Peripheral blood mononuclear cell production of interleukin-8 and IL-8-dependent neutrophil function in hypercholesterolemic patients

Interleukin-8 is a cytokine produced by mononuclear cells that is involved in polymorphonuclear neutrophil leukocyte (PMN) recruitment and activation. Several studies have previously demonstrated a leukocyte activation during hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) r...

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Veröffentlicht in:	Atherosclerosis 1999-10, Vol.146 (2), p.345-350
Hauptverfasser:	Porreca, Ettore, Sergi, Rita, Baccante, Giovanna, Reale, Marcella, Orsini, Luciano, Di Febbo, Concetta, Caselli, Gianfranco, Cuccurullo, Franco, Bertini, Riccardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blotting, Northern Cells, Cultured Cholesterol - blood Female Gene Expression Humans Hypercholesterolemia Hypercholesterolemia - blood Interleukin-8 Interleukin-8 - biosynthesis Interleukin-8 - blood Interleukin-8 - genetics Leukocyte Elastase - biosynthesis Leukocyte Elastase - drug effects Leukocytes Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Medical sciences Metabolic diseases Middle Aged N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophil Activation Neutrophils - drug effects Neutrophils - metabolism Obesity RNA, Messenger - genetics
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