Evaluation of thermal stability of indinavir sulphate using diffuse reflectance infrared spectroscopy
Indinavir sulphate is a potent and specific protease inhibitor of human immunodeficiency virus (HIV). It is used for the treatment of acquired immune deficiency syndrome (AIDS). At elevated temperature the drug which otherwise remains crystalline undergoes a phase transition to an amorphous phase to...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2008-06, Vol.47 (2), p.248-254 |
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| container_issue | 2 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Singh, Parul Premkumar, L. Mehrotra, Ranjana Kandpal, H.C. Bakhshi, A.K. |
| description | Indinavir sulphate is a potent and specific protease inhibitor of human immunodeficiency virus (HIV). It is used for the treatment of acquired immune deficiency syndrome (AIDS). At elevated temperature the drug which otherwise remains crystalline undergoes a phase transition to an amorphous phase to form degradation products. In the present study, thermal stability of indinavir sulphate is evaluated using diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. Infrared spectra of the drug before and after the exposure to thermal radiation at different temperatures were acquired in the diffuse reflectance mode using a Fourier transform infrared (FTIR) spectrophotometer. The differential scanning calorimetry (DSC) and the X-ray diffraction (XRD) studies were used as complimentary techniques to adequately implement and assist the interpretation of the infrared spectroscopy results. The DRIFT spectra reveal that the drug remains stable up to 100
°C, degrades slightly at 125
°C and undergoes complete degradation at about 150
°C to produce degradation products. The degradation products can easily be characterized using the infrared spectra. |
| doi_str_mv | 10.1016/j.jpba.2008.01.001 |
| format | Article |
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°C, degrades slightly at 125
°C and undergoes complete degradation at about 150
°C to produce degradation products. The degradation products can easily be characterized using the infrared spectra.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2008.01.001</identifier><identifier>PMID: 18280078</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Calorimetry, Differential Scanning - methods ; Diffuse reflectance ; Drug Stability ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; HIV protease inhibitors ; HIV Protease Inhibitors - analysis ; HIV Protease Inhibitors - chemistry ; Human immunodeficiency virus ; Humans ; ICH ; Indinavir - analysis ; Indinavir - chemistry ; Indinavir sulphate ; Infrared spectroscopy ; Medical sciences ; Molecular Structure ; Pharmacology. Drug treatments ; Powder Diffraction - methods ; Spectrophotometry, Infrared - methods ; Spectroscopy, Fourier Transform Infrared ; Technology, Pharmaceutical ; Temperature ; Thermal stability</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2008-06, Vol.47 (2), p.248-254</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-b2e094ea2f06f6c9f9d49c592257eaef6938b406ef524e27b2baaac02a4d48d03</citedby><cites>FETCH-LOGICAL-c415t-b2e094ea2f06f6c9f9d49c592257eaef6938b406ef524e27b2baaac02a4d48d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpba.2008.01.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20354108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18280078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Parul</creatorcontrib><creatorcontrib>Premkumar, L.</creatorcontrib><creatorcontrib>Mehrotra, Ranjana</creatorcontrib><creatorcontrib>Kandpal, H.C.</creatorcontrib><creatorcontrib>Bakhshi, A.K.</creatorcontrib><title>Evaluation of thermal stability of indinavir sulphate using diffuse reflectance infrared spectroscopy</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>Indinavir sulphate is a potent and specific protease inhibitor of human immunodeficiency virus (HIV). It is used for the treatment of acquired immune deficiency syndrome (AIDS). At elevated temperature the drug which otherwise remains crystalline undergoes a phase transition to an amorphous phase to form degradation products. In the present study, thermal stability of indinavir sulphate is evaluated using diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. Infrared spectra of the drug before and after the exposure to thermal radiation at different temperatures were acquired in the diffuse reflectance mode using a Fourier transform infrared (FTIR) spectrophotometer. The differential scanning calorimetry (DSC) and the X-ray diffraction (XRD) studies were used as complimentary techniques to adequately implement and assist the interpretation of the infrared spectroscopy results. The DRIFT spectra reveal that the drug remains stable up to 100
°C, degrades slightly at 125
°C and undergoes complete degradation at about 150
