Complement activation in coronary artery bypass grafting patients without cardiopulmonary bypass : The role of tissue injury by surgical incision
Complement activation is a trigger in inducing inflammation in patients who undergo coronary artery bypass grafting (CABG) and is usually thought to be induced by the use of cardiopulmonary bypass (CPB). In this study, we examined whether tissue injury caused by chest surgical incision per se contri...
Gespeichert in:
| Veröffentlicht in: | Chest 1999-10, Vol.116 (4), p.892-898 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 898 |
|---|---|
| container_issue | 4 |
| container_start_page | 892 |
| container_title | Chest |
| container_volume | 116 |
| creator | GU, Y. J MARIANI, M. A BOONSTRA, P. W GRANDJEAN, J. G VAN OEVEREN, W |
| description | Complement activation is a trigger in inducing inflammation in patients who undergo coronary artery bypass grafting (CABG) and is usually thought to be induced by the use of cardiopulmonary bypass (CPB). In this study, we examined whether tissue injury caused by chest surgical incision per se contributes to complement activation in CABG patients.
Prospective study.
Thorax center in university hospital.
Twenty-two patients undergoing CABG without CPB were prospectively divided into two groups: a small chest incision via an anterolateral thoracotomy representing a minimized tissue injury (lateral group, n = 8), and a conventional median sternotomy representing a large tissue injury (median group, n = 14). Biochemical markers indicating complement activation as well as systemic inflammatory response were determined before, during, and after the operation.
Plasma concentrations of complement 3a increased in both the lateral and median groups right after chest incision (p < 0.01 and p < 0.05, respectively) and by the end of operation increased only in the median group (p < 0.01). The terminal complement complex 5b-9 did not increase in the lateral group, but it did increase in the median group both after incision and by the end of the operation (p < 0.05 and p < 0.05, respectively). During surgery, complement 4a did not increase, suggesting that it is the alternative rather than the classic pathway that is involved in complement activation by tissue injury. Postoperatively, interleukin-6 production was greater in the median group (p < 0.01) than the lateral group (p < 0.05), suggesting a more pronounced inflammatory response to a larger chest incision.
Tissue injury caused by surgical incision contributes to complement activation in CABG patients who are operated on without CPB. A small anterolateral thoracotomy is associated with reduced complement activation in comparison with a median sternotomy. |
| doi_str_mv | 10.1378/chest.116.4.892 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69209775</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69209775</sourcerecordid><originalsourceid>FETCH-LOGICAL-p263t-2b5df587ea61a887da82f5e7e4264caf0c74aad26049c11367e1d81ebb9641573</originalsourceid><addsrcrecordid>eNpdkM1u1DAUhS1ERYfCmh2yEOoug6-d-IddNeKnUqVuyjq6cZwZj5I42E5RH4M3rksHIbG6svWdY9-PkHfAtiCU_mQPLuUtgNzWW234C7IBI6ASTS1ekg1jwCshDT8nr1M6snIGI1-Rc2CNAKjNhvzehWkZ3eTmTNFmf4_Zh5n6mdoQw4zxgWLMrozuYcGU6D7ikP28p0shSyrRXz4fwpqpxdj7sKzj9Jw7BT7Tu4OjMYyOhoFmn9LqSv9x_YPQtMa9tziWK-tTefsNORtwTO7taV6QH1-_3O2-Vze33653VzfVwqXIFe-afmi0cigBtVY9aj40Trmay9riwKyqEXsuWW0sgJDKQa_BdZ2RNTRKXJDL594lhp9r0dhOPlk3jji7sKa2aGNGqaaAH_4Dj2GNc_lbyxlrilHz1Pb-BK3d5Pp2iX4qEtq_pgvw8QRgKusOEZ_2_ccZqYFr8QiFWZDO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>200519697</pqid></control><display><type>article</type><title>Complement activation in coronary artery bypass grafting patients without cardiopulmonary bypass : The role of tissue injury by surgical incision</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>GU, Y. J ; MARIANI, M. A ; BOONSTRA, P. W ; GRANDJEAN, J. G ; VAN OEVEREN, W</creator><creatorcontrib>GU, Y. J ; MARIANI, M. A ; BOONSTRA, P. W ; GRANDJEAN, J. G ; VAN OEVEREN, W</creatorcontrib><description><![CDATA[Complement activation is a trigger in inducing inflammation in patients who undergo coronary artery bypass grafting (CABG) and is usually thought to be induced by the use of cardiopulmonary bypass (CPB). In this study, we examined whether tissue injury caused by chest surgical incision per se contributes to complement activation in CABG patients.
