the ability to induce apoptosis in the human cervical carcinoma cells. The extent of the EDCB induced apoptosis is cell line-dependent. |
| doi_str_mv | 10.1247/csf.24.209 |
| format | Article |
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Fr.) (C. disseminatus) culture broth (EDCB) inhibits proliferation and induces apoptosis in the human cervical carcinoma cells at 5 μg/ml. To determine whether the cell death induced by the EDCB recruits caspases or not, one of the exclusive pathways in cell death, we examined caspase-3 activity in this cell death process. The activity of caspase-3 was remarkably increased when the cell was treated with EDCB, and this activity was nullified by Z-VAD-FMK, a well known caspase-3 inhibitor. From then results, we would expect the EDCB to contain substances with the ability to induce apoptosis in the human cervical carcinoma cells. The extent of the EDCB induced apoptosis is cell line-dependent.</description><identifier>ISSN: 0386-7196</identifier><identifier>EISSN: 1347-3700</identifier><identifier>DOI: 10.1247/csf.24.209</identifier><identifier>PMID: 10532355</identifier><language>eng</language><publisher>Japan: Japan Society for Cell Biology</publisher><subject>Amino Acid Chloromethyl Ketones - pharmacology ; Apoptosis ; Bisbenzimidazole - pharmacology ; Caspase 3 ; Caspases - metabolism ; Cell Division - drug effects ; Cell Line ; Cell Nucleus - drug effects ; Coprinus - metabolism ; Coprinus disseminatus ; Culture Media ; Cysteine Proteinase Inhibitors - pharmacology ; DNA Fragmentation - drug effects ; Dose-Response Relationship, Drug ; Enzyme Activation - drug effects ; Female ; Fluorescent Dyes - pharmacology ; HeLa Cells ; Humans ; mycelial culture broth ; Plant Extracts - pharmacology ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Cell Structure and Function, 1999, Vol.24(4), pp.209-215</ispartof><rights>1999 by Japan Society for Cell Biology</rights><rights>Copyright Japan Science and Technology Agency 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-357c8da8e3de00ddcc6459ee4611dc732242ae3c06f99feed97039e977291393</citedby><cites>FETCH-LOGICAL-c551t-357c8da8e3de00ddcc6459ee4611dc732242ae3c06f99feed97039e977291393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10532355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Bingye</creatorcontrib><creatorcontrib>Toyomastu, Tetsuo</creatorcontrib><creatorcontrib>Shinozawa, Takao</creatorcontrib><title>Induction of Apoptosis by Coprinus disseminatus Mycelial Culture Broth Extract in Human Cervical Carcinoma Cells</title><title>Cell Structure and Function</title><addtitle>Cell Struct. Funct.</addtitle><description>Extract of Coprinus disseminatus (pers. Fr.) (C. disseminatus) culture broth (EDCB) inhibits proliferation and induces apoptosis in the human cervical carcinoma cells at 5 μg/ml. To determine whether the cell death induced by the EDCB recruits caspases or not, one of the exclusive pathways in cell death, we examined caspase-3 activity in this cell death process. The activity of caspase-3 was remarkably increased when the cell was treated with EDCB, and this activity was nullified by Z-VAD-FMK, a well known caspase-3 inhibitor. From then results, we would expect the EDCB to contain substances with the ability to induce apoptosis in the human cervical carcinoma cells. The extent of the EDCB induced apoptosis is cell line-dependent.</description><subject>Amino Acid Chloromethyl Ketones - pharmacology</subject><subject>Apoptosis</subject><subject>Bisbenzimidazole - pharmacology</subject><subject>Caspase 3</subject><subject>Caspases - metabolism</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Cell Nucleus - drug effects</subject><subject>Coprinus - metabolism</subject><subject>Coprinus disseminatus</subject><subject>Culture Media</subject><subject>Cysteine Proteinase Inhibitors - pharmacology</subject><subject>DNA Fragmentation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enzyme Activation - drug effects</subject><subject>Female</subject><subject>Fluorescent Dyes - pharmacology</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>mycelial culture broth</subject><subject>Plant Extracts - pharmacology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0386-7196</issn><issn>1347-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUuLFDEUhYMoTju68QdIQHAhVJtnpbOSsRidgRE3sw-Z1C0nTVVS5jHY_94M3T5wk5Cbj3MP5yD0mpItZUJ9cHnaMrFlRD9BG8qF6rgi5CnaEL7rO0V1f4Ze5LwnhEnSq-fojBLJGZdyg9brMFZXfAw4TvhijWuJ2Wd8d8BDXJMPNePR5wyLD7a0x9eDg9nbGQ91LjUB_pRiuceXP0uyrmAf8FVdbMADpAfvHjmbnA9xsW00z_klejbZOcOr032Obj9f3g5X3c23L9fDxU3npKSl41K53Wh3wEcgZByd64XUAKKndHSKMyaYBe5IP2k9AYxaEa5BK8U05Zqfo3dH2TXFHxVyMYvPzflsA8SaTa9Zy46TBr79D9zHmkKzZmjbKKWgvWjU-yPlUsw5wWRaNotNB0OJeSzBtBIME6aV0OA3J8l6t8D4D3pMvQEfj8A-F_sd_gA2Fe9m-K0lTgfRf3_ubTIQ-C9gUZmw</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Han, Bingye</creator><creator>Toyomastu, Tetsuo</creator><creator>Shinozawa, Takao</creator><general>Japan Society for Cell Biology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Induction of Apoptosis by Coprinus disseminatus Mycelial Culture Broth Extract in Human Cervical Carcinoma Cells</title><author>Han, Bingye ; 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| ispartof | Cell Structure and Function, 1999, Vol.24(4), pp.209-215 |
| issn | 0386-7196 1347-3700 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Amino Acid Chloromethyl Ketones - pharmacology Apoptosis Bisbenzimidazole - pharmacology Caspase 3 Caspases - metabolism Cell Division - drug effects Cell Line Cell Nucleus - drug effects Coprinus - metabolism Coprinus disseminatus Culture Media Cysteine Proteinase Inhibitors - pharmacology DNA Fragmentation - drug effects Dose-Response Relationship, Drug Enzyme Activation - drug effects Female Fluorescent Dyes - pharmacology HeLa Cells Humans mycelial culture broth Plant Extracts - pharmacology Uterine Cervical Neoplasms - pathology |
| title | Induction of Apoptosis by Coprinus disseminatus Mycelial Culture Broth Extract in Human Cervical Carcinoma Cells |
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