Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent
Drug‐eluting stents have proven superior to bare metal stents with lower restenosis rates. Local delivery of drugs from these stents is achieved in most cases with the help of biostable polymer coatings. However, since the polymer coating remains in the body well after all the drug is released, pati...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2008-06, Vol.85A (4), p.1064-1071 |
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| container_end_page | 1071 |
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| container_issue | 4 |
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| container_title | Journal of biomedical materials research. Part A |
| container_volume | 85A |
| creator | Udipi, Kishore Chen, Mingfei Cheng, Peiwen Jiang, Kevin Judd, Diane Caceres, Alejandra Melder, Robert J. Wilcox, Josiah N. |
| description | Drug‐eluting stents have proven superior to bare metal stents with lower restenosis rates. Local delivery of drugs from these stents is achieved in most cases with the help of biostable polymer coatings. However, since the polymer coating remains in the body well after all the drug is released, patients can potentially develop hypersensitivity to these polymers—leading to complications such as late‐stent thrombosis. It is therefore important that the polymers are designed to be biocompatible and well tolerated by the body. The polymer coatings are also expected to be robust and provide good control over elution of the desired drug. This paper describes the development of a unique, proprietary polymer blend system, specially designed to meet these requirements. Mutually compatible, free‐radical‐initiated elastomeric polymers were designed to provide a robust coating and offer a steady, sustained release of the highly hydrophobic drug zotarolimus over an extended period. The polymer blend system is also well tolerated by the hydrophilic environment in vivo, as demonstrated through porcine studies. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008 |
| doi_str_mv | 10.1002/jbm.a.31664 |
| format | Article |
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Local delivery of drugs from these stents is achieved in most cases with the help of biostable polymer coatings. However, since the polymer coating remains in the body well after all the drug is released, patients can potentially develop hypersensitivity to these polymers—leading to complications such as late‐stent thrombosis. It is therefore important that the polymers are designed to be biocompatible and well tolerated by the body. The polymer coatings are also expected to be robust and provide good control over elution of the desired drug. This paper describes the development of a unique, proprietary polymer blend system, specially designed to meet these requirements. Mutually compatible, free‐radical‐initiated elastomeric polymers were designed to provide a robust coating and offer a steady, sustained release of the highly hydrophobic drug zotarolimus over an extended period. 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J Biomed Mater Res, 2008</description><subject>Animals</subject><subject>biocompatibility</subject><subject>Biocompatible Materials - chemical synthesis</subject><subject>Biocompatible Materials - chemistry</subject><subject>controlled drug release</subject><subject>Drug Delivery Systems</subject><subject>Drug-Eluting Stents</subject><subject>durability</subject><subject>hydrophilicity</subject><subject>Materials Testing - methods</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Sirolimus - administration & dosage</subject><subject>Sirolimus - analogs & derivatives</subject><subject>Sirolimus - chemistry</subject><subject>Spectrum Analysis, Raman</subject><subject>Swine</subject><subject>Transition Temperature</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtTxCAURhlHx3dl71DZOFkDBJKUPtfHrjbOWDIkudmJEoiQqPvvZd1VO4UCBs53iu8idEDiEYljevJctCM1YkSIZA1tE85plOSCry_uSR4xmosttOP9c4BFzOkm2iJpztKEiG00XMAbaNu1YHpsa6ywseEBF40tbdupvik04M7qeQsO-7nvocW1dRg-ejAVVLhywww70KA84MYsDOEvmoEBF-LWfBER6KFvzAwHgen30EattIf91bmLHq8uH8-vo8nD-Ob8dBKVCaVJxGqAUtQVVSUpVMkViAqyWCSLrdJcVGHlAjKuMqgzIhiJS1CZKoBz4GwXHS21nbOvA_heto0vQWtlwA5eipzGLDTxL8hoRlKekwAeL8HSWe8d1LJzTavcXJJYLqYhwzSkkl_TCPThSjsULVS_7Kr-AJAl8N5omP_lkrdn029ptMw0ocqPn4xyL1KkLOXy6X4sx_fZeDold3LCPgH-taeJ</recordid><startdate>20080615</startdate><enddate>20080615</enddate><creator>Udipi, Kishore</creator><creator>Chen, Mingfei</creator><creator>Cheng, Peiwen</creator><creator>Jiang, Kevin</creator><creator>Judd, Diane</creator><creator>Caceres, Alejandra</creator><creator>Melder, Robert J.</creator><creator>Wilcox, Josiah N.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20080615</creationdate><title>Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent</title><author>Udipi, Kishore ; Chen, Mingfei ; Cheng, Peiwen ; Jiang, Kevin ; Judd, Diane ; Caceres, Alejandra ; Melder, Robert J. ; Wilcox, Josiah N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4224-3feec6fd2ac1bac5ae6de80646464a796dddd96e85a8ef816310cea8abe55e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>biocompatibility</topic><topic>Biocompatible Materials - chemical synthesis</topic><topic>Biocompatible Materials - chemistry</topic><topic>controlled drug release</topic><topic>Drug Delivery Systems</topic><topic>Drug-Eluting Stents</topic><topic>durability</topic><topic>hydrophilicity</topic><topic>Materials Testing - methods</topic><topic>Polymers - chemical synthesis</topic><topic>Polymers - chemistry</topic><topic>Sirolimus - administration & dosage</topic><topic>Sirolimus - analogs & derivatives</topic><topic>Sirolimus - chemistry</topic><topic>Spectrum Analysis, Raman</topic><topic>Swine</topic><topic>Transition Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Udipi, Kishore</creatorcontrib><creatorcontrib>Chen, Mingfei</creatorcontrib><creatorcontrib>Cheng, Peiwen</creatorcontrib><creatorcontrib>Jiang, Kevin</creatorcontrib><creatorcontrib>Judd, Diane</creatorcontrib><creatorcontrib>Caceres, Alejandra</creatorcontrib><creatorcontrib>Melder, Robert J.</creatorcontrib><creatorcontrib>Wilcox, Josiah N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. 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Local delivery of drugs from these stents is achieved in most cases with the help of biostable polymer coatings. However, since the polymer coating remains in the body well after all the drug is released, patients can potentially develop hypersensitivity to these polymers—leading to complications such as late‐stent thrombosis. It is therefore important that the polymers are designed to be biocompatible and well tolerated by the body. The polymer coatings are also expected to be robust and provide good control over elution of the desired drug. This paper describes the development of a unique, proprietary polymer blend system, specially designed to meet these requirements. Mutually compatible, free‐radical‐initiated elastomeric polymers were designed to provide a robust coating and offer a steady, sustained release of the highly hydrophobic drug zotarolimus over an extended period. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals biocompatibility Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry controlled drug release Drug Delivery Systems Drug-Eluting Stents durability hydrophilicity Materials Testing - methods Polymers - chemical synthesis Polymers - chemistry Sirolimus - administration & dosage Sirolimus - analogs & derivatives Sirolimus - chemistry Spectrum Analysis, Raman Swine Transition Temperature |
| title | Development of a novel biocompatible polymer system for extended drug release in a next-generation drug-eluting stent |
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