Prospective study.
Thorax center in university hospital.
Twenty-two patients undergoing CABG without CPB were prospectively divided into two groups: a small chest incision via an anterolateral thoracotomy representing a minimized tissue injury (lateral group, n = 8), and a conventional median sternotomy representing a large tissue injury (median group, n = 14). Biochemical markers indicating complement activation as well as systemic inflammatory response were determined before, during, and after the operation.
Plasma concentrations of complement 3a increased in both the lateral and median groups right after chest incision (p < 0.01 and p < 0.05, respectively) and by the end of operation increased only in the median group (p < 0.01). The terminal complement complex 5b-9 did not increase in the lateral group, but it did increase in the median group both after incision and by the end of the operation (p < 0.05 and p < 0.05, respectively). During surgery, complement 4a did not increase, suggesting that it is the alternative rather than the classic pathway that is involved in complement activation by tissue injury. Postoperatively, interleukin-6 production was greater in the median group (p < 0.01) than the lateral group (p < 0.05), suggesting a more pronounced inflammatory response to a larger chest incision.
Tissue injury caused by surgical incision contributes to complement activation in CABG patients who are operated on without CPB. A small anterolateral thoracotomy is associated with reduced complement activation in comparison with a median sternotomy.]]></description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.116.4.892</identifier><identifier>PMID: 10531149</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cardiopulmonary Bypass ; Cardiovascular disease ; Complement Activation - immunology ; Complement C3a - metabolism ; Complement C4a - metabolism ; Complement Membrane Attack Complex - metabolism ; Coronary Artery Bypass ; Coronary vessels ; Cytokines ; Female ; Heart surgery ; Hospitals, University ; Humans ; Interleukin-6 - blood ; Intraoperative Period ; Male ; Medical sciences ; Middle Aged ; Netherlands ; Ostomy ; Postoperative Complications - immunology ; Prospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Sutures ; Systemic Inflammatory Response Syndrome - immunology ; Thoracotomy</subject><ispartof>Chest, 1999-10, Vol.116 (4), p.892-898</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Oct 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1968128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10531149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GU, Y. J</creatorcontrib><creatorcontrib>MARIANI, M. A</creatorcontrib><creatorcontrib>BOONSTRA, P. W</creatorcontrib><creatorcontrib>GRANDJEAN, J. G</creatorcontrib><creatorcontrib>VAN OEVEREN, W</creatorcontrib><title>Complement activation in coronary artery bypass grafting patients without cardiopulmonary bypass : The role of tissue injury by surgical incision</title><title>Chest</title><addtitle>Chest</addtitle><description><![CDATA[Complement activation is a trigger in inducing inflammation in patients who undergo coronary artery bypass grafting (CABG) and is usually thought to be induced by the use of cardiopulmonary bypass (CPB). In this study, we examined whether tissue injury caused by chest surgical incision per se contributes to complement activation in CABG patients.
Prospective study.
Thorax center in university hospital.
Twenty-two patients undergoing CABG without CPB were prospectively divided into two groups: a small chest incision via an anterolateral thoracotomy representing a minimized tissue injury (lateral group, n = 8), and a conventional median sternotomy representing a large tissue injury (median group, n = 14). Biochemical markers indicating complement activation as well as systemic inflammatory response were determined before, during, and after the operation.
