Functional-genomics-based identification of genes that regulate Arabidopsis responses to multiple abiotic stresses

Abiotic stresses are a primary cause of crop loss worldwide. The convergence of stress signalling pathways to a common set of transcription factors suggests the existence of upstream regulatory genes that control plant responses to multiple abiotic stresses. To identify such genes, data from publish...

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Veröffentlicht in:Plant, cell and environment cell and environment, 2008-06, Vol.31 (6), p.697-714
Hauptverfasser: KANT, PRAGYA, GORDON, MICHAL, KANT, SURYA, ZOLLA, GASTON, DAVYDOV, OLGA, HEIMER, YAIR M, CHALIFA-CASPI, VERED, SHAKED, RUTH, BARAK, SIMON
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container_issue 6
container_start_page 697
container_title Plant, cell and environment
container_volume 31
creator KANT, PRAGYA
GORDON, MICHAL
KANT, SURYA
ZOLLA, GASTON
DAVYDOV, OLGA
HEIMER, YAIR M
CHALIFA-CASPI, VERED
SHAKED, RUTH
BARAK, SIMON
description Abiotic stresses are a primary cause of crop loss worldwide. The convergence of stress signalling pathways to a common set of transcription factors suggests the existence of upstream regulatory genes that control plant responses to multiple abiotic stresses. To identify such genes, data from published Arabidopsis thaliana abiotic stress microarray analyses were combined with our presented global analysis of early heat stress-responsive gene expression, in a relational database. A set of Multiple Stress (MST) genes was identified by scoring each gene for the number of abiotic stresses affecting expression of that gene. ErmineJ over-representation analysis of the MST gene set identified significantly enriched gene ontology biological processes for multiple abiotic stresses and regulatory genes, particularly transcription factors. A subset of MST genes including only regulatory genes that were designated 'Multiple Stress Regulatory' (MSTR) genes, was identified. To validate this strategy for identifying MSTR genes, mutants of the highest-scoring MSTR gene encoding the circadian clock protein CCA1, were tested for altered sensitivity to stress. A double mutant of CCA1 and its structural and functional homolog, LATE ELONGLATED HYPOCOTYL, exhibited greater sensitivity to salt, osmotic and heat stress than wild-type plants. This work provides a reference data set for further study of MSTR genes.
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The convergence of stress signalling pathways to a common set of transcription factors suggests the existence of upstream regulatory genes that control plant responses to multiple abiotic stresses. To identify such genes, data from published Arabidopsis thaliana abiotic stress microarray analyses were combined with our presented global analysis of early heat stress-responsive gene expression, in a relational database. A set of Multiple Stress (MST) genes was identified by scoring each gene for the number of abiotic stresses affecting expression of that gene. ErmineJ over-representation analysis of the MST gene set identified significantly enriched gene ontology biological processes for multiple abiotic stresses and regulatory genes, particularly transcription factors. A subset of MST genes including only regulatory genes that were designated 'Multiple Stress Regulatory' (MSTR) genes, was identified. 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subjects abiotic stress responses
Arabidopsis - genetics
Arabidopsis - metabolism
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Arabidopsis thaliana
Biological and medical sciences
DNA, Plant - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Gene Expression Regulation, Plant - physiology
Genes, Plant
Genes. Genome
Genome, Plant
Genomics
heat stress transcriptome
Molecular and cellular biology
Molecular genetics
multiple stress genes
Mutation
Oligonucleotide Array Sequence Analysis
Signal Transduction - physiology
Sodium Chloride
Water
title Functional-genomics-based identification of genes that regulate Arabidopsis responses to multiple abiotic stresses
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