Reference intervals of serum tartrate-resistant acid phosphatase type 5b activity measured with a novel assay in Japanese subjects
Among the isotypes of serum tartrate-resistant acid phosphatase (TRACP), only type 5b (TRACP-5b) is derived from osteoclasts, and it is necessary to develop an assay specific for this TRACP-5b for evaluation of osteoclastic activity. Recently, a novel assay system for TRACP-5b called the fragments a...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2008, Vol.26 (3), p.265-270 |
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| creator | Nishizawa, Yoshiki Inaba, Masaaki Ishii, Mitsukazu Yamashita, Hiroyuki Miki, Takami Goto, Hitoshi Yamada, Sinsuke Chaki, Osamu Kurasawa, Kentaro Mochizuki, Yoshiko |
| description | Among the isotypes of serum tartrate-resistant acid phosphatase (TRACP), only type 5b (TRACP-5b) is derived from osteoclasts, and it is necessary to develop an assay specific for this TRACP-5b for evaluation of osteoclastic activity. Recently, a novel assay system for TRACP-5b called the fragments absorbed immunocapture enzymatic assay (FAICEA) has been developed. With two unique monoclonal antibodies, one that is highly specific for TRACP-5b and another which absorbs inactive TRACP-5b fragments that interfere with measuring active TRACP-5b, this assay provides correct measurement of TRACP-5b activity in the serum without interference by the inactive fragments of TRACP-5b and other isotypes of TRACP, especially TRACP-5a. To study the reference data of Japanese subjects, we measured TRACP-5b activity in the serum of 320 men (age, 20–82 years) and 466 women [315 premenopausal (age, 18–55 years) and 151 postmenopausal (age, 45–77 years)] with this novel assay. In men, serum TRACP-5b activity did not vary significantly with age. The postmenopausal women had significantly higher serum TRACP-5b activity than the premenopausal women. The reference intervals (logarithmic mean ±1.96 SD) for men, premenopausal women, and postmenopausal women were 1.7–5.9 U/l, 1.2–4.4 U/l, and 2.5–7.6 U/l, respectively. |
| doi_str_mv | 10.1007/s00774-007-0826-0 |
| format | Article |
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Recently, a novel assay system for TRACP-5b called the fragments absorbed immunocapture enzymatic assay (FAICEA) has been developed. With two unique monoclonal antibodies, one that is highly specific for TRACP-5b and another which absorbs inactive TRACP-5b fragments that interfere with measuring active TRACP-5b, this assay provides correct measurement of TRACP-5b activity in the serum without interference by the inactive fragments of TRACP-5b and other isotypes of TRACP, especially TRACP-5a. To study the reference data of Japanese subjects, we measured TRACP-5b activity in the serum of 320 men (age, 20–82 years) and 466 women [315 premenopausal (age, 18–55 years) and 151 postmenopausal (age, 45–77 years)] with this novel assay. In men, serum TRACP-5b activity did not vary significantly with age. The postmenopausal women had significantly higher serum TRACP-5b activity than the premenopausal women. The reference intervals (logarithmic mean ±1.96 SD) for men, premenopausal women, and postmenopausal women were 1.7–5.9 U/l, 1.2–4.4 U/l, and 2.5–7.6 U/l, respectively.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>18470668</pmid><doi>10.1007/s00774-007-0826-0</doi><tpages>6</tpages></addata></record> |
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| subjects | Acid Phosphatase - analysis Acid Phosphatase - blood Adolescent Adult Age Aged Aged, 80 and over Biological and medical sciences Bone Density - physiology Diseases of the osteoarticular system Female Humans Isoenzymes - analysis Isoenzymes - blood Japan Male Medical sciences Medicine Medicine & Public Health Menopause Metabolic Diseases Middle Aged Original Article Orthopedics Reference Standards Reference Values Tartrate-Resistant Acid Phosphatase Women |
| title | Reference intervals of serum tartrate-resistant acid phosphatase type 5b activity measured with a novel assay in Japanese subjects |
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