Pax2 in development and renal disease

Pax genes are associated with a variety of developmental mutations in mouse and man that are gene dosage sensitive, or haploinsufficient. The Pax2 gene encodes a DNA binding, transcription factor whose expression is essential for the development of the renal epithelium. Both gain and loss of functio...

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Veröffentlicht in:	The International journal of developmental biology 1999, Vol.43 (5), p.463-468
Hauptverfasser:	Dressler, G R, Woolf, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Coloboma - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic and Fetal Development Gene Expression Regulation, Developmental Humans Kidney - abnormalities Kidney - embryology Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Mice Pax2 gene PAX2 Transcription Factor Syndrome Transcription Factors - genetics Transcription Factors - metabolism
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