Synthesis and biological evaluation of thiobenzanilides as anticancer agents

Cell cycle distribution of A375 cells after treating with thiobenzanilides ( 4a– c). A series of novel thiobenzanilides is described. These compounds have been previously found to show strong biological activity such as antimycotic and antifungal actions. This is the first demonstration on the mecha...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-05, Vol.16 (9), p.5295-5302
Hauptverfasser:	Hu, Wan-Ping, Yu, Hsin-Su, Chen, Yan-Ren, Tsai, Yi-Min, Chen, Yin-Kai, Liao, Chao-Cheng, Chang, Long-Sen, Wang, Jeh-Jeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Anilides - chemical synthesis Anilides - chemistry Anilides - pharmacology Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Benzamides - chemical synthesis Benzamides - chemistry Benzamides - pharmacology Biological and medical sciences Caspase 3 - drug effects Caspase 3 - metabolism Cell Cycle - drug effects Cell Division - drug effects Cell Proliferation - drug effects DNA, Mitochondrial - chemistry DNA, Mitochondrial - drug effects Drug Screening Assays, Antitumor Flow Cytometry - methods G2 Phase - drug effects General aspects Human melanoma Humans Medical sciences Mitochondria Mitochondrial Membranes - drug effects Mitochondrial Membranes - metabolism Molecular Structure Pharmacology. Drug treatments Reactive Oxygen Species - metabolism Stereoisomerism Structure-Activity Relationship Thiobenzanilides Tumor Cells, Cultured
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