°C to produce degradation products. The degradation products can easily be characterized using the infrared spectra.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Calorimetry, Differential Scanning - methods</subject><subject>Diffuse reflectance</subject><subject>Drug Stability</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>HIV protease inhibitors</subject><subject>HIV Protease Inhibitors - analysis</subject><subject>HIV Protease Inhibitors - chemistry</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>ICH</subject><subject>Indinavir - analysis</subject><subject>Indinavir - chemistry</subject><subject>Indinavir sulphate</subject><subject>Infrared spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>Powder Diffraction - methods</subject><subject>Spectrophotometry, Infrared - methods</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Technology, Pharmaceutical</subject><subject>Temperature</subject><subject>Thermal stability</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFq3DAQhkVpaTZpX6CH4kt7szPSyrYEvZSQNoVALg3kJsbSqNHitV3JXti3j8wu7a09DQzfDDPfz9gHDhUH3lzvqt3UYSUAVAW8AuCv2IardluKRj69Zhtot7xsQdUX7DKlHQDUXMu37IIroQBatWF0e8B-wTmMQzH6Yn6muMe-SDN2oQ_zcW2GwYUBDyEWaemnZ5ypWFIYfhUueL8kKiL5nuyMg6UM-4iRXJGm3IpjsuN0fMfeeOwTvT_XK_b47fbnzV15__D9x83X-9JKXs9lJwi0JBQeGt9Y7bWT2tZaiLolJN_oreokNORrIUm0negQ0YJA6aRysL1in097pzj-XijNZh-Spb7HgcYlmUZzrZT4PyhANKLVOoPiBNr8SsqPmimGPcaj4WDWFMzOrCmYNQUD3OQU8tDH8_al25P7O3LWnoFPZwCTxT4bG2xIf7h8YC05rNyXE0dZ2iFQNMkGyppdiNmucWP41x0vSvGn8A</recordid><startdate>20080609</startdate><enddate>20080609</enddate><creator>Singh, Parul</creator><creator>Premkumar, L.</creator><creator>Mehrotra, Ranjana</creator><creator>Kandpal, H.C.</creator><creator>Bakhshi, A.K.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080609</creationdate><title>Evaluation of thermal stability of indinavir sulphate using diffuse reflectance infrared spectroscopy</title><author>Singh, Parul ; Premkumar, L. ; Mehrotra, Ranjana ; Kandpal, H.C. ; Bakhshi, A.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-b2e094ea2f06f6c9f9d49c592257eaef6938b406ef524e27b2baaac02a4d48d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Calorimetry, Differential Scanning - methods</topic><topic>Diffuse reflectance</topic><topic>Drug Stability</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>HIV protease inhibitors</topic><topic>HIV Protease Inhibitors - analysis</topic><topic>HIV Protease Inhibitors - chemistry</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>ICH</topic><topic>Indinavir - analysis</topic><topic>Indinavir - chemistry</topic><topic>Indinavir sulphate</topic><topic>Infrared spectroscopy</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>Powder Diffraction - methods</topic><topic>Spectrophotometry, Infrared - methods</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Technology, Pharmaceutical</topic><topic>Temperature</topic><topic>Thermal stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Parul</creatorcontrib><creatorcontrib>Premkumar, L.</creatorcontrib><creatorcontrib>Mehrotra, Ranjana</creatorcontrib><creatorcontrib>Kandpal, H.C.</creatorcontrib><creatorcontrib>Bakhshi, A.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Parul</au><au>Premkumar, L.</au><au>Mehrotra, Ranjana</au><au>Kandpal, H.C.</au><au>Bakhshi, A.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of thermal stability of indinavir sulphate using diffuse reflectance infrared spectroscopy</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2008-06-09</date><risdate>2008</risdate><volume>47</volume><issue>2</issue><spage>248</spage><epage>254</epage><pages>248-254</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Indinavir sulphate is a potent and specific protease inhibitor of human immunodeficiency virus (HIV). It is used for the treatment of acquired immune deficiency syndrome (AIDS). At elevated temperature the drug which otherwise remains crystalline undergoes a phase transition to an amorphous phase to form degradation products. In the present study, thermal stability of indinavir sulphate is evaluated using diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. Infrared spectra of the drug before and after the exposure to thermal radiation at different temperatures were acquired in the diffuse reflectance mode using a Fourier transform infrared (FTIR) spectrophotometer. The differential scanning calorimetry (DSC) and the X-ray diffraction (XRD) studies were used as complimentary techniques to adequately implement and assist the interpretation of the infrared spectroscopy results. The DRIFT spectra reveal that the drug remains stable up to 100
°C, degrades slightly at 125
°C and undergoes complete degradation at about 150
°C to produce degradation products. The degradation products can easily be characterized using the infrared spectra.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18280078</pmid><doi>10.1016/j.jpba.2008.01.001</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Calorimetry, Differential Scanning - methods Diffuse reflectance Drug Stability Fundamental and applied biological sciences. Psychology General pharmacology HIV protease inhibitors HIV Protease Inhibitors - analysis HIV Protease Inhibitors - chemistry Human immunodeficiency virus Humans ICH Indinavir - analysis Indinavir - chemistry Indinavir sulphate Infrared spectroscopy Medical sciences Molecular Structure Pharmacology. Drug treatments Powder Diffraction - methods Spectrophotometry, Infrared - methods Spectroscopy, Fourier Transform Infrared Technology, Pharmaceutical Temperature Thermal stability |
| title | Evaluation of thermal stability of indinavir sulphate using diffuse reflectance infrared spectroscopy |
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