Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor

A series of novel, fluorescent ligands designed to bind with high affinity and specificity to the asialoglycoprotein receptor (ASGP-R) has been synthesized and tested on human liver cells. The compounds bear three non-reducing, beta-linked Gal or GalNAc moieties linked to flexible spacers for an opt...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-05, Vol.16 (9), p.5216-5231
Hauptverfasser:	Khorev, Oleg, Stokmaier, Daniela, Schwardt, Oliver, Cutting, Brian, Ernst, Beat
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Tumor-Associated, Carbohydrate - chemistry Asialoglycoprotein Receptor - chemistry Asialoglycoprotein Receptor - drug effects Binding Sites Cell Line, Tumor Drug Design Flow Cytometry - methods Fluorescence Humans Ligands Liver - drug effects Liver - pathology Microscopy, Fluorescence - methods Molecular Structure Propylene Glycols - chemical synthesis Propylene Glycols - chemistry Propylene Glycols - pharmacology Stereoisomerism Structure-Activity Relationship
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