A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS)

Free fatty acids (FFAs) are believed to be a stimulus to elicit beta cell dysfunction. The present study was undertaken to determine whether endoplasmic reticulum (ER) stress was involved in palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS) and whether reduction of ER stres...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2008-07, Vol.475 (2), p.109-114
Hauptverfasser:	Choi, Sung-E, Lee, Youn-Jung, Jang, Hyun-Ju, Lee, Kwan-Woo, Kim, Young-Soo, Jun, Hee-Sook, Kang, Sang Sun, Chun, Jaesun, Kang, Yup
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Butylamines - pharmacology Cell Survival - drug effects Cells, Cultured Chemical chaperone Dose-Response Relationship, Drug Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - physiology ER stress Free fatty acid Glucose - pharmacology GSIS Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulinoma - pathology Molecular Chaperones - pharmacology Oxidative Stress - drug effects Palmitate Palmitic Acid - pharmacology Rats
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