Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on Breast Cancer Susceptibility gene-1 (BRCA1) status

It has been reported that Breast Cancer Susceptibility gene-1 & 2 (BRCA1 & 2 are potential molecular targets for chemoprevention by isoflavone genistein (4′ 5, 7-trihydroxy isoflavone), in breast and prostate cancer cells. It is also known that BRCA1 has inhibitory activity on estrogen recep...

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Veröffentlicht in:	European journal of pharmacology 2008-07, Vol.588 (2), p.158-164
Hauptverfasser:	Thasni, Karedath Abdul Aziz, Rojini, Gopakumaran, Rakesh, S. Nair, Ratheeshkumar, Thankappan, Babu, Mani Shankar, Srinivas, Gopala, Banerji, Asoke, Srinivas, Priya
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences BRCA1 Caspase 8 - physiology Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis DNA - metabolism Estrogen receptor Estrogen Receptor alpha - analysis Female Female genital diseases Genes, BRCA1 Genistein Genistein - pharmacology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Pharmacology. Drug treatments Response Elements Tumor Suppressor Protein p53 - analysis Tumor Suppressor Proteins - analysis Tumors Ubiquitin-Protein Ligases - analysis
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