Post‐insult minocycline treatment attenuates hypoxia‐ischemia‐induced neuroinflammation and white matter injury in the neonatal rat: a comparison of two different dose regimens

An increase in the number of activated microglia in the brain is a key feature of neuroinflammation after a hypoxic–ischemic insult to the preterm neonate and can contribute to white matter injury in the brain. Minocycline is a potent inhibitor of microglia and may have a role as a neuroprotective a...

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Veröffentlicht in:	International journal of developmental neuroscience 2008-08, Vol.26 (5), p.477-485
Hauptverfasser:	Carty, Michelle L., Wixey, Julie A., Colditz, Paul B., Buller, Kathryn M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Brain Injuries - etiology Brain Injuries - prevention & control Disease Models, Animal Dose-Response Relationship, Drug Encephalitis - etiology Encephalitis - prevention & control Hypoxia-Ischemia, Brain - complications Hypoxia–ischemia Injections, Intraperitoneal Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Minocycline Minocycline - administration & dosage Minocycline - pharmacology Minocycline - therapeutic use Myelin Sheath - metabolism Neonate Nerve Tissue - drug effects Nerve Tissue - metabolism Nerve Tissue - pathology Neuroprotective Agents - administration & dosage Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oligodendroglia - drug effects Oligodendroglia - metabolism Oligodendroglia - pathology Preterm Rats Rats, Sprague-Dawley Stem Cells - drug effects Stem Cells - metabolism Stem Cells - pathology Time Factors
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