Plasma concentrations of complement 3a increased in both the lateral and median groups right after chest incision (p < 0.01 and p < 0.05, respectively) and by the end of operation increased only in the median group (p < 0.01). The terminal complement complex 5b-9 did not increase in the lateral group, but it did increase in the median group both after incision and by the end of the operation (p < 0.05 and p < 0.05, respectively). During surgery, complement 4a did not increase, suggesting that it is the alternative rather than the classic pathway that is involved in complement activation by tissue injury. Postoperatively, interleukin-6 production was greater in the median group (p < 0.01) than the lateral group (p < 0.05), suggesting a more pronounced inflammatory response to a larger chest incision.
Tissue injury caused by surgical incision contributes to complement activation in CABG patients who are operated on without CPB. A small anterolateral thoracotomy is associated with reduced complement activation in comparison with a median sternotomy.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiopulmonary Bypass</subject><subject>Cardiovascular disease</subject><subject>Complement Activation - immunology</subject><subject>Complement C3a - metabolism</subject><subject>Complement C4a - metabolism</subject><subject>Complement Membrane Attack Complex - metabolism</subject><subject>Coronary Artery Bypass</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Female</subject><subject>Heart surgery</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Intraoperative Period</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Netherlands</subject><subject>Ostomy</subject><subject>Postoperative Complications - immunology</subject><subject>Prospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Sutures</subject><subject>Systemic Inflammatory Response Syndrome - immunology</subject><subject>Thoracotomy</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkM1u1DAUhS1ERYfCmh2yEOoug6-d-IddNeKnUqVuyjq6cZwZj5I42E5RH4M3rksHIbG6svWdY9-PkHfAtiCU_mQPLuUtgNzWW234C7IBI6ASTS1ekg1jwCshDT8nr1M6snIGI1-Rc2CNAKjNhvzehWkZ3eTmTNFmf4_Zh5n6mdoQw4zxgWLMrozuYcGU6D7ikP28p0shSyrRXz4fwpqpxdj7sKzj9Jw7BT7Tu4OjMYyOhoFmn9LqSv9x_YPQtMa9tziWK-tTefsNORtwTO7taV6QH1-_3O2-Vze33653VzfVwqXIFe-afmi0cigBtVY9aj40Trmay9riwKyqEXsuWW0sgJDKQa_BdZ2RNTRKXJDL594lhp9r0dhOPlk3jji7sKa2aGNGqaaAH_4Dj2GNc_lbyxlrilHz1Pb-BK3d5Pp2iX4qEtq_pgvw8QRgKusOEZ_2_ccZqYFr8QiFWZDO</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>GU, Y. J</creator><creator>MARIANI, M. A</creator><creator>BOONSTRA, P. W</creator><creator>GRANDJEAN, J. G</creator><creator>VAN OEVEREN, W</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Complement activation in coronary artery bypass grafting patients without cardiopulmonary bypass : The role of tissue injury by surgical incision</title><author>GU, Y. J ; MARIANI, M. A ; BOONSTRA, P. W ; GRANDJEAN, J. G ; VAN OEVEREN, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p263t-2b5df587ea61a887da82f5e7e4264caf0c74aad26049c11367e1d81ebb9641573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiopulmonary Bypass</topic><topic>Cardiovascular disease</topic><topic>Complement Activation - immunology</topic><topic>Complement C3a - metabolism</topic><topic>Complement C4a - metabolism</topic><topic>Complement Membrane Attack Complex - metabolism</topic><topic>Coronary Artery Bypass</topic><topic>Coronary vessels</topic><topic>Cytokines</topic><topic>Female</topic><topic>Heart surgery</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Intraoperative Period</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Netherlands</topic><topic>Ostomy</topic><topic>Postoperative Complications - immunology</topic><topic>Prospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Sutures</topic><topic>Systemic Inflammatory Response Syndrome - immunology</topic><topic>Thoracotomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GU, Y. J</creatorcontrib><creatorcontrib>MARIANI, M. A</creatorcontrib><creatorcontrib>BOONSTRA, P. W</creatorcontrib><creatorcontrib>GRANDJEAN, J. G</creatorcontrib><creatorcontrib>VAN OEVEREN, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GU, Y. J</au><au>MARIANI, M. A</au><au>BOONSTRA, P. W</au><au>GRANDJEAN, J. G</au><au>VAN OEVEREN, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complement activation in coronary artery bypass grafting patients without cardiopulmonary bypass : The role of tissue injury by surgical incision</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>116</volume><issue>4</issue><spage>892</spage><epage>898</epage><pages>892-898</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract><![CDATA[Complement activation is a trigger in inducing inflammation in patients who undergo coronary artery bypass grafting (CABG) and is usually thought to be induced by the use of cardiopulmonary bypass (CPB). In this study, we examined whether tissue injury caused by chest surgical incision per se contributes to complement activation in CABG patients.
