Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy

Alterations of the Akt/mTOR pathway have been observed in numerous types of cancer, thus this pathway represents an exciting new target for molecular therapeutics. We investigated the expression of activated Akt (p‐Akt) and mTOR (p‐mTOR) in patients with adenocarcinoma of the cervix and the involvem...

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Veröffentlicht in:	Molecular carcinogenesis 2008-06, Vol.47 (6), p.446-457
Hauptverfasser:	Faried, Leri S., Faried, Ahmad, Kanuma, Tatsuya, Aoki, Hiroshi, Sano, Takaaki, Nakazato, Tomoko, Tamura, Tomohiro, Kuwano, Hiroyuki, Minegishi, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism adenocarcinoma of the cervix Adult Aged Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Cell Line, Tumor cisplatin Drug Screening Assays, Antitumor Female Humans Immunohistochemistry Middle Aged p-Akt p-mTOR Prognosis Protein Kinases - genetics Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism TOR Serine-Threonine Kinases Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism
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