Prospective study.
Thorax center in university hospital.
Twenty-two patients undergoing CABG without CPB were prospectively divided into two groups: a small chest incision via an anterolateral thoracotomy representing a minimized tissue injury (lateral group, n = 8), and a conventional median sternotomy representing a large tissue injury (median group, n = 14). Biochemical markers indicating complement activation as well as systemic inflammatory response were determined before, during, and after the operation.
Plasma concentrations of complement 3a increased in both the lateral and median groups right after chest incision (p < 0.01 and p < 0.05, respectively) and by the end of operation increased only in the median group (p < 0.01). The terminal complement complex 5b-9 did not increase in the lateral group, but it did increase in the median group both after incision and by the end of the operation (p < 0.05 and p < 0.05, respectively). During surgery, complement 4a did not increase, suggesting that it is the alternative rather than the classic pathway that is involved in complement activation by tissue injury. Postoperatively, interleukin-6 production was greater in the median group (p < 0.01) than the lateral group (p < 0.05), suggesting a more pronounced inflammatory response to a larger chest incision.
Tissue injury caused by surgical incision contributes to complement activation in CABG patients who are operated on without CPB. A small anterolateral thoracotomy is associated with reduced complement activation in comparison with a median sternotomy.]]></abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>10531149</pmid><doi>10.1378/chest.116.4.892</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1999-10, Vol.116 (4), p.892-898 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69209775 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Cardiopulmonary Bypass Cardiovascular disease Complement Activation - immunology Complement C3a - metabolism Complement C4a - metabolism Complement Membrane Attack Complex - metabolism Coronary Artery Bypass Coronary vessels Cytokines Female Heart surgery Hospitals, University Humans Interleukin-6 - blood Intraoperative Period Male Medical sciences Middle Aged Netherlands Ostomy Postoperative Complications - immunology Prospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Sutures Systemic Inflammatory Response Syndrome - immunology Thoracotomy |
| title | Complement activation in coronary artery bypass grafting patients without cardiopulmonary bypass : The role of tissue injury by surgical incision |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T11%3A59%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Complement%20activation%20in%20coronary%20artery%20bypass%20grafting%20patients%20without%20cardiopulmonary%20bypass%20:%20The%20role%20of%20tissue%20injury%20by%20surgical%20incision&rft.jtitle=Chest&rft.au=GU,%20Y.%20J&rft.date=1999-10-01&rft.volume=116&rft.issue=4&rft.spage=892&rft.epage=898&rft.pages=892-898&rft.issn=0012-3692&rft.eissn=1931-3543&rft.coden=CHETBF&rft_id=info:doi/10.1378/chest.116.4.892&rft_dat=%3Cproquest_pubme%3E69209775%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=200519697&rft_id=info:pmid/10531149&rfr_iscdi=true |